Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib PF562271 1.000 3.160
uM
 72
hr
 1 595 559 0.0065 0.0058 0.9395 0.9416
COLO 858 Vemurafenib PF562271 1.000 3.160
uM
 72
hr
 2 561 526 0.0063 0.0058 0.9376 0.9416
COLO 858 Vemurafenib PF562271 1.000 3.160
uM
 72
hr
 3 477 452 0.0045 0.0058 0.9476 0.9416
COLO 858 Vemurafenib PF562271 3.160 0.000
uM
 72
hr
 1 1042 801 0.0435 0.0334 0.7687 0.8371
COLO 858 Vemurafenib PF562271 3.160 0.000
uM
 72
hr
 2 1199 1034 0.0298 0.0334 0.8624 0.8371
COLO 858 Vemurafenib PF562271 3.160 0.000
uM
 72
hr
 3 1251 1101 0.0271 0.0334 0.8801 0.8371
COLO 858 Vemurafenib PF562271 3.160 0.316
uM
 72
hr
 1 712 628 0.0151 0.0125 0.8820 0.9029
COLO 858 Vemurafenib PF562271 3.160 0.316
uM
 72
hr
 2 639 572 0.0121 0.0125 0.8951 0.9029
COLO 858 Vemurafenib PF562271 3.160 0.316
uM
 72
hr
 3 833 776 0.0103 0.0125 0.9316 0.9029
COLO 858 Vemurafenib PF562271 3.160 1.000
uM
 72
hr
 1 1199 1142 0.0103 0.0092 0.9525 0.9423
COLO 858 Vemurafenib PF562271 3.160 1.000
uM
 72
hr
 2 832 777 0.0099 0.0092 0.9339 0.9423
COLO 858 Vemurafenib PF562271 3.160 1.000
uM
 72
hr
 3 688 647 0.0074 0.0092 0.9404 0.9423
COLO 858 Vemurafenib PF562271 3.160 3.160
uM
 72
hr
 1 486 455 0.0056 0.0041 0.9362 0.9488
COLO 858 Vemurafenib PF562271 3.160 3.160
uM
 72
hr
 2 424 402 0.0040 0.0041 0.9481 0.9488
COLO 858 Vemurafenib PF562271 3.160 3.160
uM
 72
hr
 3 422 406 0.0029 0.0041 0.9621 0.9488
COLO 858 Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 1 7209 989 1.0536 1.0000 0.1372 0.1369
COLO 858 Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 2 6958 942 1.0191 1.0000 0.1354 0.1369
COLO 858 Vemurafenib Saracatinib 0.000 0.000
uM
 72
hr
 3 6352 878 0.9273 1.0000 0.1382 0.1369
COLO 858 Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 1 5195 826 0.7401 0.8239 0.1590 0.1662
COLO 858 Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 2 5368 976 0.7440 0.8239 0.1818 0.1662
COLO 858 Vemurafenib Saracatinib 0.000 0.316
uM
 72
hr
 3 6922 1092 0.9876 0.8239 0.1578 0.1662
COLO 858 Vemurafenib Saracatinib 0.000 1.000
uM
 72
hr
 1 3740 546 0.5411 0.5771 0.1460 0.1387
COLO 858 Vemurafenib Saracatinib 0.000 1.000
uM
 72
hr
 2 3833 559 0.5546 0.5771 0.1458 0.1387
COLO 858 Vemurafenib Saracatinib 0.000 1.000
uM
 72
hr
 3 4284 532 0.6356 0.5771 0.1242 0.1387
COLO 858 Vemurafenib Saracatinib 0.000 3.160
uM
 72
hr
 1 3899 757 0.5322 0.4762 0.1942 0.1912