Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)
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| Cell | Small Molecule 1 | Small Molecule 2 | Small Mol 1 Concentration | Small Mol 2 Concentration | Small Mol Conc Unit | Time Point | Time Point Unit | Replicate | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| A-375 | Vemurafenib | Belinostat | 1.000 | 0.000 | uM | 72 | hr | 3 | 2740 | 120 | 0.2000 | 0.1917 | 0.0438 | 0.0580 |
| A-375 | Vemurafenib | Belinostat | 1.000 | 1.000 | uM | 72 | hr | 1 | 1476 | 819 | 0.0502 | 0.0489 | 0.5549 | 0.5357 |
| A-375 | Vemurafenib | Belinostat | 1.000 | 1.000 | uM | 72 | hr | 2 | 1406 | 767 | 0.0488 | 0.0489 | 0.5455 | 0.5357 |
| A-375 | Vemurafenib | Belinostat | 1.000 | 1.000 | uM | 72 | hr | 3 | 1267 | 642 | 0.0477 | 0.0489 | 0.5067 | 0.5357 |
| A-375 | Vemurafenib | Belinostat | 3.160 | 0.000 | uM | 72 | hr | 1 | 2164 | 160 | 0.1530 | 0.1495 | 0.0739 | 0.0897 |
| A-375 | Vemurafenib | Belinostat | 3.160 | 0.000 | uM | 72 | hr | 2 | 2130 | 167 | 0.1499 | 0.1495 | 0.0784 | 0.0897 |
| A-375 | Vemurafenib | Belinostat | 3.160 | 0.000 | uM | 72 | hr | 3 | 2158 | 252 | 0.1455 | 0.1495 | 0.1168 | 0.0897 |
| A-375 | Vemurafenib | Belinostat | 3.160 | 1.000 | uM | 72 | hr | 1 | 1468 | 826 | 0.0490 | 0.0484 | 0.5627 | 0.5323 |
| A-375 | Vemurafenib | Belinostat | 3.160 | 1.000 | uM | 72 | hr | 2 | 1407 | 591 | 0.0623 | 0.0484 | 0.4200 | 0.5323 |
| A-375 | Vemurafenib | Belinostat | 3.160 | 1.000 | uM | 72 | hr | 3 | 1148 | 705 | 0.0338 | 0.0484 | 0.6141 | 0.5323 |
| A-375 | Vemurafenib | I-BET | 0.000 | 0.000 | uM | 72 | hr | 1 | 16558 | 1621 | 1.0954 | 1.0000 | 0.0979 | 0.1030 |
| A-375 | Vemurafenib | I-BET | 0.000 | 0.000 | uM | 72 | hr | 2 | 14872 | 1575 | 0.9751 | 1.0000 | 0.1059 | 0.1030 |
| A-375 | Vemurafenib | I-BET | 0.000 | 0.000 | uM | 72 | hr | 3 | 14167 | 1492 | 0.9295 | 1.0000 | 0.1053 | 0.1030 |
| A-375 | Vemurafenib | I-BET | 0.000 | 1.000 | uM | 72 | hr | 1 | 10559 | 1087 | 0.6946 | 0.6207 | 0.1029 | 0.0779 |
| A-375 | Vemurafenib | I-BET | 0.000 | 1.000 | uM | 72 | hr | 2 | 8833 | 891 | 0.5824 | 0.6207 | 0.1009 | 0.0779 |
| A-375 | Vemurafenib | I-BET | 0.000 | 1.000 | uM | 72 | hr | 3 | 8225 | 247 | 0.5851 | 0.6207 | 0.0300 | 0.0779 |
| A-375 | Vemurafenib | I-BET | 0.100 | 0.000 | uM | 72 | hr | 1 | 7074 | 233 | 0.5017 | 0.5189 | 0.0329 | 0.0308 |
| A-375 | Vemurafenib | I-BET | 0.100 | 0.000 | uM | 72 | hr | 2 | 7497 | 228 | 0.5331 | 0.5189 | 0.0304 | 0.0308 |
| A-375 | Vemurafenib | I-BET | 0.100 | 0.000 | uM | 72 | hr | 3 | 7332 | 213 | 0.5221 | 0.5189 | 0.0291 | 0.0308 |
| A-375 | Vemurafenib | I-BET | 0.100 | 1.000 | uM | 72 | hr | 1 | 4909 | 225 | 0.3435 | 0.3080 | 0.0458 | 0.0484 |
| A-375 | Vemurafenib | I-BET | 0.100 | 1.000 | uM | 72 | hr | 2 | 4395 | 227 | 0.3057 | 0.3080 | 0.0516 | 0.0484 |
| A-375 | Vemurafenib | I-BET | 0.100 | 1.000 | uM | 72 | hr | 3 | 3934 | 188 | 0.2747 | 0.3080 | 0.0478 | 0.0484 |
| A-375 | Vemurafenib | I-BET | 0.316 | 0.000 | uM | 72 | hr | 1 | 4169 | 116 | 0.2972 | 0.2900 | 0.0278 | 0.0255 |
| A-375 | Vemurafenib | I-BET | 0.316 | 0.000 | uM | 72 | hr | 2 | 4081 | 75 | 0.2938 | 0.2900 | 0.0184 | 0.0255 |
| A-375 | Vemurafenib | I-BET | 0.316 | 0.000 | uM | 72 | hr | 3 | 3925 | 119 | 0.2791 | 0.2900 | 0.0303 | 0.0255 |