Viability and apoptosis measured by imaging in BRAF(V600E/D) melanoma cell lines following treatment with combinations of two compounds (viability/apoptosis dataset 1 of 2) - Dataset (ID:20272)
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| Cell | Small Molecule 1 | Small Molecule 2 | Small Mol 1 Concentration | Small Mol 2 Concentration | Small Mol Conc Unit | Time Point | Time Point Unit | Replicate | Total Number of Cells (Nuclei) | Number of Apoptotic Cells | Relative Viability | Mean Relative Viability | Apoptosis Fraction | Mean Apoptosis Fraction |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| WM-115 | Vemurafenib | Dasatinib | 3.160 | 0.000 | uM | 72 | hr | 3 | 2042 | 430 | 0.4024 | 0.4161 | 0.2106 | 0.2078 |
| WM-115 | Vemurafenib | Dasatinib | 3.160 | 0.316 | uM | 72 | hr | 1 | 1268 | 614 | 0.1633 | 0.1543 | 0.4842 | 0.4970 |
| WM-115 | Vemurafenib | Dasatinib | 3.160 | 0.316 | uM | 72 | hr | 2 | 1191 | 569 | 0.1553 | 0.1543 | 0.4777 | 0.4970 |
| WM-115 | Vemurafenib | Dasatinib | 3.160 | 0.316 | uM | 72 | hr | 3 | 1227 | 649 | 0.1443 | 0.1543 | 0.5289 | 0.4970 |
| WM-115 | Vemurafenib | Dasatinib | 3.160 | 1.000 | uM | 72 | hr | 1 | 1241 | 575 | 0.1663 | 0.1470 | 0.4633 | 0.4830 |
| WM-115 | Vemurafenib | Dasatinib | 3.160 | 1.000 | uM | 72 | hr | 2 | 1166 | 605 | 0.1400 | 0.1470 | 0.5189 | 0.4830 |
| WM-115 | Vemurafenib | Dasatinib | 3.160 | 1.000 | uM | 72 | hr | 3 | 1013 | 473 | 0.1348 | 0.1470 | 0.4669 | 0.4830 |
| WM-115 | Vemurafenib | Dasatinib | 3.160 | 3.160 | uM | 72 | hr | 1 | 930 | 435 | 0.1236 | 0.1103 | 0.4677 | 0.5337 |
| WM-115 | Vemurafenib | Dasatinib | 3.160 | 3.160 | uM | 72 | hr | 2 | 975 | 559 | 0.1038 | 0.1103 | 0.5733 | 0.5337 |
| WM-115 | Vemurafenib | Dasatinib | 3.160 | 3.160 | uM | 72 | hr | 3 | 941 | 527 | 0.1033 | 0.1103 | 0.5600 | 0.5337 |
| WM-115 | Vemurafenib | Defactinib | 0.000 | 0.000 | uM | 72 | hr | 1 | 4435 | 257 | 0.9986 | 1.0000 | 0.0579 | 0.0611 |
| WM-115 | Vemurafenib | Defactinib | 0.000 | 0.000 | uM | 72 | hr | 2 | 4436 | 277 | 0.9941 | 1.0000 | 0.0624 | 0.0611 |
| WM-115 | Vemurafenib | Defactinib | 0.000 | 0.000 | uM | 72 | hr | 3 | 4497 | 283 | 1.0073 | 1.0000 | 0.0629 | 0.0611 |
| WM-115 | Vemurafenib | Defactinib | 0.000 | 0.316 | uM | 72 | hr | 1 | 3840 | 286 | 0.8495 | 0.8635 | 0.0745 | 0.0685 |
| WM-115 | Vemurafenib | Defactinib | 0.000 | 0.316 | uM | 72 | hr | 2 | 4089 | 304 | 0.9047 | 0.8635 | 0.0743 | 0.0685 |
| WM-115 | Vemurafenib | Defactinib | 0.000 | 0.316 | uM | 72 | hr | 3 | 3709 | 210 | 0.8363 | 0.8635 | 0.0566 | 0.0685 |
| WM-115 | Vemurafenib | Defactinib | 0.000 | 1.000 | uM | 72 | hr | 1 | 3214 | 215 | 0.7168 | 0.6669 | 0.0669 | 0.0743 |
| WM-115 | Vemurafenib | Defactinib | 0.000 | 1.000 | uM | 72 | hr | 2 | 2853 | 215 | 0.6305 | 0.6669 | 0.0754 | 0.0743 |
| WM-115 | Vemurafenib | Defactinib | 0.000 | 1.000 | uM | 72 | hr | 3 | 2973 | 240 | 0.6533 | 0.6669 | 0.0807 | 0.0743 |
| WM-115 | Vemurafenib | Defactinib | 0.000 | 3.160 | uM | 72 | hr | 1 | 2198 | 157 | 0.4878 | 0.4405 | 0.0714 | 0.0768 |
| WM-115 | Vemurafenib | Defactinib | 0.000 | 3.160 | uM | 72 | hr | 2 | 1877 | 148 | 0.4133 | 0.4405 | 0.0788 | 0.0768 |
| WM-115 | Vemurafenib | Defactinib | 0.000 | 3.160 | uM | 72 | hr | 3 | 1912 | 153 | 0.4204 | 0.4405 | 0.0800 | 0.0768 |
| WM-115 | Vemurafenib | Defactinib | 0.100 | 0.000 | uM | 72 | hr | 1 | 3619 | 242 | 0.8072 | 0.8216 | 0.0669 | 0.0659 |
| WM-115 | Vemurafenib | Defactinib | 0.100 | 0.000 | uM | 72 | hr | 2 | 3771 | 250 | 0.8416 | 0.8216 | 0.0663 | 0.0659 |
| WM-115 | Vemurafenib | Defactinib | 0.100 | 0.000 | uM | 72 | hr | 3 | 3649 | 235 | 0.8160 | 0.8216 | 0.0644 | 0.0659 |