Breast Cancer Profiling Project, Drug Sensitivity phase I: Fixed-cell GR measures of 35 breast cell lines to 34 small molecule perturbagens from library plate I. Dataset 1 of 2: Normalized growth rate inhibition values - Dataset (ID:20343)

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Cell Small Molecule Small Mol Concentration (uM) Primary Target Pathway Mean Normalized Growth Rate Inhibition Value Increased Fraction Dead
PDXHCI002 PF-4708671
0.1
p70S6K
PI3K/mTOR
 1.0633 0.00263
PDXHCI002 PF-4708671
0.31623
p70S6K
PI3K/mTOR
 1.0853 -0.00300
PDXHCI002 PF-4708671
1.0
p70S6K
PI3K/mTOR
 1.0503 -0.00410
PDXHCI002 PF-4708671
3.1623
p70S6K
PI3K/mTOR
 0.9524 -0.00460
PDXHCI002 PF-4708671
10.0
p70S6K
PI3K/mTOR
 0.8732 -0.00956
PDXHCI002 Buparlisib
0.001
pan PI3K
PI3K/mTOR
 1.0548 -0.00299
PDXHCI002 Buparlisib
0.0031623
pan PI3K
PI3K/mTOR
 1.0571 -0.00010
PDXHCI002 Buparlisib
0.01
pan PI3K
PI3K/mTOR
 1.1174 -0.00711
PDXHCI002 Buparlisib
0.031623
pan PI3K
PI3K/mTOR
 1.0781 -0.00589
PDXHCI002 Buparlisib
0.1
pan PI3K
PI3K/mTOR
 1.0685 -0.01618
PDXHCI002 Buparlisib
0.31623
pan PI3K
PI3K/mTOR
 1.0465 -0.01370
PDXHCI002 Buparlisib
1.0
pan PI3K
PI3K/mTOR
 0.7954 0.00840
PDXHCI002 Buparlisib
3.1623
pan PI3K
PI3K/mTOR
 -0.2847 0.49269
PDXHCI002 Buparlisib
10.0
pan PI3K
PI3K/mTOR
 -0.4797 0.65015
PDXHCI002 Pictilisib
0.001
pan PI3K
PI3K/mTOR
 1.0331 0.00116
PDXHCI002 Pictilisib
0.0031623
pan PI3K
PI3K/mTOR
 1.0333 0.00338
PDXHCI002 Pictilisib
0.01
pan PI3K
PI3K/mTOR
 0.9772 -0.00348
PDXHCI002 Pictilisib
0.031623
pan PI3K
PI3K/mTOR
 0.9369 0.00124
PDXHCI002 Pictilisib
0.1
pan PI3K
PI3K/mTOR
 0.8837 -0.01119
PDXHCI002 Pictilisib
0.31623
pan PI3K
PI3K/mTOR
 0.7729 -0.01239
PDXHCI002 Pictilisib
1.0
pan PI3K
PI3K/mTOR
 0.6468 -0.01025
PDXHCI002 Pictilisib
3.1623
pan PI3K
PI3K/mTOR
 0.5400 -0.00043
PDXHCI002 Pictilisib
10.0
pan PI3K
PI3K/mTOR
 -0.0101 0.26950
PDXHCI002 Ceritinib
0.001
ALK
RTK
 1.0538 0.00190
PDXHCI002 Ceritinib
0.0031623
ALK
RTK
 1.0976 -0.00284