Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 21NT | HER2amp | - | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14194.189 | uM | 0.27941 | 0.47801 | -0.6718 | -0.7185 | 1.6590 | 0.6888 | 0.9927 | 2.3616 | |
| 21NT | HER2amp | - | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14610.189 | uM | 0.28136 | 0.47547 | -0.9402 | -0.9548 | 2.0356 | 0.7876 | 0.9958 | 1.0787 | |
| 21PT | HER2amp | - | Bortezomib | Proteasome | Proteasome | 14715.203 | uM | 0.01691 | 0.02685 | -0.7771 | -0.7768 | 2.0279 | 1.0962 | 0.9968 | 2.0168 | |
| 21PT | HER2amp | - | Bortezomib | Proteasome | Proteasome | 14715.203 | uM | 0.01691 | 0.02685 | -0.7771 | -0.7768 | 2.0279 | 1.0962 | 0.9968 | 2.0168 | |
| 600MPE | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 7791.016 | uM | 30.5560 | 28.8140 | 0.1274 | 0.1272 | 4.9999 | 0.0881 | 0.9826 | 0.8138 | ||
| 600MPE | HR+ | Luminal | (Z)-4-Hydroxytamoxifen | ESR1 | 9118.019 | uM | 70.89780 | 103.69460 | -0.5926 | -0.9958 | 2.8821 | 0.0861 | 0.9929 | 1.0707 | ||
| 600MPE | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 7791.05 | uM | 0.19521 | 5.16170 | -0.6281 | -0.9627 | 0.3278 | 0.5521 | 0.8525 | 0.7929 | |
| 600MPE | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 9118.037 | uM | 0.04887 | 0.06801 | -0.6590 | -0.2633 | 1.2803 | 0.6962 | 0.9129 | 1.0733 | |
| 600MPE | HR+ | Luminal | 2-deoxyglucose | 13091.177 | uM | inf | inf | 0.9504 | 0.9504 | 0.0000 | 0.3143 | 0.0580 | 0.7004 | |||
| 600MPE | HR+ | Luminal | 5-DFUR | TYMS | TYMS | 12224.143 | uM | 0.98003 | 1.61660 | -0.3636 | -0.1428 | 0.5018 | 0.6782 | 0.9151 | 0.8349 | |
| 600MPE | HR+ | Luminal | 5-FU | TYMS | TYMS | 9118.017 | uM | 78.35630 | 305.35030 | -0.9327 | -1.0000 | 0.8077 | 0.6926 | 0.9801 | 1.0401 | |
| 600MPE | HR+ | Luminal | Afatinib | EGFR/HER2 | ErbB | 12224.165 | uM | 2.4860 | 3.88950 | -0.9804 | -1.0000 | 2.4546 | 0.6104 | 0.9030 | 0.9714 | |
| 600MPE | HR+ | Luminal | AG1024 | IGF1R | RTK | 5898.066 | uM | inf | inf | 1.0423 | 1.0423 | 0.0000 | 0.0282 | 0.0610 | 0.6097 | |
| 600MPE | HR+ | Luminal | AG1024 | IGF1R | RTK | 5899.066 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | 0.0165 | 0.0780 | 0.7056 | |
| 600MPE | HR+ | Luminal | AG1478 | EGFR | ErbB | 9118.019 | uM | inf | 1.05170 | 0.7726 | 0.8575 | 5.0000 | 0.0428 | 0.5984 | 1.0707 | |
| 600MPE | HR+ | Luminal | AG1478 | EGFR | ErbB | 7791.016 | uM | 34.63250 | 70.58790 | -0.6402 | -1.0000 | 1.5428 | 0.2456 | 0.8929 | 0.8138 | |
| 600MPE | HR+ | Luminal | AS-252424 | PI3K | PI3K | 12224.165 | uM | 8.75170 | 136.14630 | 0.2719 | -1.0000 | 0.4003 | 0.2034 | 0.8983 | 0.9714 | |
| 600MPE | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 12224.072 | uM | inf | inf | 0.8349 | 0.8349 | 0.0000 | 0.1299 | -0.0188 | 1.0105 | |
| 600MPE | HR+ | Luminal | Baicalein | Lipoxygenase | Metabolism | 5898.073 | uM | 76.61160 | 42.69180 | 0.4721 | 0.4715 | 4.8965 | 0.0929 | 0.7095 | 0.6501 | |
| 600MPE | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 5898.074 | uM | 1.85990 | 6.61990 | -0.8905 | -1.0000 | 0.8654 | 0.5349 | 0.9882 | 0.7134 | |
| 600MPE | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 5898.074 | uM | 1.85990 | 6.61990 | -0.8905 | -1.0000 | 0.8654 | 0.5349 | 0.9882 | 0.7134 | |
| 600MPE | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 5899.074 | uM | 0.17688 | 0.27882 | -0.9849 | -0.9707 | 2.3705 | 0.9998 | 0.9959 | 0.8860 | |
| 600MPE | HR+ | Luminal | Bortezomib | Proteasome | Proteasome | 5899.074 | uM | 0.17688 | 0.27882 | -0.9849 | -0.9707 | 2.3705 | 0.9998 | 0.9959 | 0.8860 | |
| 600MPE | HR+ | Luminal | Bosutinib | Src | nRTK | 12224.145 | uM | 6.17790 | 4.29030 | 0.3962 | 0.4192 | 5.0000 | 0.1266 | 0.9757 | 0.9737 | |
| 600MPE | HR+ | Luminal | Bromopyruvic acid | Hexokinase II | Metabolism | 13091.177 | uM | 0.13548 | 0.2280 | -1.0000 | -1.0000 | 2.1106 | 0.8509 | 0.9450 | 0.7004 |