Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| CAMA-1 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5911.094 | uM | 0.25033 | 0.05775 | 0.4743 | 0.4915 | 2.7768 | 0.4432 | 0.8140 | 1.0146 | |
| HCC1395 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7435.095 | uM | inf | inf | 0.8669 | 0.8669 | 0.0000 | 0.0762 | -0.0489 | 0.8762 | |
| BT-474 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5905.095 | uM | inf | inf | 0.9541 | 0.9541 | 0.0000 | 0.0237 | 0.0563 | 0.9590 | |
| CAMA-1 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5912.095 | uM | inf | inf | 0.7782 | 0.7782 | 0.0000 | 0.1986 | 0.5533 | 0.9981 | |
| HCC1187 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7432.095 | uM | inf | inf | 1.0222 | 1.0222 | 0.0000 | 0.0161 | 0.1254 | 0.8368 | |
| HCC1187 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7431.095 | uM | inf | inf | 0.5824 | 0.5824 | 0.0000 | 0.2553 | 0.5276 | 1.2776 | |
| AU565 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5900.095 | uM | inf | 0.31780 | 0.6870 | 0.6767 | 1.2492 | 0.2241 | 0.9272 | 2.1880 | |
| BT-474 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5906.095 | uM | inf | inf | 1.0129 | 1.0129 | 0.0000 | 0.0481 | 0.0000 | 0.6731 | |
| BT-549 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5910.095 | uM | inf | inf | 0.9453 | 0.9453 | 0.0000 | 0.0098 | 0.4927 | 3.2727 | |
| BT-549 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5909.095 | uM | inf | 21.08430 | 0.9127 | 0.9359 | 5.0000 | 0.0085 | 0.6083 | 2.7716 | |
| HCC1143 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7430.095 | uM | inf | inf | 0.8459 | 0.8459 | 0.0000 | 0.1262 | 0.4872 | 1.9390 | |
| HCC1187 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7433.095 | uM | inf | inf | 0.2099 | 0.2099 | 0.0000 | 0.6689 | 0.1148 | 0.9260 | |
| BT-20 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5904.095 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.6537 | |
| BT-20 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5902.095 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 1.0245 | |
| 600MPE | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5898.095 | uM | inf | inf | 0.3076 | 0.3076 | 0.0000 | 0.6877 | 0.0000 | 0.6975 | |
| 184B5 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5896.095 | uM | 0.24202 | 0.32119 | -0.2838 | -0.2743 | 1.5454 | 0.9106 | 0.9931 | 1.5532 | |
| 600MPE | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5899.094 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0167 | -0.1754 | 1.0334 | |
| BT-20 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 10385.095 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0010 | 0.0617 | 0.7986 | |
| AU565 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5901.095 | uM | inf | 0.0510 | 0.5951 | 0.6004 | 0.9976 | 0.3405 | 0.8985 | 1.9104 | |
| BT-483 | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5908.095 | uM | inf | inf | 0.4981 | 0.4981 | 0.0000 | 0.4703 | 0.3268 | 0.5012 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5895.095 | uM | 0.40767 | 0.41810 | -0.0165 | -0.0219 | 1.6956 | 0.7104 | 0.9924 | 1.4629 | |
| 184A1 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5894.095 | uM | 53.72510 | 62.72890 | -0.1792 | -0.0920 | 1.0901 | 0.3508 | 0.940 | 1.7133 | |
| 184B5 | NM | Basal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5897.095 | uM | 0.52125 | 0.66097 | -0.3237 | -0.3105 | 2.0341 | 0.8593 | 0.9969 | 1.2197 | |
| HCC1419 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7437.095 | uM | inf | inf | 0.9403 | 0.9403 | 0.0000 | 0.1007 | -0.0689 | 0.5584 | |
| HCC1395 | TNBC | Basal B | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 7436.095 | uM | inf | inf | 0.9643 | 0.9643 | 0.0000 | 0.0131 | 0.0000 | 1.3597 |