Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)
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Cell | Small Molecule 1 | Small Molecule 2 | Small Mol 1 Concentration | Small Mol 2 Concentration | Small Mol Conc Unit | Time Point | Time Point Unit | Replicate | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction |
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A-375 | Vemurafenib | I-BET151 | 0.100 | 1.000 | uM | 72 | hr | 2 | 4119 | 181 | 0.2846 | 0.2971 | 0.0439 | 0.0480 |
A-375 | Vemurafenib | I-BET151 | 0.100 | 1.000 | uM | 72 | hr | 3 | 4187 | 229 | 0.2861 | 0.2971 | 0.0547 | 0.0480 |
A-375 | Vemurafenib | I-BET151 | 0.316 | 0.000 | uM | 72 | hr | 1 | 4295 | 145 | 0.3000 | 0.3027 | 0.0338 | 0.0319 |
A-375 | Vemurafenib | I-BET151 | 0.316 | 0.000 | uM | 72 | hr | 2 | 4409 | 152 | 0.3077 | 0.3027 | 0.0345 | 0.0319 |
A-375 | Vemurafenib | I-BET151 | 0.316 | 0.000 | uM | 72 | hr | 3 | 4274 | 117 | 0.3005 | 0.3027 | 0.0274 | 0.0319 |
A-375 | Vemurafenib | I-BET151 | 0.316 | 1.000 | uM | 72 | hr | 1 | 2938 | 245 | 0.1947 | 0.1801 | 0.0834 | 0.0950 |
A-375 | Vemurafenib | I-BET151 | 0.316 | 1.000 | uM | 72 | hr | 2 | 2781 | 281 | 0.1807 | 0.1801 | 0.1010 | 0.0950 |
A-375 | Vemurafenib | I-BET151 | 0.316 | 1.000 | uM | 72 | hr | 3 | 2535 | 255 | 0.1648 | 0.1801 | 0.1006 | 0.0950 |
A-375 | Vemurafenib | I-BET151 | 1.000 | 0.000 | uM | 72 | hr | 1 | 2818 | 143 | 0.1934 | 0.2025 | 0.0507 | 0.0473 |
A-375 | Vemurafenib | I-BET151 | 1.000 | 0.000 | uM | 72 | hr | 2 | 2935 | 165 | 0.2002 | 0.2025 | 0.0562 | 0.0473 |
A-375 | Vemurafenib | I-BET151 | 1.000 | 0.000 | uM | 72 | hr | 3 | 3066 | 107 | 0.2139 | 0.2025 | 0.0349 | 0.0473 |
A-375 | Vemurafenib | I-BET151 | 1.000 | 1.000 | uM | 72 | hr | 1 | 2247 | 437 | 0.1308 | 0.1218 | 0.1945 | 0.1892 |
A-375 | Vemurafenib | I-BET151 | 1.000 | 1.000 | uM | 72 | hr | 2 | 2175 | 439 | 0.1255 | 0.1218 | 0.2018 | 0.1892 |
A-375 | Vemurafenib | I-BET151 | 1.000 | 1.000 | uM | 72 | hr | 3 | 1822 | 312 | 0.1091 | 0.1218 | 0.1712 | 0.1892 |
A-375 | Vemurafenib | I-BET151 | 3.160 | 0.000 | uM | 72 | hr | 1 | 2262 | 163 | 0.1517 | 0.1530 | 0.0721 | 0.0928 |
A-375 | Vemurafenib | I-BET151 | 3.160 | 0.000 | uM | 72 | hr | 2 | 2319 | 226 | 0.1513 | 0.1530 | 0.0975 | 0.0928 |
A-375 | Vemurafenib | I-BET151 | 3.160 | 0.000 | uM | 72 | hr | 3 | 2422 | 264 | 0.1560 | 0.1530 | 0.1090 | 0.0928 |
A-375 | Vemurafenib | I-BET151 | 3.160 | 1.000 | uM | 72 | hr | 1 | 2097 | 686 | 0.1020 | 0.0884 | 0.3271 | 0.3475 |
A-375 | Vemurafenib | I-BET151 | 3.160 | 1.000 | uM | 72 | hr | 2 | 1858 | 649 | 0.0874 | 0.0884 | 0.3493 | 0.3475 |
A-375 | Vemurafenib | I-BET151 | 3.160 | 1.000 | uM | 72 | hr | 3 | 1653 | 605 | 0.0758 | 0.0884 | 0.3660 | 0.3475 |
COLO 858 | Vemurafenib | (+)-JQ1 | 0.000 | 0.000 | uM | 72 | hr | 1 | 3788 | 589 | 0.9711 | 1.0000 | 0.1555 | 0.1585 |
COLO 858 | Vemurafenib | (+)-JQ1 | 0.000 | 0.000 | uM | 72 | hr | 2 | 3899 | 617 | 0.9963 | 1.0000 | 0.1582 | 0.1585 |
COLO 858 | Vemurafenib | (+)-JQ1 | 0.000 | 0.000 | uM | 72 | hr | 3 | 4059 | 657 | 1.0327 | 1.0000 | 0.1619 | 0.1585 |
COLO 858 | Vemurafenib | (+)-JQ1 | 0.000 | 1.000 | uM | 72 | hr | 1 | 1181 | 405 | 0.2356 | 0.1822 | 0.3429 | 0.4375 |
COLO 858 | Vemurafenib | (+)-JQ1 | 0.000 | 1.000 | uM | 72 | hr | 2 | 904 | 415 | 0.1484 | 0.1822 | 0.4591 | 0.4375 |