Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)
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| Cell | Small Molecule 1 | Small Molecule 2 | Small Mol 1 Concentration | Small Mol 2 Concentration | Small Mol Conc Unit | Time Point | Time Point Unit | Replicate | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A-375 | Vemurafenib | I-BET | 0.316 | 1.000 | uM | 72 | hr | 1 | 3202 | 283 | 0.2141 | 0.1908 | 0.0884 | 0.0841 |
| A-375 | Vemurafenib | I-BET | 0.316 | 1.000 | uM | 72 | hr | 2 | 2743 | 211 | 0.1857 | 0.1908 | 0.0769 | 0.0841 |
| A-375 | Vemurafenib | I-BET | 0.316 | 1.000 | uM | 72 | hr | 3 | 2577 | 224 | 0.1726 | 0.1908 | 0.0869 | 0.0841 |
| A-375 | Vemurafenib | I-BET | 1.000 | 0.000 | uM | 72 | hr | 1 | 2903 | 154 | 0.2016 | 0.2001 | 0.0530 | 0.0505 |
| A-375 | Vemurafenib | I-BET | 1.000 | 0.000 | uM | 72 | hr | 2 | 2825 | 122 | 0.1982 | 0.2001 | 0.0432 | 0.0505 |
| A-375 | Vemurafenib | I-BET | 1.000 | 0.000 | uM | 72 | hr | 3 | 2894 | 160 | 0.2005 | 0.2001 | 0.0553 | 0.0505 |
| A-375 | Vemurafenib | I-BET | 1.000 | 1.000 | uM | 72 | hr | 1 | 2449 | 464 | 0.1456 | 0.1297 | 0.1895 | 0.1798 |
| A-375 | Vemurafenib | I-BET | 1.000 | 1.000 | uM | 72 | hr | 2 | 2278 | 420 | 0.1363 | 0.1297 | 0.1844 | 0.1798 |
| A-375 | Vemurafenib | I-BET | 1.000 | 1.000 | uM | 72 | hr | 3 | 1752 | 290 | 0.1072 | 0.1297 | 0.1655 | 0.1798 |
| A-375 | Vemurafenib | I-BET | 3.160 | 0.000 | uM | 72 | hr | 1 | 2267 | 214 | 0.1506 | 0.1492 | 0.0944 | 0.1045 |
| A-375 | Vemurafenib | I-BET | 3.160 | 0.000 | uM | 72 | hr | 2 | 2263 | 238 | 0.1485 | 0.1492 | 0.1052 | 0.1045 |
| A-375 | Vemurafenib | I-BET | 3.160 | 0.000 | uM | 72 | hr | 3 | 2285 | 260 | 0.1485 | 0.1492 | 0.1138 | 0.1045 |
| A-375 | Vemurafenib | I-BET | 3.160 | 1.000 | uM | 72 | hr | 1 | 1996 | 611 | 0.1016 | 0.0866 | 0.3061 | 0.3091 |
| A-375 | Vemurafenib | I-BET | 3.160 | 1.000 | uM | 72 | hr | 2 | 1594 | 450 | 0.0839 | 0.0866 | 0.2823 | 0.3091 |
| A-375 | Vemurafenib | I-BET | 3.160 | 1.000 | uM | 72 | hr | 3 | 1534 | 520 | 0.0744 | 0.0866 | 0.3390 | 0.3091 |
| A-375 | Vemurafenib | I-BET151 | 0.000 | 0.000 | uM | 72 | hr | 1 | 17149 | 1786 | 1.1105 | 1.0000 | 0.1041 | 0.1052 |
| A-375 | Vemurafenib | I-BET151 | 0.000 | 0.000 | uM | 72 | hr | 2 | 15439 | 1571 | 1.0024 | 1.0000 | 0.1018 | 0.1052 |
| A-375 | Vemurafenib | I-BET151 | 0.000 | 0.000 | uM | 72 | hr | 3 | 13787 | 1514 | 0.8871 | 1.0000 | 0.1098 | 0.1052 |
| A-375 | Vemurafenib | I-BET151 | 0.000 | 1.000 | uM | 72 | hr | 1 | 8664 | 779 | 0.5699 | 0.5149 | 0.0899 | 0.0833 |
| A-375 | Vemurafenib | I-BET151 | 0.000 | 1.000 | uM | 72 | hr | 2 | 7471 | 599 | 0.4967 | 0.5149 | 0.0802 | 0.0833 |
| A-375 | Vemurafenib | I-BET151 | 0.000 | 1.000 | uM | 72 | hr | 3 | 7185 | 573 | 0.4779 | 0.5149 | 0.0797 | 0.0833 |
| A-375 | Vemurafenib | I-BET151 | 0.100 | 0.000 | uM | 72 | hr | 1 | 7410 | 177 | 0.5228 | 0.5085 | 0.0239 | 0.0264 |
| A-375 | Vemurafenib | I-BET151 | 0.100 | 0.000 | uM | 72 | hr | 2 | 7304 | 215 | 0.5124 | 0.5085 | 0.0294 | 0.0264 |
| A-375 | Vemurafenib | I-BET151 | 0.100 | 0.000 | uM | 72 | hr | 3 | 6963 | 180 | 0.4903 | 0.5085 | 0.0259 | 0.0264 |
| A-375 | Vemurafenib | I-BET151 | 0.100 | 1.000 | uM | 72 | hr | 1 | 4645 | 211 | 0.3205 | 0.2971 | 0.0454 | 0.0480 |