Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Biological Replicate ID | Conc Unit | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR r2 | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184A1 | NM | Basal | GSK1838705A | IGF1R | RTK | 5895.091 | uM | 0.38664 | 0.64104 | -0.6029 | -0.4621 | 1.2945 | 0.5672 | 0.9684 | 1.1729 | |
| 184A1 | NM | Basal | GSK1838705A | IGF1R | RTK | 5895.098 | uM | 0.42849 | 0.39937 | 0.0166 | 0.0538 | 1.6165 | 0.3574 | 0.9937 | 1.4041 | |
| 184A1 | NM | Basal | GSK1838705A | IGF1R | RTK | 5894.098 | uM | 0.36902 | 0.35227 | 0.0333 | 0.0487 | 2.2061 | 0.3782 | 0.9970 | 1.6523 | |
| 184A1 | NM | Basal | GSK461364 | PLK1 | PLK | 9047.001 | uM | 4.15810 | 52.44110 | -0.0073 | -1.0000 | 0.4334 | 0.2620 | 0.7464 | 0.7701 | |
| 184A1 | NM | Basal | GSK461364 | PLK1 | PLK | 10002.001 | uM | 6.06620 | 9.11620 | -0.9717 | -1.0000 | 2.6972 | 0.2605 | 0.9735 | 0.5372 | |
| 184A1 | NM | Basal | GSK923295 | CENPE | Kinesin | 9047.001 | uM | inf | inf | 0.0385 | 0.0385 | 0.0000 | 0.2510 | 0.5226 | 0.7701 | |
| 184A1 | NM | Basal | GSK923295 | CENPE | Kinesin | 10002.001 | uM | 8.47170 | 11.6240 | -0.9507 | -1.0000 | 3.4729 | 0.2407 | 0.9439 | 0.5372 | |
| 184A1 | NM | Basal | GW-5074 | CRAF | MAPK | 5895.088 | uM | 2.20640 | 4.30790 | -0.5359 | -0.6571 | 1.2540 | 0.2508 | 0.9932 | 1.3297 | |
| 184A1 | NM | Basal | Ibandronate | FDPS | 12509.143 | uM | 155.22840 | 288.34070 | -0.9140 | -1.0000 | 1.7741 | 0.2785 | 0.9964 | 1.3392 | ||
| 184A1 | NM | Basal | ICRF-193 | TOP2 | TOP | 12509.157 | uM | inf | 0.17119 | 0.6433 | 0.6783 | 0.6598 | 0.1328 | 0.9202 | 1.2837 | |
| 184A1 | NM | Basal | IKK16 | IKK | NFKB | 5895.093 | uM | 1.01110 | 2.37210 | -0.9564 | -1.0000 | 1.2884 | 0.5085 | 0.9882 | 1.3259 | |
| 184A1 | NM | Basal | Imatinib | ABL/KIT/PDGFR | nRTK | 5895.091 | uM | 16.09010 | 26.49230 | -0.9899 | -1.0000 | 2.2032 | 0.4630 | 0.9969 | 1.1729 | |
| 184A1 | NM | Basal | Ispinesib | KSP | Kinesin | 5894.067 | uM | 1.62180 | 3.48940 | -0.9288 | -1.0000 | 1.4339 | 0.3983 | 0.9581 | 1.5647 | |
| 184A1 | NM | Basal | Ispinesib | KSP | Kinesin | 5895.067 | uM | 2.25070 | 4.57410 | -0.9091 | -1.0000 | 1.5491 | 0.3497 | 0.9692 | 1.4053 | |
| 184A1 | NM | Basal | Ixabepilone | TUBB | TUBB | 5895.095 | uM | 0.14338 | 0.76637 | -0.9501 | -1.0000 | 0.6554 | 0.6829 | 0.9483 | 1.4629 | |
| 184A1 | NM | Basal | Ixabepilone | TUBB | TUBB | 5894.095 | uM | 0.46640 | 0.69919 | -0.9010 | -0.8976 | 2.5388 | 0.6159 | 0.9985 | 1.7133 | |
| 184A1 | NM | Basal | JNK-IN-5A | JNK | JNK | 12509.168 | uM | inf | 0.95387 | 0.3859 | 0.6171 | 4.9990 | 0.1487 | 0.7274 | 1.3516 | |
| 184A1 | NM | Basal | L-779450 | BRAF | MAPK | 12509.166 | uM | 8.56520 | 14.40640 | -0.7107 | -1.0000 | 2.1129 | 0.1672 | 0.9687 | 1.2847 | |
| 184A1 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 5895.098 | uM | 1.84620 | 1.07940 | 0.2337 | 0.4659 | 5.0000 | 0.0845 | 0.8011 | 1.4041 | |
| 184A1 | NM | Basal | Lapatinib | EGFR/HER2 | ErbB | 5894.098 | uM | 1.96260 | 1.83210 | 0.0794 | 0.0736 | 2.3169 | 0.1499 | 0.9957 | 1.6523 | |
| 184A1 | NM | Basal | LBH589 | HDAC | HDAC | 12509.167 | uM | 0.29923 | 0.89089 | -0.7415 | -0.8021 | 0.8773 | 0.4884 | 0.9905 | 1.4256 | |
| 184A1 | NM | Basal | Lestaurtinib | FLT3/JAK2/TrkA | RTK | 12509.167 | uM | 1.46780 | 2.26520 | -0.8669 | -0.8656 | 2.3156 | 0.3809 | 0.9959 | 1.4256 | |
| 184A1 | NM | Basal | Mebendazole | 12684.174 | uM | inf | 0.36667 | 0.5334 | 0.5745 | 5.0000 | 0.1723 | 0.9699 | 1.4645 | |||
| 184A1 | NM | Basal | Methotrexate | DHFR | Metabolism | 5894.084 | uM | 0.05840 | 0.06456 | -0.2992 | -0.3127 | 4.8467 | 0.9024 | 0.9966 | 1.5903 | |
| 184A1 | NM | Basal | Methotrexate | DHFR | Metabolism | 5895.085 | uM | 0.05117 | 0.05935 | -0.3071 | -0.3193 | 3.3302 | 0.8875 | 0.9988 | 1.4396 |