Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | Cisplatin | DNA cross-linker | DNA cross-linker | 9254.049 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.8730 | |
| HCC1187 | TNBC | Basal A | PD184352 | MEK | MAPK | 7812.029 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0727 | 0.0526 | 0.9642 | |
| HCC1187 | TNBC | Basal A | PD184352 | MEK | MAPK | 7812.029 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0727 | 0.0526 | 0.9642 | |
| CAMA-1 | HR+ | Luminal | Ribavirin | 15348.211 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0410 | -5.7835 | 0.7490 | |||
| EFM-192B | HER2amp | Luminal | Ribavirin | 15387.211 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0048 | -0.0190 | 1.2404 | |||
| HCC1187 | TNBC | Basal A | LY294002 | PI3K | PI3K | 7812.029 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0475 | -56.7271 | 0.9642 | |
| BT-483 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 9186.026 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.5108 | |
| BT-474 | HER2amp | Luminal | PS-1145 | IKK | NFKB | 5905.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0377 | -5.6704 | 0.8461 | |
| BT-483 | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9186.049 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0318 | -0.9738 | 0.6923 | |
| CAMA-1 | HR+ | Luminal | Cetuximab | EGFR | ErbB | 7805.018 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0217 | -0.4906 | 1.1451 | |
| EFM-192B | HER2amp | Luminal | Ribavirin | 15288.211 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0002 | -0.0013 | 0.9250 | |||
| 600MPE | HR+ | Luminal | AG1024 | IGF1R | RTK | 5899.066 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0165 | 0.0780 | 0.7056 | |
| 600MPE | HR+ | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5899.094 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0167 | -0.1754 | 1.0334 | |
| BT-20 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5902.095 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 1.0245 | |
| BT-20 | TNBC | Basal A | Trastuzumab | HER2 | ErbB | 5903.102 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0171 | -0.1575 | 1.2557 | |
| BT-20 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5904.095 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 0.6537 | |
| BT-20 | TNBC | Basal A | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 10385.095 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0010 | 0.0617 | 0.7986 | |
| BT-474 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 12178.145 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0369 | 0.0948 | 0.6127 | |
| AU565 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 10880.155 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0108 | -0.1312 | 1.5205 | |
| BT-20 | TNBC | Basal A | Methotrexate | DHFR | Metabolism | 5904.085 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0334 | -1.4110 | 1.2247 | |
| BT-474 | HER2amp | Luminal | PS-1145 | IKK | NFKB | 5906.065 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0021 | -0.0022 | 0.6586 | |
| BT-549 | TNBC | Basal B | GW-5074 | CRAF | MAPK | 5909.088 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0255 | -2.9579 | 2.9659 | |
| AU565 | HER2amp | Luminal | Cetuximab | EGFR | ErbB | 7794.018 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0500 | -inf | 1.6812 | |
| HCC1419 | HER2amp | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 10019.049 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0250 | -0.1954 | 0.4626 | |
| HCC1395 | TNBC | Basal B | Nilotinib | ABL | nRTK | 12000.145 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0614 | 0.0000 | 0.6084 |