Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-549 | TNBC | Basal B | Ribavirin | 15386.211 | uM | inf | 59.85870 | 0.8625 | 0.5247 | 4.9984 | -0.0100 | 0.6381 | 2.2025 | |||
| HCC2185 | TNBC | Luminal | PS-1145 | IKK | NFKB | 7464.065 | uM | inf | inf | 0.9611 | 0.9611 | 0.0000 | -0.0098 | -0.0695 | 0.7107 | |
| MDA-MB-231 | TNBC | Basal B | AG1478 | EGFR | ErbB | 7893.016 | uM | inf | inf | 1.0032 | 1.0032 | 0.0000 | -0.0097 | -0.1970 | 2.2064 | |
| MCF 10A | NM | Basal B | PS-1145 | IKK | NFKB | 7485.065 | uM | inf | inf | 1.0111 | 1.0111 | 0.0000 | -0.0094 | -0.0465 | 3.5869 | |
| SUM229PE | TNBC | - | Ribavirin | 15359.211 | uM | inf | inf | 0.9761 | 0.9761 | 0.0000 | -0.0092 | -0.0004 | 1.4356 | |||
| MDA-MB-231 | TNBC | Basal B | AG1478 | EGFR | ErbB | 7892.016 | uM | inf | inf | 0.9839 | 0.9839 | 0.0000 | -0.0090 | -0.1042 | 2.3475 | |
| HCC70 | TNBC | Basal A | PS-1145 | IKK | NFKB | 7470.065 | uM | inf | 997.07810 | 0.8477 | 0.8264 | 3.0748 | -0.0089 | 0.6820 | 1.0127 | |
| MCF12A | NM | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 10061.049 | uM | inf | 651.48010 | 0.8972 | 0.5117 | 4.9986 | -0.0089 | 0.6029 | 1.7845 | |
| CAL-85-1 | TNBC | - | Ribavirin | 15280.211 | uM | 104.41110 | 45.7480 | 0.6941 | 0.4856 | 4.2943 | -0.0088 | 0.8805 | 0.8608 | |||
| Hs 578T | TNBC | Basal B | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 7475.084 | uM | inf | 228.94580 | 0.7420 | 0.7418 | 4.9998 | -0.0088 | 0.8449 | 2.7804 | |
| 184A1 | NM | Basal | PS-1145 | IKK | NFKB | 5894.065 | uM | inf | 416.61250 | 0.8384 | 0.8383 | 4.9997 | -0.0087 | 0.7490 | 1.6064 | |
| HCC1428 | HR+ | Luminal | Trastuzumab | HER2 | ErbB | 7441.102 | uM | inf | inf | 0.9313 | 0.9313 | 0.0000 | -0.0087 | 0.3093 | 0.9144 | |
| MDA-MB-175-VII | HR+ | Luminal | Cetuximab | EGFR | ErbB | 7886.042 | uM | inf | inf | 0.9528 | 0.9528 | 0.0000 | -0.0085 | 0.3806 | 0.6462 | |
| Hs 578T | TNBC | Basal B | FTase Inhibitor I | Ftase | MAPK | 10694.154 | uM | inf | inf | 0.9764 | 0.9764 | 0.0000 | -0.0084 | -0.0364 | 2.3045 | |
| SUM1315MO2 | TNBC | Basal B | PS-1145 | IKK | NFKB | 10381.065 | uM | inf | inf | 0.8948 | 0.8948 | 0.0000 | -0.0084 | 0.4505 | 1.2390 | |
| BT-549 | TNBC | Basal B | PS-1145 | IKK | NFKB | 5910.065 | uM | inf | 476.28530 | 0.8804 | 0.8802 | 4.7010 | -0.0083 | 0.6645 | 3.2016 | |
| HCC1569 | HER2amp | Basal A | SB-3CT | MMP2/9 | MMP | 12523.168 | uM | inf | inf | 1.0409 | 1.0409 | 0.0000 | -0.0083 | -0.040 | 0.9035 | |
| MDA-MB-231 | TNBC | Basal B | (Z)-4-Hydroxytamoxifen | ESR1 | 7893.016 | uM | inf | 19.83710 | 0.9104 | 0.9100 | 4.9988 | -0.0081 | 0.6344 | 2.2064 | ||
| Hs 578T | TNBC | Basal B | Lapatinib | EGFR/HER2 | ErbB | 7474.098 | uM | inf | inf | 1.0223 | 1.0223 | 0.0000 | -0.0080 | -0.0536 | 2.6093 | |
| MB 157 | Unknown | Unknown | TCS PIM-1 1 | Pim kinase | PIM | 12580.135 | uM | inf | 150.77040 | 0.8333 | 0.5221 | 4.9812 | -0.0078 | 0.7813 | 2.1782 | |
| Hs 578T | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7864.042 | uM | inf | inf | 0.9446 | 0.9446 | 0.0000 | -0.0078 | -0.0792 | 1.4812 | |
| MCF7 | HR+ | Luminal | AG1024 | IGF1R | RTK | 7493.066 | uM | inf | inf | 0.9557 | 0.9557 | 0.0000 | -0.0077 | 0.2568 | 1.3293 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 5902.084 | uM | inf | inf | 0.9945 | 0.9945 | 0.0000 | -0.0077 | -0.0317 | 1.3532 | |
| BT-549 | TNBC | Basal B | Cetuximab | EGFR | ErbB | 7804.042 | uM | inf | 1.1360 | 0.9560 | 0.7915 | 2.6263 | -0.0076 | 0.5868 | 2.4955 | |
| MDA-MB-231 | TNBC | Basal B | CPT-11 | TOP1 | TOP | 7893.007 | uM | 161.04830 | 99.26170 | 0.7132 | 0.2620 | 1.5337 | -0.0075 | 0.8574 | 2.2909 |