Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset - HMS LINCS Database

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Small molecules	Cells	Antibodies

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Cell	Clinical Subtype	Transcriptional Subtype	Small Molecule	Perturbagen Target	Perturbagen Class	Biological Replicate ID	Conc Unit	GR50	GEC50	GRmax	GRinf	GR Hill Coefficient	GR_AOC	GR r2	Nominal Division Rate
BT-483	HR+	Luminal	NSC 663284	CDC25	CDC	11855.159	uM	1.26610	3.4830	-0.9988	-1.0000	1.0857	0.6157	0.9930	0.6347
BT-483	HR+	Luminal	NU6102	CDK1/2	CDK	11855.147	uM	inf	inf	-0.2866	-0.2866	0.0000	0.3012	0.5449	0.5719
BT-483	HR+	Luminal	NU6102	CDK1/2	CDK	10696.147	uM	18.65760	21.67560	-0.5263	-0.5330	4.8393	0.2661	0.7706	0.4763
BT-483	HR+	Luminal	Nutlin 3a	MDM2	MDM2	5908.066	uM	1.75580	21.91120	-0.4730	-1.0000	0.4353	0.4147	0.7753	0.4546
BT-483	HR+	Luminal	Olomoucine II	CDK1	CDK	10696.147	uM	5.54970	5.99530	-0.5531	-0.2357	5.0000	0.4707	0.6903	0.4763
BT-483	HR+	Luminal	Olomoucine II	CDK1	CDK	11855.147	uM	5.73430	6.35240	-0.5280	-0.3342	5.0000	0.3992	0.8806	0.5719
BT-483	HR+	Luminal	Omipalisib	PI3K	PI3K	10696.087	uM	0.00107	0.00675	-0.8871	-0.8807	0.5520	1.2219	0.9912	0.5247
BT-483	HR+	Luminal	Oxaliplatin	DNA cross-linker	DNA cross-linker	9186.119	uM	27.56870	47.01180	-0.6087	-0.6704	1.5935	0.3644	0.9657	0.4743
BT-483	HR+	Luminal	Oxamflatin	HDAC	HDAC	11855.147	uM	0.89533	3.02110	-0.9707	-1.0000	0.9033	0.6208	0.9123	0.5719
BT-483	HR+	Luminal	Oxamflatin	HDAC	HDAC	10696.147	uM	0.20002	0.97301	-0.9952	-1.0000	0.6945	0.7665	0.9378	0.4763
BT-483	HR+	Luminal	PD 98059	MEK	MAPK	11855.159	uM	85.01190	999.6660	0.4801	-0.9841	0.4414	0.1347	0.7760	0.6347
BT-483	HR+	Luminal	PD184352	MEK	MAPK	11855.155	uM	inf	inf	0.7132	0.7132	0.0000	0.3205	0.0000	0.7873
BT-483	HR+	Luminal	PD184352	MEK	MAPK	11855.155	uM	inf	inf	0.7132	0.7132	0.0000	0.3205	0.0000	0.7873
BT-483	HR+	Luminal	PD184352	MEK	MAPK	10696.146	uM	inf	inf	0.6829	0.6829	0.0000	0.1390	0.0199	0.5009
BT-483	HR+	Luminal	PD184352	MEK	MAPK	10696.146	uM	inf	inf	0.6829	0.6829	0.0000	0.1390	0.0199	0.5009
BT-483	HR+	Luminal	Pemetrexed	TYMS/DHFR/GARFT	TYMS	5908.095	uM	inf	inf	0.4981	0.4981	0.0000	0.4703	0.3268	0.5012
BT-483	HR+	Luminal	PS-1145	IKK	NFKB	5908.065	uM	inf	inf	0.9395	0.9395	0.0000	0.1159	0.0000	0.5136
BT-483	HR+	Luminal	Purvalanol A	CDK1	CDK	5908.067	uM	inf	inf	0.2417	0.2417	0.0000	0.3277	0.4524	0.5143
BT-483	HR+	Luminal	SB-3CT	MMP2/9	MMP	10696.144	uM	16.93840	48.89730	-0.4086	-1.0000	1.0363	0.3193	0.7765	0.4505
BT-483	HR+	Luminal	SB-3CT	MMP2/9	MMP	11855.144	uM	22.49410	33.36110	-0.9217	-1.0000	2.7874	0.2982	0.9251	0.5961
BT-483	HR+	Luminal	Selumetinib	MEK	MAPK	11855.155	uM	inf	inf	0.7745	0.7745	0.0000	0.2804	0.0000	0.7873
BT-483	HR+	Luminal	Selumetinib	MEK	MAPK	10696.146	uM	inf	inf	0.6118	0.6118	0.0000	0.1876	0.4154	0.5009
BT-483	HR+	Luminal	Sigma A6730	AKT	AKT	11855.158	uM	0.14373	3.28620	-0.6376	-1.0000	0.3511	0.6088	0.9430	0.6941
BT-483	HR+	Luminal	Sigma A6730	AKT	AKT	10696.153	uM	1.1750	2.84060	-0.6524	-0.6846	0.9772	0.4348	0.9803	0.5484
BT-483	HR+	Luminal	Sirolimus	MTOR	MTOR	5908.069	uM	0.00124	0.00074	0.1221	0.1875	0.9066	0.6615	0.9618	0.6014

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HMS LINCS Project

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)