Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | MG-132 | Proteasome | Proteasome | 14113.189 | uM | 0.18071 | 0.20019 | -0.8904 | -0.3341 | 4.9988 | 0.6752 | 0.6217 | 1.4645 | |
| AU565 | HER2amp | Luminal | MG-132 | Proteasome | Proteasome | 14613.189 | uM | 0.20844 | 0.28381 | -0.8251 | -0.8011 | 3.0985 | 0.7965 | 0.9967 | 1.5791 | |
| AU565 | HER2amp | Luminal | MG-132 | Proteasome | Proteasome | 14613.189 | uM | 0.20844 | 0.28381 | -0.8251 | -0.8011 | 3.0985 | 0.7965 | 0.9967 | 1.5791 | |
| AU565 | HER2amp | Luminal | MG-132 | Proteasome | Proteasome | 10880.145 | uM | 0.09891 | 0.14835 | -0.8600 | -0.8655 | 2.4784 | 0.8973 | 0.9987 | 1.4751 | |
| AU565 | HER2amp | Luminal | MG-132 | Proteasome | Proteasome | 10880.145 | uM | 0.09891 | 0.14835 | -0.8600 | -0.8655 | 2.4784 | 0.8973 | 0.9987 | 1.4751 | |
| AU565 | HER2amp | Luminal | Pevonedistat | NAE1 | NAE1 | 10880.148 | uM | 0.17244 | 0.19441 | -0.1883 | -0.1624 | 2.3455 | 0.5346 | 0.9988 | 1.7293 | |
| AU565 | HER2amp | Luminal | Nelfinavir | 13030.174 | uM | inf | inf | 0.9367 | 0.9367 | 0.0000 | 0.0424 | 0.0713 | 0.8615 | |||
| AU565 | HER2amp | Luminal | Nilotinib | ABL | nRTK | 10880.145 | uM | inf | inf | 0.9804 | 0.9804 | 0.0000 | 0.0621 | 0.0247 | 1.4751 | |
| AU565 | HER2amp | Luminal | NSC 663284 | CDC25 | CDC | 10880.152 | uM | 1.58810 | 2.95150 | -0.9114 | -0.9095 | 1.6722 | 0.5940 | 0.9992 | 1.5019 | |
| AU565 | HER2amp | Luminal | NU6102 | CDK1/2 | CDK | 10880.147 | uM | 20.07910 | 29.68650 | -0.8151 | -1.0000 | 2.8097 | 0.1900 | 0.9822 | 1.5262 | |
| AU565 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 5901.066 | uM | 17.49280 | 19.24160 | -0.2302 | -0.2377 | 4.0825 | 0.1127 | 0.9933 | 1.9445 | |
| AU565 | HER2amp | Luminal | Nutlin 3a | MDM2 | MDM2 | 5900.066 | uM | 24.91350 | 21.33040 | 0.2504 | 0.2452 | 4.3416 | 0.0573 | 0.9955 | 2.7232 | |
| AU565 | HER2amp | Luminal | Olomoucine II | CDK1 | CDK | 10880.147 | uM | 4.03110 | 5.4510 | -0.8894 | -0.8679 | 3.3352 | 0.4700 | 0.9948 | 1.5262 | |
| AU565 | HER2amp | Luminal | Omipalisib | PI3K | PI3K | 5900.086 | uM | 0.01536 | 0.01535 | -0.0499 | 0.0002 | 0.5740 | 0.5816 | 0.9732 | 2.1682 | |
| AU565 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 9146.12 | uM | 2.20640 | 6.19270 | -0.9837 | -1.0000 | 1.0645 | 0.7511 | 0.9901 | 1.1135 | |
| AU565 | HER2amp | Luminal | Oxaliplatin | DNA cross-linker | DNA cross-linker | 7793.011 | uM | 3.55610 | 8.87250 | -0.9724 | -0.9948 | 1.1978 | 0.6742 | 0.9910 | 1.1456 | |
| AU565 | HER2amp | Luminal | Oxamflatin | HDAC | HDAC | 10880.147 | uM | 0.66311 | 1.12120 | -0.9051 | -0.8879 | 1.9438 | 0.6161 | 0.9958 | 1.5262 | |
| AU565 | HER2amp | Luminal | PD 98059 | MEK | MAPK | 10880.152 | uM | 9.51460 | 9.97780 | 0.2230 | -0.0179 | 0.7412 | 0.1723 | 0.9843 | 1.5019 | |
| AU565 | HER2amp | Luminal | PD173074 | FGFR1/3 | RTK | 5900.093 | uM | 7.81730 | 8.08240 | -0.0822 | -0.0837 | 4.6403 | 0.0867 | 0.9940 | 2.3084 | |
| AU565 | HER2amp | Luminal | PD184352 | MEK | MAPK | 10880.155 | uM | inf | inf | 0.9535 | 0.9535 | 0.0000 | 0.0209 | -0.0479 | 1.5205 | |
| AU565 | HER2amp | Luminal | PD184352 | MEK | MAPK | 10880.155 | uM | inf | inf | 0.9535 | 0.9535 | 0.0000 | 0.0209 | -0.0479 | 1.5205 | |
| AU565 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5901.095 | uM | inf | 0.0510 | 0.5951 | 0.6004 | 0.9976 | 0.3405 | 0.8985 | 1.9104 | |
| AU565 | HER2amp | Luminal | Pemetrexed | TYMS/DHFR/GARFT | TYMS | 5900.095 | uM | inf | 0.31780 | 0.6870 | 0.6767 | 1.2492 | 0.2241 | 0.9272 | 2.1880 | |
| AU565 | HER2amp | Luminal | PS-1145 | IKK | NFKB | 5901.065 | uM | inf | inf | 0.9807 | 0.9807 | 0.0000 | 0.0027 | -0.0002 | 2.0114 | |
| AU565 | HER2amp | Luminal | PS-1145 | IKK | NFKB | 5900.065 | uM | inf | inf | 0.9321 | 0.9321 | 0.0000 | -0.0050 | 0.3225 | 2.2026 |