Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)
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| Cell | Small Molecule 1 | Small Molecule 2 | Small Mol 1 Concentration | Small Mol 2 Concentration | Small Mol Conc Unit | Time Point | Time Point Unit | Replicate | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WM-115 | Vemurafenib | PF562271 | 1.000 | 3.160 | uM | 72 | hr | 1 | 1389 | 297 | 0.2952 | 0.2489 | 0.2138 | 0.2632 |
| WM-115 | Vemurafenib | PF562271 | 1.000 | 3.160 | uM | 72 | hr | 2 | 1195 | 342 | 0.2306 | 0.2489 | 0.2862 | 0.2632 |
| WM-115 | Vemurafenib | PF562271 | 1.000 | 3.160 | uM | 72 | hr | 3 | 1150 | 333 | 0.2209 | 0.2489 | 0.2896 | 0.2632 |
| WM-115 | Vemurafenib | PF562271 | 3.160 | 0.000 | uM | 72 | hr | 1 | 1889 | 410 | 0.3998 | 0.4048 | 0.2170 | 0.2305 |
| WM-115 | Vemurafenib | PF562271 | 3.160 | 0.000 | uM | 72 | hr | 2 | 1857 | 450 | 0.3803 | 0.4048 | 0.2423 | 0.2305 |
| WM-115 | Vemurafenib | PF562271 | 3.160 | 0.000 | uM | 72 | hr | 3 | 2093 | 486 | 0.4344 | 0.4048 | 0.2322 | 0.2305 |
| WM-115 | Vemurafenib | PF562271 | 3.160 | 0.316 | uM | 72 | hr | 1 | 1559 | 395 | 0.3147 | 0.2955 | 0.2534 | 0.2762 |
| WM-115 | Vemurafenib | PF562271 | 3.160 | 0.316 | uM | 72 | hr | 2 | 1530 | 410 | 0.3028 | 0.2955 | 0.2680 | 0.2762 |
| WM-115 | Vemurafenib | PF562271 | 3.160 | 0.316 | uM | 72 | hr | 3 | 1438 | 442 | 0.2692 | 0.2955 | 0.3074 | 0.2762 |
| WM-115 | Vemurafenib | PF562271 | 3.160 | 1.000 | uM | 72 | hr | 1 | 1529 | 467 | 0.2871 | 0.2709 | 0.3054 | 0.2810 |
| WM-115 | Vemurafenib | PF562271 | 3.160 | 1.000 | uM | 72 | hr | 2 | 1447 | 427 | 0.2757 | 0.2709 | 0.2951 | 0.2810 |
| WM-115 | Vemurafenib | PF562271 | 3.160 | 1.000 | uM | 72 | hr | 3 | 1221 | 296 | 0.2500 | 0.2709 | 0.2424 | 0.2810 |
| WM-115 | Vemurafenib | PF562271 | 3.160 | 3.160 | uM | 72 | hr | 1 | 1241 | 349 | 0.2411 | 0.2112 | 0.2812 | 0.3403 |
| WM-115 | Vemurafenib | PF562271 | 3.160 | 3.160 | uM | 72 | hr | 2 | 1197 | 458 | 0.1998 | 0.2112 | 0.3826 | 0.3403 |
| WM-115 | Vemurafenib | PF562271 | 3.160 | 3.160 | uM | 72 | hr | 3 | 1109 | 396 | 0.1927 | 0.2112 | 0.3571 | 0.3403 |
| WM-115 | Vemurafenib | Saracatinib | 0.000 | 0.000 | uM | 72 | hr | 1 | 4061 | 252 | 0.9905 | 1.0000 | 0.0621 | 0.0586 |
| WM-115 | Vemurafenib | Saracatinib | 0.000 | 0.000 | uM | 72 | hr | 2 | 4307 | 267 | 1.0505 | 1.0000 | 0.0620 | 0.0586 |
| WM-115 | Vemurafenib | Saracatinib | 0.000 | 0.000 | uM | 72 | hr | 3 | 3889 | 201 | 0.9590 | 1.0000 | 0.0517 | 0.0586 |
| WM-115 | Vemurafenib | Saracatinib | 0.000 | 0.316 | uM | 72 | hr | 1 | 3787 | 264 | 0.9161 | 0.9211 | 0.0697 | 0.0646 |
| WM-115 | Vemurafenib | Saracatinib | 0.000 | 0.316 | uM | 72 | hr | 2 | 3794 | 219 | 0.9296 | 0.9211 | 0.0577 | 0.0646 |
| WM-115 | Vemurafenib | Saracatinib | 0.000 | 0.316 | uM | 72 | hr | 3 | 3780 | 251 | 0.9177 | 0.9211 | 0.0664 | 0.0646 |
| WM-115 | Vemurafenib | Saracatinib | 0.000 | 1.000 | uM | 72 | hr | 1 | 3051 | 212 | 0.7382 | 0.7584 | 0.0695 | 0.0699 |
| WM-115 | Vemurafenib | Saracatinib | 0.000 | 1.000 | uM | 72 | hr | 2 | 3266 | 231 | 0.7892 | 0.7584 | 0.0707 | 0.0699 |
| WM-115 | Vemurafenib | Saracatinib | 0.000 | 1.000 | uM | 72 | hr | 3 | 3091 | 215 | 0.7479 | 0.7584 | 0.0696 | 0.0699 |
| WM-115 | Vemurafenib | Saracatinib | 0.000 | 3.160 | uM | 72 | hr | 1 | 3005 | 240 | 0.7190 | 0.6962 | 0.0799 | 0.0731 |