Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 9157.034 | uM | 0.18187 | 0.19631 | -0.9828 | -0.2326 | 5.0000 | 0.5225 | 0.7721 | 1.0593 | |
| BT-474 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 9158.121 | uM | 0.24733 | 0.27840 | -0.9861 | -0.3835 | 4.8103 | 0.5484 | 0.7794 | 1.0691 | |
| BT-474 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 7798.077 | uM | 20.15770 | 31.92150 | -0.8874 | -1.0000 | 2.3899 | 0.3002 | 0.7822 | 1.4371 | |
| BT-474 | HER2amp | Luminal | Doxorubicin | TOP2 | TOP | 9163.121 | uM | 0.18301 | 0.22105 | -1.0000 | -0.7856 | 5.0000 | 0.7812 | 0.9752 | 0.4382 | |
| BT-474 | HER2amp | Luminal | Epirubicin | TOP2 | TOP | 7798.017 | uM | inf | inf | 0.5325 | 0.5325 | 0.0000 | 0.2112 | 0.5662 | 1.4161 | |
| BT-474 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 5905.091 | uM | 10.28760 | 14.83060 | -0.3325 | -0.4346 | 1.7101 | 0.2156 | 0.9840 | 0.9045 | |
| BT-474 | HER2amp | Luminal | Erlotinib | EGFR | ErbB | 5906.091 | uM | 9.5230 | 12.88350 | -0.3869 | -0.4335 | 2.0655 | 0.1816 | 0.9899 | 0.6385 | |
| BT-474 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 5906.074 | uM | 17.11940 | 38.48220 | -0.6623 | -0.8000 | 1.1797 | 0.4139 | 0.7746 | 0.6442 | |
| BT-474 | HER2amp | Luminal | Etoposide | TOP2 | TOP | 5905.074 | uM | 21.26310 | 32.98480 | -0.2522 | -0.3378 | 1.1756 | 0.2657 | 0.990 | 0.8648 | |
| BT-474 | HER2amp | Luminal | Everolimus | MTOR | MTOR | 12178.164 | uM | 0.03693 | 1.00790 | -0.5296 | -0.7259 | 0.2712 | 0.6360 | 0.8262 | 0.5660 | |
| BT-474 | HER2amp | Luminal | Everolimus | MTOR | MTOR | 12056.164 | uM | 0.02952 | 5.5880 | -0.4510 | -1.0000 | 0.2095 | 0.6421 | 0.8685 | 0.9328 | |
| BT-474 | HER2amp | Luminal | Everolimus | MTOR | MTOR | 12291.156 | uM | 0.00176 | 0.01236 | -0.4806 | -0.4372 | 0.3227 | 0.8981 | 0.9313 | 0.5920 | |
| BT-474 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 5905.085 | uM | 0.15965 | 0.29409 | -0.9944 | -1.0000 | 1.7982 | 0.7642 | 0.9940 | 0.8847 | |
| BT-474 | HER2amp | Luminal | Fascaplysin | CDK4 | CDK | 5906.084 | uM | 0.23842 | 0.33370 | -0.9998 | -1.0000 | 3.2679 | 0.7011 | 0.9977 | 0.5452 | |
| BT-474 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 12291.166 | uM | 1.51990 | 126.88120 | -0.3155 | -1.0000 | 0.2483 | 0.4057 | 0.6108 | 0.5962 | |
| BT-474 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 12056.161 | uM | 21.72920 | 23.42150 | -0.0228 | -0.0802 | 1.9844 | 0.2123 | 0.8472 | 0.9322 | |
| BT-474 | HER2amp | Luminal | FR180204 | ERK1/2 | MAPK | 12178.161 | uM | 21.27960 | 21.61950 | -0.0407 | -0.0412 | 5.0000 | 0.1641 | 0.9209 | 0.5721 | |
| BT-474 | HER2amp | Luminal | FTase Inhibitor I | Ftase | MAPK | 12178.154 | uM | inf | inf | 0.9025 | 0.9025 | 0.0000 | -0.0179 | -0.1910 | 0.5170 | |
| BT-474 | HER2amp | Luminal | FTase Inhibitor I | Ftase | MAPK | 12056.154 | uM | inf | inf | 0.7002 | 0.7002 | 0.0000 | 0.2152 | -0.1183 | 0.9136 | |
| BT-474 | HER2amp | Luminal | FTase Inhibitor I | Ftase | MAPK | 12291.167 | uM | inf | inf | 0.6966 | 0.6966 | 0.0000 | 0.2525 | 0.0928 | 0.6147 | |
| BT-474 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 9163.024 | uM | 0.70741 | 1.59310 | -0.9996 | -1.0000 | 1.3532 | 0.6048 | 0.7473 | 0.5524 | |
| BT-474 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 9158.049 | uM | 1.82990 | 2.5510 | -1.0000 | -0.9995 | 3.3059 | 0.5005 | 0.9072 | 0.4082 | |
| BT-474 | HER2amp | Luminal | Gefitinib | EGFR | ErbB | 7797.016 | uM | 0.13057 | 0.96747 | -0.9669 | -1.0000 | 0.5485 | 0.6499 | 0.9187 | 0.5155 | |
| BT-474 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 9158.049 | uM | 0.00737 | 0.00871 | -0.8389 | -0.6523 | 5.0000 | 1.1719 | 0.9370 | 0.4082 | |
| BT-474 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 9157.012 | uM | 0.01281 | 0.01559 | -0.5634 | -0.4385 | 3.2015 | 0.9651 | 0.9914 | 0.8641 |