Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)
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| Cell | Small Molecule 1 | Small Molecule 2 | Small Mol 1 Concentration | Small Mol 2 Concentration | Small Mol Conc Unit | Time Point | Time Point Unit | Replicate | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WM-115 | Vemurafenib | Defactinib | 1.000 | 0.316 | uM | 72 | hr | 2 | 2077 | 325 | 0.4188 | 0.4339 | 0.1565 | 0.1684 |
| WM-115 | Vemurafenib | Defactinib | 1.000 | 0.316 | uM | 72 | hr | 3 | 2150 | 383 | 0.4224 | 0.4339 | 0.1781 | 0.1684 |
| WM-115 | Vemurafenib | Defactinib | 1.000 | 1.000 | uM | 72 | hr | 1 | 2266 | 440 | 0.4365 | 0.4181 | 0.1942 | 0.1817 |
| WM-115 | Vemurafenib | Defactinib | 1.000 | 1.000 | uM | 72 | hr | 2 | 2217 | 369 | 0.4417 | 0.4181 | 0.1664 | 0.1817 |
| WM-115 | Vemurafenib | Defactinib | 1.000 | 1.000 | uM | 72 | hr | 3 | 1929 | 356 | 0.3760 | 0.4181 | 0.1846 | 0.1817 |
| WM-115 | Vemurafenib | Defactinib | 1.000 | 3.160 | uM | 72 | hr | 1 | 1634 | 292 | 0.3208 | 0.3114 | 0.1787 | 0.1947 |
| WM-115 | Vemurafenib | Defactinib | 1.000 | 3.160 | uM | 72 | hr | 2 | 1617 | 304 | 0.3138 | 0.3114 | 0.1880 | 0.1947 |
| WM-115 | Vemurafenib | Defactinib | 1.000 | 3.160 | uM | 72 | hr | 3 | 1601 | 348 | 0.2995 | 0.3114 | 0.2174 | 0.1947 |
| WM-115 | Vemurafenib | Defactinib | 3.160 | 0.000 | uM | 72 | hr | 1 | 2072 | 591 | 0.3540 | 0.3601 | 0.2852 | 0.2576 |
| WM-115 | Vemurafenib | Defactinib | 3.160 | 0.000 | uM | 72 | hr | 2 | 1950 | 489 | 0.3492 | 0.3601 | 0.2508 | 0.2576 |
| WM-115 | Vemurafenib | Defactinib | 3.160 | 0.000 | uM | 72 | hr | 3 | 2066 | 489 | 0.3769 | 0.3601 | 0.2367 | 0.2576 |
| WM-115 | Vemurafenib | Defactinib | 3.160 | 0.316 | uM | 72 | hr | 1 | 1669 | 506 | 0.2780 | 0.2721 | 0.3032 | 0.3045 |
| WM-115 | Vemurafenib | Defactinib | 3.160 | 0.316 | uM | 72 | hr | 2 | 1634 | 466 | 0.2792 | 0.2721 | 0.2852 | 0.3045 |
| WM-115 | Vemurafenib | Defactinib | 3.160 | 0.316 | uM | 72 | hr | 3 | 1606 | 522 | 0.2591 | 0.2721 | 0.3250 | 0.3045 |
| WM-115 | Vemurafenib | Defactinib | 3.160 | 1.000 | uM | 72 | hr | 1 | 1702 | 382 | 0.3155 | 0.2864 | 0.2244 | 0.2580 |
| WM-115 | Vemurafenib | Defactinib | 3.160 | 1.000 | uM | 72 | hr | 2 | 1675 | 425 | 0.2988 | 0.2864 | 0.2537 | 0.2580 |
| WM-115 | Vemurafenib | Defactinib | 3.160 | 1.000 | uM | 72 | hr | 3 | 1454 | 430 | 0.2448 | 0.2864 | 0.2957 | 0.2580 |
| WM-115 | Vemurafenib | Defactinib | 3.160 | 3.160 | uM | 72 | hr | 1 | 1439 | 366 | 0.2565 | 0.2457 | 0.2543 | 0.2401 |
| WM-115 | Vemurafenib | Defactinib | 3.160 | 3.160 | uM | 72 | hr | 2 | 1308 | 318 | 0.2366 | 0.2457 | 0.2431 | 0.2401 |
| WM-115 | Vemurafenib | Defactinib | 3.160 | 3.160 | uM | 72 | hr | 3 | 1314 | 293 | 0.2440 | 0.2457 | 0.2230 | 0.2401 |
| WM-115 | Vemurafenib | JNK-IN-8 | 0.000 | 0.000 | uM | 72 | hr | 1 | 4350 | 233 | 1.0413 | 1.0000 | 0.0536 | 0.0576 |
| WM-115 | Vemurafenib | JNK-IN-8 | 0.000 | 0.000 | uM | 72 | hr | 2 | 4259 | 258 | 1.0120 | 1.0000 | 0.0606 | 0.0576 |
| WM-115 | Vemurafenib | JNK-IN-8 | 0.000 | 0.000 | uM | 72 | hr | 3 | 3976 | 233 | 0.9467 | 1.0000 | 0.0586 | 0.0576 |
| WM-115 | Vemurafenib | JNK-IN-8 | 0.000 | 0.316 | uM | 72 | hr | 1 | 3910 | 292 | 0.9151 | 0.9197 | 0.0747 | 0.0725 |
| WM-115 | Vemurafenib | JNK-IN-8 | 0.000 | 0.316 | uM | 72 | hr | 2 | 3870 | 269 | 0.9108 | 0.9197 | 0.0695 | 0.0725 |