Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)

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Cell Small Molecule 1 Small Molecule 2 Small Mol 1 Concentration Small Mol 2 Concentration Small Mol Conc Unit Time Point Time Point Unit Replicate Total Number of Cells (Nuclei) Number of Apoptotic Cells Relative Viability Mean Relative Viability Apoptosis Fraction Mean Apoptosis Fraction
COLO 858 Vemurafenib PF562271 0.100 1.000
uM
 72
hr
 3 1142 316 0.1490 0.1528 0.2767 0.2918
COLO 858 Vemurafenib PF562271 0.100 3.160
uM
 72
hr
 1 912 724 0.0339 0.0290 0.7939 0.7843
COLO 858 Vemurafenib PF562271 0.100 3.160
uM
 72
hr
 2 723 550 0.0312 0.0290 0.7607 0.7843
COLO 858 Vemurafenib PF562271 0.100 3.160
uM
 72
hr
 3 600 479 0.0218 0.0290 0.7983 0.7843
COLO 858 Vemurafenib PF562271 0.316 0.000
uM
 72
hr
 1 1748 230 0.2738 0.2879 0.1316 0.1549
COLO 858 Vemurafenib PF562271 0.316 0.000
uM
 72
hr
 2 1817 313 0.2712 0.2879 0.1723 0.1549
COLO 858 Vemurafenib PF562271 0.316 0.000
uM
 72
hr
 3 2106 339 0.3187 0.2879 0.1610 0.1549
COLO 858 Vemurafenib PF562271 0.316 0.316
uM
 72
hr
 1 1301 460 0.1517 0.1439 0.3536 0.3763
COLO 858 Vemurafenib PF562271 0.316 0.316
uM
 72
hr
 2 1253 524 0.1315 0.1439 0.4182 0.3763
COLO 858 Vemurafenib PF562271 0.316 0.316
uM
 72
hr
 3 1280 457 0.1484 0.1439 0.3570 0.3763
COLO 858 Vemurafenib PF562271 0.316 1.000
uM
 72
hr
 1 1035 564 0.0849 0.0793 0.5449 0.5384
COLO 858 Vemurafenib PF562271 0.316 1.000
uM
 72
hr
 2 956 466 0.0884 0.0793 0.4874 0.5384
COLO 858 Vemurafenib PF562271 0.316 1.000
uM
 72
hr
 3 858 500 0.0646 0.0793 0.5828 0.5384
COLO 858 Vemurafenib PF562271 0.316 3.160
uM
 72
hr
 1 526 473 0.0096 0.0109 0.8992 0.8930
COLO 858 Vemurafenib PF562271 0.316 3.160
uM
 72
hr
 2 670 585 0.0153 0.0109 0.8731 0.8930
COLO 858 Vemurafenib PF562271 0.316 3.160
uM
 72
hr
 3 471 427 0.0079 0.0109 0.9066 0.8930
COLO 858 Vemurafenib PF562271 1.000 0.000
uM
 72
hr
 1 1250 489 0.1372 0.1377 0.3912 0.4424
COLO 858 Vemurafenib PF562271 1.000 0.000
uM
 72
hr
 2 1366 641 0.1307 0.1377 0.4693 0.4424
COLO 858 Vemurafenib PF562271 1.000 0.000
uM
 72
hr
 3 1510 705 0.1452 0.1377 0.4669 0.4424
COLO 858 Vemurafenib PF562271 1.000 0.316
uM
 72
hr
 1 1154 797 0.0644 0.0514 0.6906 0.7028
COLO 858 Vemurafenib PF562271 1.000 0.316
uM
 72
hr
 2 921 673 0.0447 0.0514 0.7307 0.7028
COLO 858 Vemurafenib PF562271 1.000 0.316
uM
 72
hr
 3 799 549 0.0451 0.0514 0.6871 0.7028
COLO 858 Vemurafenib PF562271 1.000 1.000
uM
 72
hr
 1 942 775 0.0301 0.0248 0.8227 0.8407
COLO 858 Vemurafenib PF562271 1.000 1.000
uM
 72
hr
 2 833 687 0.0263 0.0248 0.8247 0.8407
COLO 858 Vemurafenib PF562271 1.000 1.000
uM
 72
hr
 3 790 691 0.0179 0.0248 0.8747 0.8407