Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-474 | HER2amp | Luminal | Ibandronate | FDPS | 12291.143 | uM | 55.44380 | 60.20880 | -0.3042 | -0.2551 | 5.0000 | 0.3387 | 0.9463 | 0.5621 | ||
| BT-474 | HER2amp | Luminal | Ibandronate | FDPS | 12056.143 | uM | 105.67990 | 99.8620 | 0.0633 | 0.0434 | 1.6030 | 0.2369 | 0.9811 | 1.0075 | ||
| BT-474 | HER2amp | Luminal | Ibandronate | FDPS | 12178.143 | uM | 90.5610 | 96.26080 | -0.0502 | -0.0666 | 2.0474 | 0.2416 | 0.9876 | 0.7617 | ||
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 12178.157 | uM | inf | inf | 0.8714 | 0.8714 | 0.0000 | -0.0235 | -0.1217 | 0.5528 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 12056.157 | uM | inf | inf | 0.8491 | 0.8491 | 0.0000 | 0.0630 | 0.0552 | 0.9748 | |
| BT-474 | HER2amp | Luminal | ICRF-193 | TOP2 | TOP | 12291.157 | uM | inf | inf | 0.6757 | 0.6757 | 0.0000 | 0.1553 | 0.1959 | 0.5161 | |
| BT-474 | HER2amp | Luminal | IKK16 | IKK | NFKB | 5905.093 | uM | 5.12020 | 6.37670 | -0.9852 | -0.9980 | 5.0000 | 0.3407 | 0.9979 | 0.9101 | |
| BT-474 | HER2amp | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 5906.091 | uM | 25.84750 | 33.13470 | -0.9991 | -0.9973 | 4.4161 | 0.3903 | 0.9962 | 0.6385 | |
| BT-474 | HER2amp | Luminal | Imatinib | ABL/KIT/PDGFR | nRTK | 5905.091 | uM | 28.23360 | 37.99870 | -0.9923 | -0.9929 | 3.6826 | 0.3839 | 0.9975 | 0.9045 | |
| BT-474 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 5905.067 | uM | 0.03788 | 0.21488 | -0.9965 | -1.0000 | 0.6329 | 0.7563 | 0.9348 | 0.7991 | |
| BT-474 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 5906.067 | uM | 0.06421 | 0.14736 | -0.9982 | -0.8609 | 1.2053 | 0.7417 | 0.9670 | 0.6838 | |
| BT-474 | HER2amp | Luminal | Ixabepilone | TUBB | TUBB | 5906.095 | uM | 0.00127 | 0.00167 | -0.9990 | -0.3324 | 1.8966 | 0.9953 | 0.6890 | 0.6731 | |
| BT-474 | HER2amp | Luminal | Ixabepilone | TUBB | TUBB | 5905.095 | uM | 0.01024 | 0.01214 | -0.9837 | -0.1871 | 1.8629 | 0.6903 | 0.7158 | 0.9590 | |
| BT-474 | HER2amp | Luminal | JNK-IN-5A | JNK | JNK | 12178.144 | uM | inf | inf | 0.6802 | 0.6802 | 0.0000 | 0.1793 | -0.0043 | 0.7891 | |
| BT-474 | HER2amp | Luminal | JNK-IN-5A | JNK | JNK | 12056.144 | uM | inf | inf | 0.8442 | 0.8442 | 0.0000 | 0.0965 | 0.2228 | 0.9738 | |
| BT-474 | HER2amp | Luminal | JNK-IN-5A | JNK | JNK | 12291.168 | uM | 0.29640 | 0.52747 | -0.4339 | -0.3894 | 0.9993 | 0.6336 | 0.9558 | 0.4466 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 12291.166 | uM | inf | inf | 0.1392 | 0.1392 | 0.0000 | 0.2732 | 0.4769 | 0.5962 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 12056.161 | uM | 15.59410 | 20.71890 | -0.9365 | -1.0000 | 3.8662 | 0.1574 | 0.9765 | 0.9322 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 12178.161 | uM | 19.47710 | 26.61580 | -0.8005 | -0.9971 | 3.5119 | 0.1023 | 0.9928 | 0.5721 | |
| BT-474 | HER2amp | Luminal | Lapatinib | EGFR/HER2 | ErbB | 5906.098 | uM | 0.37630 | 0.62083 | -0.5961 | -0.6214 | 1.6133 | 0.4221 | 0.9983 | 0.8050 | |
| BT-474 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 12291.167 | uM | 0.02976 | 0.07035 | -0.9929 | -1.0000 | 1.2770 | 1.0038 | 0.9817 | 0.6147 | |
| BT-474 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 12056.154 | uM | 0.02489 | 0.06655 | -0.9572 | -1.0000 | 1.1169 | 1.0106 | 0.9861 | 0.9136 | |
| BT-474 | HER2amp | Luminal | LBH589 | HDAC | HDAC | 12178.154 | uM | 0.08694 | 0.13176 | -0.9950 | -0.9962 | 2.6365 | 0.8387 | 0.9988 | 0.5170 | |
| BT-474 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 12291.167 | uM | 0.17899 | 0.78726 | -0.9985 | -1.0000 | 0.7417 | 0.6687 | 0.9497 | 0.6147 | |
| BT-474 | HER2amp | Luminal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 12056.154 | uM | 0.20882 | 1.22190 | -0.9867 | -1.0000 | 0.6219 | 0.5721 | 0.9681 | 0.9136 |