Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 600MPE | HR+ | Luminal | FTase Inhibitor I | Ftase | MAPK | 12224.154 | uM | inf | inf | 0.7982 | 0.7982 | 0.0000 | 0.0654 | 0.1825 | 0.9590 | |
| 600MPE | HR+ | Luminal | Gefitinib | EGFR | ErbB | 7791.016 | uM | 3.52850 | 16.87850 | -0.3145 | -1.0000 | 0.7019 | 0.1980 | 0.9546 | 0.8138 | |
| 600MPE | HR+ | Luminal | Gefitinib | EGFR | ErbB | 9118.019 | uM | 10.95370 | 30.54190 | -0.0690 | -1.0000 | 1.0714 | 0.1294 | 0.9557 | 1.0707 | |
| 600MPE | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 9118.012 | uM | 0.02890 | 0.02905 | -0.0735 | -0.0123 | 4.8863 | 0.6302 | 0.9909 | 1.0154 | |
| 600MPE | HR+ | Luminal | Geldanamycin | HSP90 | HSP90 | 9120.012 | uM | 0.04341 | 0.05163 | -0.2968 | -0.2135 | 2.0507 | 0.6917 | 0.9943 | 0.6867 | |
| 600MPE | HR+ | Luminal | Gemcitabine | DNA replication | DNA replication | 9118.011 | uM | 0.02406 | 0.01538 | 0.1359 | 0.2114 | 1.2273 | 0.5462 | 0.9664 | 1.0538 | |
| 600MPE | HR+ | Luminal | Glycyl-H-1152 | ROCK2 | 12224.16 | uM | inf | inf | 0.9729 | 0.9729 | 0.0000 | 0.0688 | 0.1842 | 0.7734 | ||
| 600MPE | HR+ | Luminal | GM6001 | MMP | MMP | 5898.096 | uM | inf | inf | 0.8794 | 0.8794 | 0.0000 | 0.0460 | -0.0341 | 0.6718 | |
| 600MPE | HR+ | Luminal | GSK1070916 | AURK | AURK | 9118.001 | uM | 8.85750 | 10.72720 | -0.7457 | -0.7533 | 4.7981 | 0.1096 | 0.9927 | 1.0946 | |
| 600MPE | HR+ | Luminal | GSK1070916 | AURK | AURK | 9120.001 | uM | 8.03260 | 10.00750 | -0.9954 | -0.9997 | 4.9967 | 0.1399 | 0.9964 | 0.6180 | |
| 600MPE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 5898.091 | uM | 0.32342 | 1.23240 | -0.9978 | -1.0000 | 0.8212 | 0.7254 | 0.9476 | 0.6159 | |
| 600MPE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 5899.098 | uM | 0.26223 | 1.66230 | -0.8751 | -1.0000 | 0.5949 | 0.6216 | 0.9891 | 1.1012 | |
| 600MPE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 5899.09 | uM | 0.45454 | 0.39719 | 0.1073 | 0.1332 | 2.2958 | 0.4063 | 0.9921 | 1.0401 | |
| 600MPE | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 5899.07 | uM | 0.22856 | 0.81326 | -0.9610 | -1.0000 | 0.8656 | 0.6820 | 0.9966 | 0.8850 | |
| 600MPE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 9118.001 | uM | 10.85090 | 4.85940 | 0.4914 | 0.4910 | 4.9999 | 0.1089 | 0.7439 | 1.0946 | |
| 600MPE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 9120.001 | uM | 10.38820 | 12.94090 | -0.9973 | -1.0000 | 5.0000 | 0.2756 | 0.7682 | 0.6180 | |
| 600MPE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 9120.001 | uM | inf | inf | 0.4795 | 0.4795 | 0.0000 | 0.1244 | 0.2915 | 0.6180 | |
| 600MPE | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 9118.001 | uM | inf | inf | 0.5960 | 0.5960 | 0.0000 | 0.1146 | 0.4985 | 1.0946 | |
| 600MPE | HR+ | Luminal | GW-5074 | CRAF | MAPK | 5898.088 | uM | inf | inf | 0.8157 | 0.8157 | 0.0000 | 0.0414 | -0.0040 | 0.6095 | |
| 600MPE | HR+ | Luminal | Ibandronate | FDPS | 12224.143 | uM | 126.68820 | 145.52130 | -0.4151 | -0.4152 | 4.3619 | 0.2882 | 0.9949 | 0.8349 | ||
| 600MPE | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 12224.157 | uM | inf | inf | 0.6710 | 0.6710 | 0.0000 | 0.1152 | 0.3373 | 1.0737 | |
| 600MPE | HR+ | Luminal | IKK16 | IKK | NFKB | 5898.093 | uM | 4.19220 | 5.22240 | -0.9978 | -1.0000 | 5.0000 | 0.4738 | 0.9724 | 0.6963 | |
| 600MPE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 5898.091 | uM | 24.51260 | 30.53630 | -0.9995 | -1.0000 | 4.9997 | 0.4350 | 0.9907 | 0.6159 | |
| 600MPE | HR+ | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 5899.09 | uM | 24.01090 | 30.41110 | -0.9860 | -0.9843 | 4.6046 | 0.4245 | 0.9976 | 1.0401 | |
| 600MPE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 5898.067 | uM | 0.01049 | 0.19206 | -0.9986 | -1.0000 | 0.3778 | 0.8076 | 0.8890 | 0.6532 |