Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 5900.067 | uM | inf | inf | 0.9793 | 0.9793 | 0.0000 | -0.0189 | -0.4227 | 2.4324 | |
| AU565 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 5901.067 | uM | inf | 7.55960 | 0.5017 | 0.5670 | 5.0000 | 0.1061 | 0.9459 | 1.8762 | |
| AU565 | HER2amp | Luminal | QNZ | NFkB | NFKB | 5900.096 | uM | inf | 0.13845 | 0.6010 | 0.5948 | 0.4531 | 0.1732 | 0.9514 | 2.7795 | |
| AU565 | HER2amp | Luminal | Ribavirin | 15384.211 | uM | inf | 16.10260 | 0.6064 | 0.6043 | 4.5946 | 0.0152 | 0.9411 | 1.3162 | |||
| AU565 | HER2amp | Luminal | SB-3CT | MMP2/9 | MMP | 10880.144 | uM | inf | inf | 0.6825 | 0.6825 | 0.0000 | 0.0829 | 0.4632 | 1.8532 | |
| AU565 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 10880.155 | uM | inf | inf | 1.0500 | 1.0500 | 0.0000 | -0.0108 | -0.1312 | 1.5205 | |
| AU565 | HER2amp | Luminal | Sigma A6730 | AKT | AKT | 10880.153 | uM | 2.73280 | 8.96010 | -0.8497 | -1.0000 | 0.9252 | 0.4067 | 0.9538 | 1.6896 | |
| AU565 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 9035.068 | uM | 0.02861 | 0.00785 | 0.2520 | 0.4349 | 1.5761 | 0.4265 | 0.8873 | 2.1391 | |
| AU565 | HER2amp | Luminal | Sirolimus | MTOR | MTOR | 5901.069 | uM | 0.11107 | 0.01528 | 0.3469 | 0.3967 | 0.7950 | 0.3507 | 0.9847 | 1.6847 | |
| AU565 | HER2amp | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5900.085 | uM | inf | inf | 0.5199 | 0.5199 | 0.0000 | 0.0667 | 0.2964 | 2.6391 | |
| AU565 | HER2amp | Luminal | Sorafenib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5901.084 | uM | 335.00020 | 221.35420 | 0.3042 | 0.2167 | 1.3710 | 0.0961 | 0.9889 | 1.7402 | |
| AU565 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5901.067 | uM | 4.63720 | 9.09190 | -0.9518 | -1.0000 | 1.6318 | 0.4670 | 0.9940 | 1.8762 | |
| AU565 | HER2amp | Luminal | Sunitinib | PDGFR/VEGFR/KIT/FLT3 | RTK | 5900.067 | uM | 5.14960 | 9.72040 | -0.8780 | -0.9134 | 1.6357 | 0.4184 | 0.9978 | 2.4324 | |
| AU565 | HER2amp | Luminal | TAPI-0 | TACE/Collagenase | 5900.096 | uM | inf | 110.82150 | 0.8488 | 0.6075 | 0.3356 | 0.0509 | 0.8117 | 2.7795 | ||
| AU565 | HER2amp | Luminal | Taxol | TUBB | TUBB | 9146.002 | uM | 0.00837 | 0.00997 | -0.7227 | -0.6983 | 4.9994 | 1.0803 | 0.9981 | 1.2611 | |
| AU565 | HER2amp | Luminal | Taxol | TUBB | TUBB | 13030.002 | uM | 0.00191 | 0.00244 | -0.8900 | -0.8727 | 4.1578 | 1.3615 | 0.9989 | 0.5732 | |
| AU565 | HER2amp | Luminal | Taxol | TUBB | TUBB | 7793.002 | uM | 0.00772 | 0.01042 | -0.8865 | -0.8641 | 3.3455 | 1.1660 | 0.9995 | 1.1545 | |
| AU565 | HER2amp | Luminal | TCS 2312 | CHK1 | CHK | 10880.152 | uM | 0.28434 | 0.39562 | -0.9128 | -0.9095 | 3.1379 | 0.6283 | 0.9992 | 1.5019 | |
| AU565 | HER2amp | Luminal | TCS PIM-1 1 | Pim kinase | PIM | 10880.148 | uM | 92.11310 | 64.4710 | 0.5895 | 0.1992 | 1.4239 | 0.0656 | 0.8672 | 1.7293 | |
| AU565 | HER2amp | Luminal | Temsirolimus | MTOR | MTOR | 10880.144 | uM | 0.22639 | 8.60380 | -0.7781 | -1.0000 | 0.3020 | 0.5884 | 0.8556 | 1.8532 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 9035.077 | uM | 0.01867 | 0.02396 | -0.4295 | -0.3234 | 1.9985 | 0.8566 | 0.9892 | 2.3909 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 9146.121 | uM | 0.01728 | 0.02395 | -0.7986 | -0.7069 | 2.6999 | 1.1222 | 0.9930 | 1.1366 | |
| AU565 | HER2amp | Luminal | Topotecan | TOP1 | TOP | 7793.007 | uM | 0.00691 | 0.01211 | -0.7351 | -0.7087 | 1.5714 | 1.2066 | 0.9991 | 1.3832 | |
| AU565 | HER2amp | Luminal | Torkinib | 15384.211 | uM | 0.00135 | 0.00371 | -0.3952 | -0.3491 | 0.5258 | 0.9632 | 0.9887 | 1.3162 | |||
| AU565 | HER2amp | Luminal | Tozasertib | AURK/FLT3/ABL/JAK2 | AURK | 10880.15 | uM | 2.73850 | 28.8840 | -0.0910 | -1.0000 | 0.4663 | 0.2379 | 0.9607 | 1.5829 |