Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)
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| Cell | Small Molecule 1 | Small Molecule 2 | Small Mol 1 Concentration | Small Mol 2 Concentration | Small Mol Conc Unit | Time Point | Time Point Unit | Replicate | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WM-115 | Vemurafenib | I-BET | 3.160 | 0.000 | uM | 72 | hr | 2 | 2032 | 364 | 0.4785 | 0.4809 | 0.1791 | 0.1624 |
| WM-115 | Vemurafenib | I-BET | 3.160 | 0.000 | uM | 72 | hr | 3 | 1930 | 298 | 0.4682 | 0.4809 | 0.1544 | 0.1624 |
| WM-115 | Vemurafenib | I-BET | 3.160 | 1.000 | uM | 72 | hr | 1 | 1462 | 511 | 0.2728 | 0.2502 | 0.3495 | 0.3719 |
| WM-115 | Vemurafenib | I-BET | 3.160 | 1.000 | uM | 72 | hr | 2 | 1433 | 529 | 0.2593 | 0.2502 | 0.3692 | 0.3719 |
| WM-115 | Vemurafenib | I-BET | 3.160 | 1.000 | uM | 72 | hr | 3 | 1264 | 502 | 0.2186 | 0.2502 | 0.3972 | 0.3719 |
| WM-115 | Vemurafenib | I-BET151 | 0.000 | 0.000 | uM | 72 | hr | 1 | 3837 | 220 | 1.0367 | 1.0000 | 0.0573 | 0.0549 |
| WM-115 | Vemurafenib | I-BET151 | 0.000 | 0.000 | uM | 72 | hr | 2 | 3588 | 188 | 0.9745 | 1.0000 | 0.0524 | 0.0549 |
| WM-115 | Vemurafenib | I-BET151 | 0.000 | 0.000 | uM | 72 | hr | 3 | 3651 | 201 | 0.9888 | 1.0000 | 0.0551 | 0.0549 |
| WM-115 | Vemurafenib | I-BET151 | 0.000 | 1.000 | uM | 72 | hr | 1 | 3143 | 166 | 0.8533 | 0.7766 | 0.0528 | 0.0532 |
| WM-115 | Vemurafenib | I-BET151 | 0.000 | 1.000 | uM | 72 | hr | 2 | 2815 | 155 | 0.7624 | 0.7766 | 0.0551 | 0.0532 |
| WM-115 | Vemurafenib | I-BET151 | 0.000 | 1.000 | uM | 72 | hr | 3 | 2628 | 136 | 0.7142 | 0.7766 | 0.0518 | 0.0532 |
| WM-115 | Vemurafenib | I-BET151 | 0.100 | 0.000 | uM | 72 | hr | 1 | 3335 | 176 | 0.9054 | 0.9074 | 0.0528 | 0.0514 |
| WM-115 | Vemurafenib | I-BET151 | 0.100 | 0.000 | uM | 72 | hr | 2 | 3303 | 164 | 0.8997 | 0.9074 | 0.0497 | 0.0514 |
| WM-115 | Vemurafenib | I-BET151 | 0.100 | 0.000 | uM | 72 | hr | 3 | 3375 | 175 | 0.9172 | 0.9074 | 0.0519 | 0.0514 |
| WM-115 | Vemurafenib | I-BET151 | 0.100 | 1.000 | uM | 72 | hr | 1 | 2500 | 503 | 0.5724 | 0.5488 | 0.2012 | 0.2039 |
| WM-115 | Vemurafenib | I-BET151 | 0.100 | 1.000 | uM | 72 | hr | 2 | 2496 | 510 | 0.5692 | 0.5488 | 0.2043 | 0.2039 |
| WM-115 | Vemurafenib | I-BET151 | 0.100 | 1.000 | uM | 72 | hr | 3 | 2218 | 457 | 0.5047 | 0.5488 | 0.2060 | 0.2039 |
| WM-115 | Vemurafenib | I-BET151 | 0.316 | 0.000 | uM | 72 | hr | 1 | 2860 | 182 | 0.7676 | 0.7662 | 0.0636 | 0.0650 |
| WM-115 | Vemurafenib | I-BET151 | 0.316 | 0.000 | uM | 72 | hr | 2 | 2905 | 193 | 0.7773 | 0.7662 | 0.0664 | 0.0650 |
| WM-115 | Vemurafenib | I-BET151 | 0.316 | 0.000 | uM | 72 | hr | 3 | 2813 | 183 | 0.7538 | 0.7662 | 0.0651 | 0.0650 |
| WM-115 | Vemurafenib | I-BET151 | 0.316 | 1.000 | uM | 72 | hr | 1 | 2086 | 743 | 0.3849 | 0.3504 | 0.3562 | 0.3582 |
| WM-115 | Vemurafenib | I-BET151 | 0.316 | 1.000 | uM | 72 | hr | 2 | 1893 | 658 | 0.3540 | 0.3504 | 0.3476 | 0.3582 |
| WM-115 | Vemurafenib | I-BET151 | 0.316 | 1.000 | uM | 72 | hr | 3 | 1732 | 642 | 0.3124 | 0.3504 | 0.3707 | 0.3582 |
| WM-115 | Vemurafenib | I-BET151 | 1.000 | 0.000 | uM | 72 | hr | 1 | 2502 | 258 | 0.6432 | 0.6389 | 0.1031 | 0.1025 |
| WM-115 | Vemurafenib | I-BET151 | 1.000 | 0.000 | uM | 72 | hr | 2 | 2545 | 261 | 0.6546 | 0.6389 | 0.1026 | 0.1025 |