Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR75B | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9972.011 | uM | 291.84250 | 470.96030 | -0.6718 | -0.8574 | 2.0869 | 0.1284 | 0.9943 | 0.9432 | |
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 9972.121 | uM | 1.14060 | 0.77283 | 0.2080 | 0.2463 | 1.7425 | 0.2684 | 0.9929 | 1.1034 | |
| ZR75B | HR+ | Luminal | AG1024 | IGF1R | RTK | 7555.066 | uM | inf | inf | 0.9180 | 0.9180 | 0.0000 | 0.0229 | 0.320 | 1.7081 | |
| ZR75B | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9997.011 | uM | 392.17980 | 716.46410 | -0.5311 | -1.0000 | 1.8231 | 0.1305 | 0.9710 | 1.0551 | |
| ZR75B | HR+ | Luminal | CGC-11047 | Polyamine analogue | 9972.125 | uM | 62.05340 | 1000.00000 | -0.5139 | -0.9610 | 0.3858 | 0.3920 | 0.8676 | 1.1854 | ||
| ZR75B | HR+ | Luminal | CPT-11 | TOP1 | TOP | 9997.121 | uM | 1.66170 | 0.86071 | 0.2842 | 0.3340 | 1.6759 | 0.2165 | 0.9826 | 1.1121 | |
| ZR75B | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 9997.037 | uM | 0.11058 | 0.20364 | -0.4591 | -0.2188 | 0.5944 | 0.5503 | 0.9139 | 1.2339 | |
| ZR75B | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 11939.158 | uM | 3.02660 | 4.45570 | -0.8910 | -0.9000 | 2.6622 | 0.4909 | 0.9719 | 1.7251 | |
| ZR75B | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 7555.073 | uM | 62.88950 | 38.68310 | 0.3348 | 0.2333 | 1.2931 | 0.1098 | 0.9813 | 1.6372 | |
| ZR75B | HR+ | Luminal | Bosutinib | Src | nRTK | 11939.145 | uM | 6.84850 | 6.78980 | 0.0290 | 0.0078 | 1.8231 | 0.2582 | 0.9605 | 1.6830 | |
| ZR75B | HR+ | Luminal | Cetuximab | EGFR | ErbB | 9972.125 | uM | 4.30080 | 14.18760 | 0.8594 | -0.8482 | 0.8310 | 0.0135 | 0.6892 | 1.1854 | |
| ZR75B | HR+ | Luminal | CGC-11047 | Polyamine analogue | 9997.026 | uM | 694.32460 | 1000.00000 | -0.6676 | -0.5458 | 2.0226 | 0.2645 | 0.8363 | 1.1348 | ||
| ZR75B | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9997.049 | uM | inf | inf | 0.9585 | 0.9585 | 0.0000 | 0.0082 | 0.0001 | 1.1423 | |
| ZR75B | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9972.017 | uM | 15.96770 | 42.6540 | -0.7631 | -1.0000 | 1.1181 | 0.2804 | 0.9966 | 1.1666 | |
| ZR75B | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 9972.019 | uM | 16.51190 | 102.41180 | -0.1602 | -1.0000 | 0.6020 | 0.2248 | 0.9936 | 1.0654 | ||
| ZR75B | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 9972.037 | uM | 0.02505 | 0.0480 | -0.7246 | -0.3436 | 0.8045 | 0.7513 | 0.9126 | 1.0789 | |
| ZR75B | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 11939.143 | uM | 9.44420 | 7.37240 | 0.0351 | 0.0799 | 0.7026 | 0.4587 | 0.9862 | 1.7414 | |
| ZR75B | HR+ | Luminal | 5-FU | TYMS | TYMS | 9972.017 | uM | 6.61280 | 415.5050 | -0.5105 | -1.0000 | 0.2653 | 0.7315 | 0.8568 | 1.1666 | |
| ZR75B | HR+ | Luminal | AG1478 | EGFR | ErbB | 9972.019 | uM | inf | 0.33269 | 0.7757 | 0.8429 | 1.0683 | 0.0605 | 0.6908 | 1.0654 | |
| ZR75B | HR+ | Luminal | AS-252424 | PI3K | PI3K | 11939.158 | uM | 53.8080 | 104.91790 | 0.4603 | -0.0864 | 0.2386 | 0.2202 | 0.8121 | 1.7251 | |
| ZR75B | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 7555.074 | uM | 0.16362 | 0.33589 | -0.4568 | -0.4040 | 0.8234 | 0.6783 | 0.9802 | 1.6682 | |
| ZR75B | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 7555.074 | uM | 0.16362 | 0.33589 | -0.4568 | -0.4040 | 0.8234 | 0.6783 | 0.9802 | 1.6682 | |
| ZR75B | HR+ | Luminal | Cetuximab | EGFR | ErbB | 9997.026 | uM | inf | inf | 0.9578 | 0.9578 | 0.0000 | -0.0328 | -0.7332 | 1.1348 | |
| ZR75B | HR+ | Luminal | Dichloroacetate | PDK | PDK | 13595.176 | uM | inf | inf | 0.8559 | 0.8559 | 0.0000 | 0.0398 | 0.3144 | 1.9155 | |
| ZR75B | HR+ | Luminal | Dactolisib | PI3K | PI3K | 11939.155 | uM | 0.12564 | 0.09671 | 0.2549 | 0.2262 | 2.3010 | 0.3973 | 0.7606 | 1.6625 |