Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | TPCA-1 | IKK | NFKB | 5900.093 | uM | inf | 0.93328 | 0.7314 | 0.7514 | 2.1906 | 0.0802 | 0.9857 | 2.3084 | |
| AU565 | HER2amp | Luminal | Trametinib | MEK | MAPK | 7793.012 | uM | inf | inf | 1.0078 | 1.0078 | 0.0000 | -0.0215 | -0.0764 | 1.1030 | |
| AU565 | HER2amp | Luminal | Trametinib | MEK | MAPK | 7793.036 | uM | 14.51550 | 16.41960 | 0.2574 | -0.4247 | 4.9882 | 0.0334 | 0.9587 | 1.0741 | |
| AU565 | HER2amp | Luminal | Trastuzumab | HER2 | ErbB | 9146.122 | uM | inf | 0.00184 | 0.5003 | 0.6442 | 5.0000 | 0.2137 | 0.8848 | 1.3408 | |
| AU565 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 5900.065 | uM | 4.26890 | 6.2930 | -0.8443 | -0.7884 | 2.4391 | 0.9271 | 0.9987 | 2.2026 | |
| AU565 | HER2amp | Luminal | Trichostatin A | HDAC | HDAC | 5901.065 | uM | 3.0340 | 4.48290 | -0.8445 | -0.8088 | 2.4647 | 0.9833 | 0.9991 | 2.0114 | |
| AU565 | HER2amp | Luminal | Triciribine | AKT | AKT | 5900.074 | uM | 0.07721 | 0.15941 | -0.5051 | -0.5223 | 0.9865 | 0.6448 | 0.9219 | 2.4189 | |
| AU565 | HER2amp | Luminal | Triciribine | AKT | AKT | 5901.074 | uM | 0.02039 | 0.16902 | -0.8539 | -0.9086 | 0.4897 | 0.7799 | 0.9864 | 1.8718 | |
| AU565 | HER2amp | Luminal | Valproic acid | HDAC | HDAC | 10880.143 | uM | 719.86770 | 1000.00000 | -0.8723 | -0.5375 | 2.2210 | 0.2818 | 0.9244 | 1.6077 | |
| AU565 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 7794.018 | uM | 0.02686 | 0.03077 | -0.6721 | -0.4598 | 4.8063 | 0.7843 | 0.9718 | 1.6812 | |
| AU565 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 9035.018 | uM | 0.00465 | 0.00516 | -0.4202 | -0.3390 | 5.0000 | 0.9224 | 0.9868 | 2.1555 | |
| AU565 | HER2amp | Luminal | Vinorelbine | TUBB | TUBB | 7793.018 | uM | 0.00513 | 0.00616 | -0.8816 | -0.7443 | 4.9977 | 1.1997 | 0.990 | 1.3186 | |
| AU565 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 5901.065 | uM | 88.2550 | 141.19540 | -0.8560 | -0.8531 | 2.1186 | 0.7219 | 0.9986 | 2.0114 | |
| AU565 | HER2amp | Luminal | Vorinostat | HDAC | HDAC | 5900.065 | uM | 97.10380 | 150.36460 | -0.8266 | -0.8361 | 2.2478 | 0.6955 | 0.9992 | 2.2026 | |
| AU565 | HER2amp | Luminal | XRP44X | ELK3 | MAPK | 10880.151 | uM | 0.36637 | 0.46911 | -0.5707 | -0.5373 | 2.9523 | 0.6965 | 0.9922 | 1.8509 | |
| AU565 | HER2amp | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14613.189 | uM | 0.29502 | 0.42857 | -0.8356 | -0.8207 | 2.6011 | 0.7518 | 0.9956 | 1.5791 | |
| AU565 | HER2amp | Luminal | Z-Leu-Leu-Norvalinal | Proteasome | Proteasome | 14113.189 | uM | 0.67853 | 0.82980 | -0.8637 | -0.8677 | 5.0000 | 0.6309 | 0.9970 | 1.4645 | |
| AU565 | HER2amp | Luminal | ZM-447439 | AURK | AURK | 10880.15 | uM | inf | 0.49203 | 0.4211 | 0.5508 | 2.4406 | 0.1717 | 0.8585 | 1.5829 | |
| BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 10581.143 | uM | 180.72220 | 1000.00000 | -0.1731 | -0.6881 | 0.5059 | 0.3625 | 0.8258 | 0.9062 | |
| BT-20 | TNBC | Basal A | 5-DFUR | TYMS | TYMS | 11854.143 | uM | 402.01920 | 550.84780 | 0.1316 | -0.1064 | 0.6126 | 0.2317 | 0.9890 | 1.1185 | |
| BT-20 | TNBC | Basal A | Afatinib | EGFR/HER2 | ErbB | 11854.158 | uM | 2.81390 | 5.67180 | -0.9160 | -0.9799 | 1.5481 | 0.4628 | 0.9583 | 1.3776 | |
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 5902.066 | uM | inf | inf | 0.9990 | 0.9990 | 0.0000 | -0.0235 | -0.9254 | 1.1775 | |
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 5903.066 | uM | inf | 8.69250 | 0.8579 | 0.8577 | 4.9852 | 0.0112 | 0.5851 | 1.1945 | |
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 5904.066 | uM | 146.75650 | 400.95450 | 0.8185 | -0.6748 | 0.8500 | 0.0076 | 0.7170 | 1.0078 | |
| BT-20 | TNBC | Basal A | AG1024 | IGF1R | RTK | 10385.066 | uM | 135.16190 | 50.65470 | 0.6488 | 0.2005 | 0.5222 | 0.0739 | 0.7320 | 0.7592 |