Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Geldanamycin | HSP90 | HSP90 | 9163.024 | uM | 0.01463 | 0.01773 | -0.8538 | -0.8081 | 5.0000 | 1.2135 | 0.9976 | 0.5524 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 9163.03 | uM | inf | inf | -0.5674 | -0.5674 | 0.0000 | 0.6950 | 0.4965 | 0.3535 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 9158.12 | uM | inf | 2.37760 | 0.6220 | 0.7678 | 4.9993 | 0.0590 | 0.610 | 0.7176 | |
| BT-474 | HER2amp | Luminal | Gemcitabine | DNA replication | DNA replication | 9163.011 | uM | inf | 0.03578 | 0.4237 | 0.5176 | 5.0000 | 0.3079 | 0.9295 | 0.6266 | |
| BT-474 | HER2amp | Luminal | Glycyl-H-1152 | ROCK2 | 12178.16 | uM | inf | inf | 0.7508 | 0.7508 | 0.0000 | 0.1609 | 0.0357 | 0.7392 | ||
| BT-474 | HER2amp | Luminal | Glycyl-H-1152 | ROCK2 | 12291.169 | uM | inf | inf | 0.8955 | 0.8955 | 0.0000 | -0.0374 | 0.1290 | 0.3548 | ||
| BT-474 | HER2amp | Luminal | Glycyl-H-1152 | ROCK2 | 12056.16 | uM | inf | inf | 0.6628 | 0.6628 | 0.0000 | 0.1074 | 0.4482 | 0.9124 | ||
| BT-474 | HER2amp | Luminal | GM6001 | MMP | MMP | 5905.096 | uM | inf | inf | 0.3979 | 0.3979 | 0.0000 | 0.1096 | 0.2122 | 0.9091 | |
| BT-474 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 9163.001 | uM | 2.92570 | 5.91270 | -0.9570 | -1.0000 | 1.5615 | 0.3033 | 0.9699 | 0.5227 | |
| BT-474 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 7798.001 | uM | 11.69510 | 28.06460 | -0.1098 | -1.0000 | 1.2551 | 0.1108 | 0.9816 | 1.3667 | |
| BT-474 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 9158.001 | uM | 5.49390 | 8.17950 | -0.9752 | -1.0000 | 2.7604 | 0.2511 | 0.9873 | 0.6988 | |
| BT-474 | HER2amp | Luminal | GSK1070916 | AURK | AURK | 9157.001 | uM | 7.18330 | 14.71620 | -0.5639 | -1.0000 | 1.5318 | 0.1471 | 0.9930 | 0.9211 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 5906.098 | uM | 269.90540 | 69.67660 | 0.7098 | 0.4039 | 1.2174 | 0.0195 | 0.8443 | 0.8050 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 5906.091 | uM | 51.04090 | 63.58320 | -0.9920 | -1.0000 | 5.0000 | 0.0972 | 0.9943 | 0.6385 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 5905.091 | uM | 6.62550 | 8.33820 | -0.9886 | -0.9895 | 4.7478 | 0.3865 | 0.9977 | 0.9045 | |
| BT-474 | HER2amp | Luminal | GSK1838705A | IGF1R | RTK | 5906.071 | uM | 6.50750 | 8.10470 | -0.9942 | -0.9981 | 4.9994 | 0.3729 | 0.9987 | 0.6917 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 9158.001 | uM | inf | inf | -0.9965 | -0.9965 | 0.0000 | 0.3194 | 0.2618 | 0.6988 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 7798.001 | uM | inf | inf | 0.2083 | 0.2083 | 0.0000 | 0.2423 | 0.3086 | 1.3667 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 9163.001 | uM | inf | inf | -0.9994 | -0.9994 | 0.0000 | 0.4623 | 0.5005 | 0.5227 | |
| BT-474 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 9157.001 | uM | 8.62370 | 11.85120 | -0.9488 | -1.0000 | 3.4557 | 0.3726 | 0.660 | 0.9211 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 9157.001 | uM | 5.53880 | 13.18950 | -0.6286 | -1.0000 | 1.2662 | 0.2774 | 0.8652 | 0.9211 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 9158.001 | uM | 0.73737 | 3.63920 | -0.9931 | -1.0000 | 0.6882 | 0.4173 | 0.8979 | 0.6988 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 9163.001 | uM | 0.08817 | 0.28093 | -0.6527 | -0.5159 | 0.6118 | 0.5320 | 0.9215 | 0.5227 | |
| BT-474 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 7798.001 | uM | 8.93030 | 17.56780 | -0.4898 | -1.0000 | 1.6237 | 0.1802 | 0.9563 | 1.3667 | |
| BT-474 | HER2amp | Luminal | GW-5074 | CRAF | MAPK | 5905.088 | uM | inf | 27.29390 | 0.8225 | 0.7214 | 2.8197 | 0.0067 | 0.7916 | 0.9646 |