Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 600MPE | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9118.011 | uM | 106.49180 | 150.93380 | -0.5458 | -0.5615 | 2.1585 | 0.2813 | 0.9873 | 1.0538 | |
| 600MPE | HR+ | Luminal | Carboplatin | DNA cross-linker | DNA cross-linker | 9120.021 | uM | 167.71170 | 310.00060 | -0.8949 | -1.0000 | 1.7883 | 0.2223 | 0.9943 | 0.6486 | |
| 600MPE | HR+ | Luminal | Cetuximab | EGFR | ErbB | 9118.006 | uM | inf | inf | 0.8545 | 0.8545 | 0.0000 | 0.0747 | 0.3005 | 1.1089 | |
| 600MPE | HR+ | Luminal | Cetuximab | EGFR | ErbB | 7791.018 | uM | inf | inf | 0.8577 | 0.8577 | 0.0000 | -0.0332 | 0.4860 | 0.8558 | |
| 600MPE | HR+ | Luminal | CGC-11047 | Polyamine analogue | 9120.034 | uM | 577.71850 | 1000.00000 | -0.9938 | -0.8954 | 1.8706 | 0.3615 | 0.7952 | 0.5982 | ||
| 600MPE | HR+ | Luminal | CGC-11047 | Polyamine analogue | 9118.006 | uM | 19.38340 | 1000.00000 | -0.3482 | -0.8489 | 0.2517 | 0.4796 | 0.8081 | 1.1089 | ||
| 600MPE | HR+ | Luminal | CGC-11047 | Polyamine analogue | 7791.018 | uM | 37.21070 | 1000.00000 | -0.5335 | -0.9987 | 0.3335 | 0.4412 | 0.8303 | 0.8558 | ||
| 600MPE | HR+ | Luminal | Chloroquine | 13091.177 | uM | inf | inf | -1.0000 | -1.0000 | 0.0000 | 0.3682 | 0.5443 | 0.7004 | |||
| 600MPE | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9120.021 | uM | 44.1310 | 54.28280 | -0.9070 | -0.9079 | 5.0000 | 0.2126 | 0.9946 | 0.6486 | |
| 600MPE | HR+ | Luminal | Cisplatin | DNA cross-linker | DNA cross-linker | 9118.017 | uM | 13.86890 | 18.80040 | -0.5620 | -0.5659 | 2.4880 | 0.3108 | 0.9957 | 1.0401 | |
| 600MPE | HR+ | Luminal | CPT-11 | TOP1 | TOP | 9120.034 | uM | 23.46960 | 28.04160 | -0.0787 | -0.2234 | 2.0753 | 0.0669 | 0.9866 | 0.5982 | |
| 600MPE | HR+ | Luminal | Dactolisib | PI3K | PI3K | 12224.155 | uM | inf | inf | 0.7744 | 0.7744 | 0.0000 | 0.1982 | 0.2284 | 1.0378 | |
| 600MPE | HR+ | Luminal | Dichloroacetate | PDK | PDK | 13091.176 | uM | inf | inf | 0.9717 | 0.9717 | 0.0000 | 0.0439 | -0.10 | 0.8746 | |
| 600MPE | HR+ | Luminal | Disulfiram | Proteasome | Proteasome | 13091.174 | uM | 0.14887 | 0.16877 | -0.5761 | -0.4361 | 5.0000 | 0.6871 | 0.9453 | 0.7967 | |
| 600MPE | HR+ | Luminal | Docetaxel | TUBB | TUBB | 9118.002 | uM | 0.07538 | 0.02079 | 0.4055 | 0.4778 | 2.4163 | 0.2572 | 0.8857 | 0.9880 | |
| 600MPE | HR+ | Luminal | Doxorubicin | TOP2 | TOP | 9120.034 | uM | 0.5260 | 0.78248 | -0.9981 | -0.7368 | 2.2803 | 0.6096 | 0.9751 | 0.5982 | |
| 600MPE | HR+ | Luminal | Epirubicin | TOP2 | TOP | 9118.017 | uM | 0.31034 | 0.33301 | -0.1712 | -0.2113 | 5.0000 | 0.5870 | 0.9550 | 1.0401 | |
| 600MPE | HR+ | Luminal | Erlotinib | EGFR | ErbB | 5898.091 | uM | 20.1330 | 0.24083 | 0.4251 | 0.3963 | 0.3555 | 0.2818 | 0.8367 | 0.6159 | |
| 600MPE | HR+ | Luminal | Erlotinib | EGFR | ErbB | 5899.09 | uM | 38.92280 | 999.98590 | 0.4189 | -0.8505 | 0.3061 | 0.1622 | 0.9366 | 1.0401 | |
| 600MPE | HR+ | Luminal | Etoposide | TOP2 | TOP | 5899.074 | uM | 1.14810 | 2.63790 | -0.2761 | -0.3486 | 0.6359 | 0.5313 | 0.9578 | 0.8860 | |
| 600MPE | HR+ | Luminal | Etoposide | TOP2 | TOP | 5898.074 | uM | 15.02450 | 20.60720 | -0.1933 | -0.2481 | 1.2753 | 0.3097 | 0.9810 | 0.7134 | |
| 600MPE | HR+ | Luminal | Everolimus | MTOR | MTOR | 12224.164 | uM | 17.00210 | 145.43470 | 0.1428 | -1.0000 | 0.5118 | 0.1695 | 0.9433 | 0.8454 | |
| 600MPE | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 5898.085 | uM | 0.26595 | 0.36220 | -0.9980 | -1.0000 | 3.5567 | 0.7703 | 0.9784 | 0.7048 | |
| 600MPE | HR+ | Luminal | Fascaplysin | CDK4 | CDK | 5899.084 | uM | 0.31115 | 0.39093 | -0.9766 | -0.9765 | 4.7442 | 0.6654 | 0.9990 | 1.1144 | |
| 600MPE | HR+ | Luminal | FR180204 | ERK1/2 | MAPK | 12224.161 | uM | 22.8940 | 25.34580 | -0.3232 | -0.3247 | 4.9183 | 0.1696 | 0.9495 | 0.7139 |