Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)
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Cell | Small Molecule 1 | Small Molecule 2 | Small Mol 1 Concentration | Small Mol 2 Concentration | Small Mol Conc Unit | Time Point | Time Point Unit | Replicate | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction |
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COLO 858 | Vemurafenib | Saracatinib | 0.000 | 3.160 | uM | 72 | hr | 2 | 3265 | 654 | 0.4423 | 0.4762 | 0.2003 | 0.1912 |
COLO 858 | Vemurafenib | Saracatinib | 0.000 | 3.160 | uM | 72 | hr | 3 | 3266 | 585 | 0.4542 | 0.4762 | 0.1791 | 0.1912 |
COLO 858 | Vemurafenib | Saracatinib | 0.100 | 0.000 | uM | 72 | hr | 1 | 3035 | 258 | 0.4704 | 0.4664 | 0.0850 | 0.0871 |
COLO 858 | Vemurafenib | Saracatinib | 0.100 | 0.000 | uM | 72 | hr | 2 | 3307 | 346 | 0.5016 | 0.4664 | 0.1046 | 0.0871 |
COLO 858 | Vemurafenib | Saracatinib | 0.100 | 0.000 | uM | 72 | hr | 3 | 2717 | 195 | 0.4272 | 0.4664 | 0.0718 | 0.0871 |
COLO 858 | Vemurafenib | Saracatinib | 0.100 | 0.316 | uM | 72 | hr | 1 | 1779 | 327 | 0.2460 | 0.2723 | 0.1838 | 0.1881 |
COLO 858 | Vemurafenib | Saracatinib | 0.100 | 0.316 | uM | 72 | hr | 2 | 1893 | 364 | 0.2590 | 0.2723 | 0.1923 | 0.1881 |
COLO 858 | Vemurafenib | Saracatinib | 0.100 | 0.316 | uM | 72 | hr | 3 | 2269 | 427 | 0.3120 | 0.2723 | 0.1882 | 0.1881 |
COLO 858 | Vemurafenib | Saracatinib | 0.100 | 1.000 | uM | 72 | hr | 1 | 1775 | 484 | 0.2187 | 0.3290 | 0.2727 | 0.2076 |
COLO 858 | Vemurafenib | Saracatinib | 0.100 | 1.000 | uM | 72 | hr | 2 | 1561 | 404 | 0.1960 | 0.3290 | 0.2588 | 0.2076 |
COLO 858 | Vemurafenib | Saracatinib | 0.100 | 1.000 | uM | 72 | hr | 3 | 3719 | 340 | 0.5724 | 0.3290 | 0.0914 | 0.2076 |
COLO 858 | Vemurafenib | Saracatinib | 0.100 | 3.160 | uM | 72 | hr | 1 | 1836 | 631 | 0.2041 | 0.1780 | 0.3437 | 0.3147 |
COLO 858 | Vemurafenib | Saracatinib | 0.100 | 3.160 | uM | 72 | hr | 2 | 1555 | 466 | 0.1845 | 0.1780 | 0.2997 | 0.3147 |
COLO 858 | Vemurafenib | Saracatinib | 0.100 | 3.160 | uM | 72 | hr | 3 | 1227 | 369 | 0.1453 | 0.1780 | 0.3007 | 0.3147 |
COLO 858 | Vemurafenib | Saracatinib | 0.316 | 0.000 | uM | 72 | hr | 1 | 1927 | 309 | 0.2741 | 0.2997 | 0.1604 | 0.1642 |
COLO 858 | Vemurafenib | Saracatinib | 0.316 | 0.000 | uM | 72 | hr | 2 | 2213 | 406 | 0.3061 | 0.2997 | 0.1835 | 0.1642 |
COLO 858 | Vemurafenib | Saracatinib | 0.316 | 0.000 | uM | 72 | hr | 3 | 2212 | 329 | 0.3190 | 0.2997 | 0.1487 | 0.1642 |
COLO 858 | Vemurafenib | Saracatinib | 0.316 | 0.316 | uM | 72 | hr | 1 | 1226 | 503 | 0.1225 | 0.1170 | 0.4103 | 0.4614 |
COLO 858 | Vemurafenib | Saracatinib | 0.316 | 0.316 | uM | 72 | hr | 2 | 1185 | 610 | 0.0974 | 0.1170 | 0.5148 | 0.4614 |
COLO 858 | Vemurafenib | Saracatinib | 0.316 | 0.316 | uM | 72 | hr | 3 | 1431 | 657 | 0.1311 | 0.1170 | 0.4591 | 0.4614 |
COLO 858 | Vemurafenib | Saracatinib | 0.316 | 1.000 | uM | 72 | hr | 1 | 1252 | 737 | 0.0872 | 0.0840 | 0.5887 | 0.5773 |
COLO 858 | Vemurafenib | Saracatinib | 0.316 | 1.000 | uM | 72 | hr | 2 | 1129 | 649 | 0.0813 | 0.0840 | 0.5748 | 0.5773 |
COLO 858 | Vemurafenib | Saracatinib | 0.316 | 1.000 | uM | 72 | hr | 3 | 1140 | 648 | 0.0833 | 0.0840 | 0.5684 | 0.5773 |
COLO 858 | Vemurafenib | Saracatinib | 0.316 | 3.160 | uM | 72 | hr | 1 | 1128 | 750 | 0.0640 | 0.0618 | 0.6649 | 0.6473 |
COLO 858 | Vemurafenib | Saracatinib | 0.316 | 3.160 | uM | 72 | hr | 2 | 934 | 591 | 0.0581 | 0.0618 | 0.6328 | 0.6473 |