Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)
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| Cell | Small Molecule 1 | Small Molecule 2 | Small Mol 1 Concentration | Small Mol 2 Concentration | Small Mol Conc Unit | Time Point | Time Point Unit | Replicate | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WM-115 | Vemurafenib | PF562271 | 0.100 | 1.000 | uM | 72 | hr | 3 | 2419 | 174 | 0.6069 | 0.6104 | 0.0719 | 0.0822 |
| WM-115 | Vemurafenib | PF562271 | 0.100 | 3.160 | uM | 72 | hr | 1 | 1737 | 419 | 0.3563 | 0.3373 | 0.2412 | 0.2340 |
| WM-115 | Vemurafenib | PF562271 | 0.100 | 3.160 | uM | 72 | hr | 2 | 1597 | 372 | 0.3311 | 0.3373 | 0.2329 | 0.2340 |
| WM-115 | Vemurafenib | PF562271 | 0.100 | 3.160 | uM | 72 | hr | 3 | 1554 | 354 | 0.3244 | 0.3373 | 0.2278 | 0.2340 |
| WM-115 | Vemurafenib | PF562271 | 0.316 | 0.000 | uM | 72 | hr | 1 | 2666 | 221 | 0.6609 | 0.6725 | 0.0829 | 0.0853 |
| WM-115 | Vemurafenib | PF562271 | 0.316 | 0.000 | uM | 72 | hr | 2 | 2673 | 233 | 0.6596 | 0.6725 | 0.0872 | 0.0853 |
| WM-115 | Vemurafenib | PF562271 | 0.316 | 0.000 | uM | 72 | hr | 3 | 2820 | 242 | 0.6969 | 0.6725 | 0.0858 | 0.0853 |
| WM-115 | Vemurafenib | PF562271 | 0.316 | 0.316 | uM | 72 | hr | 1 | 2509 | 271 | 0.6050 | 0.5986 | 0.1080 | 0.1096 |
| WM-115 | Vemurafenib | PF562271 | 0.316 | 0.316 | uM | 72 | hr | 2 | 2410 | 274 | 0.5774 | 0.5986 | 0.1137 | 0.1096 |
| WM-115 | Vemurafenib | PF562271 | 0.316 | 0.316 | uM | 72 | hr | 3 | 2541 | 272 | 0.6134 | 0.5986 | 0.1070 | 0.1096 |
| WM-115 | Vemurafenib | PF562271 | 0.316 | 1.000 | uM | 72 | hr | 1 | 2319 | 335 | 0.5363 | 0.5150 | 0.1445 | 0.1216 |
| WM-115 | Vemurafenib | PF562271 | 0.316 | 1.000 | uM | 72 | hr | 2 | 2094 | 209 | 0.5096 | 0.5150 | 0.0998 | 0.1216 |
| WM-115 | Vemurafenib | PF562271 | 0.316 | 1.000 | uM | 72 | hr | 3 | 2099 | 253 | 0.4990 | 0.5150 | 0.1205 | 0.1216 |
| WM-115 | Vemurafenib | PF562271 | 0.316 | 3.160 | uM | 72 | hr | 1 | 1524 | 432 | 0.2952 | 0.2794 | 0.2835 | 0.2745 |
| WM-115 | Vemurafenib | PF562271 | 0.316 | 3.160 | uM | 72 | hr | 2 | 1421 | 396 | 0.2771 | 0.2794 | 0.2787 | 0.2745 |
| WM-115 | Vemurafenib | PF562271 | 0.316 | 3.160 | uM | 72 | hr | 3 | 1332 | 348 | 0.2660 | 0.2794 | 0.2613 | 0.2745 |
| WM-115 | Vemurafenib | PF562271 | 1.000 | 0.000 | uM | 72 | hr | 1 | 2456 | 346 | 0.5704 | 0.5678 | 0.1409 | 0.1426 |
| WM-115 | Vemurafenib | PF562271 | 1.000 | 0.000 | uM | 72 | hr | 2 | 2444 | 377 | 0.5587 | 0.5678 | 0.1543 | 0.1426 |
| WM-115 | Vemurafenib | PF562271 | 1.000 | 0.000 | uM | 72 | hr | 3 | 2449 | 325 | 0.5742 | 0.5678 | 0.1327 | 0.1426 |
| WM-115 | Vemurafenib | PF562271 | 1.000 | 0.316 | uM | 72 | hr | 1 | 2021 | 347 | 0.4525 | 0.4481 | 0.1717 | 0.1607 |
| WM-115 | Vemurafenib | PF562271 | 1.000 | 0.316 | uM | 72 | hr | 2 | 1895 | 293 | 0.4331 | 0.4481 | 0.1546 | 0.1607 |
| WM-115 | Vemurafenib | PF562271 | 1.000 | 0.316 | uM | 72 | hr | 3 | 2010 | 313 | 0.4587 | 0.4481 | 0.1557 | 0.1607 |
| WM-115 | Vemurafenib | PF562271 | 1.000 | 1.000 | uM | 72 | hr | 1 | 1782 | 333 | 0.3917 | 0.3790 | 0.1869 | 0.1994 |
| WM-115 | Vemurafenib | PF562271 | 1.000 | 1.000 | uM | 72 | hr | 2 | 1812 | 365 | 0.3912 | 0.3790 | 0.2014 | 0.1994 |
| WM-115 | Vemurafenib | PF562271 | 1.000 | 1.000 | uM | 72 | hr | 3 | 1658 | 348 | 0.3541 | 0.3790 | 0.2099 | 0.1994 |