Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset - HMS LINCS Database

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Small molecules	Cells	Antibodies

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Cell	Clinical Subtype	Transcriptional Subtype	Small Molecule	Perturbagen Target	Perturbagen Class	Biological Replicate ID	Conc Unit	GR50	GEC50	GRmax	GRinf	GR Hill Coefficient	GR_AOC	GR r2	Nominal Division Rate
184A1	NM	Basal	MG-132	Proteasome	Proteasome	12509.17	uM	0.02024	0.05106	-0.8085	-0.6493	0.8994	0.9276	0.9449	1.3955
184A1	NM	Basal	MG-132	Proteasome	Proteasome	12509.17	uM	0.02024	0.05106	-0.8085	-0.6493	0.8994	0.9276	0.9449	1.3955
184A1	NM	Basal	Pevonedistat	NAE1	NAE1	12509.135	uM	0.63324	0.71207	-0.0395	-0.0415	0.6794	0.3594	0.9880	1.3717
184A1	NM	Basal	Nelfinavir			12684.174	uM	3.030	4.22870	-0.6445	-0.6543	2.5101	0.2990	0.9857	1.4645
184A1	NM	Basal	Nilotinib	ABL	nRTK	12509.17	uM	inf	0.16976	0.8260	0.8615	1.0340	0.0781	0.8007	1.3955
184A1	NM	Basal	NSC 663284	CDC25	CDC	12509.152	uM	1.61730	2.02890	-0.9303	-0.9290	4.6320	0.6528	0.9971	1.3755
184A1	NM	Basal	NU6102	CDK1/2	CDK	12509.147	uM	6.59190	12.95280	-0.8721	-1.0000	1.6264	0.2474	0.9935	1.2058
184A1	NM	Basal	Nutlin 3a	MDM2	MDM2	5894.066	uM	6.76640	16.58460	-0.8949	-1.0000	1.2254	0.2778	0.9387	1.5027
184A1	NM	Basal	Nutlin 3a	MDM2	MDM2	5895.066	uM	3.22280	10.22950	-0.9725	-1.0000	0.9512	0.3133	0.9559	1.1612
184A1	NM	Basal	Olomoucine II	CDK1	CDK	12509.147	uM	3.35230	4.08990	-0.3436	-0.3230	2.5061	0.3311	0.9956	1.2058
184A1	NM	Basal	Omipalisib	PI3K	PI3K	5895.086	uM	0.00183	0.00262	-0.5032	-0.1746	0.8363	0.8309	0.9163	1.2802
184A1	NM	Basal	Oxaliplatin	DNA cross-linker	DNA cross-linker	10002.021	uM	1.98010	5.92780	-0.9908	-1.0000	1.0019	0.7527	0.9764	0.7195
184A1	NM	Basal	Oxaliplatin	DNA cross-linker	DNA cross-linker	9047.011	uM	0.53932	2.18460	-0.9996	-1.0000	0.7854	0.8887	0.9928	0.6293
184A1	NM	Basal	Oxamflatin	HDAC	HDAC	12509.147	uM	1.65310	3.49760	-0.9533	-1.0000	1.4659	0.4736	0.9918	1.2058
184A1	NM	Basal	PD 98059	MEK	MAPK	12509.152	uM	inf	inf	0.7622	0.7622	0.0000	0.0595	0.4482	1.3755
184A1	NM	Basal	PD173074	FGFR1/3	RTK	5895.093	uM	8.46530	9.95550	-0.0760	-0.1823	1.9169	0.0959	0.9866	1.3259
184A1	NM	Basal	PD184352	MEK	MAPK	12509.155	uM	8.55920	48.2470	0.1172	-1.0000	0.6353	0.1432	0.9509	1.3444
184A1	NM	Basal	PD184352	MEK	MAPK	12509.155	uM	8.55920	48.2470	0.1172	-1.0000	0.6353	0.1432	0.9509	1.3444
184A1	NM	Basal	Pemetrexed	TYMS/DHFR/GARFT	TYMS	5894.095	uM	53.72510	62.72890	-0.1792	-0.0920	1.0901	0.3508	0.940	1.7133
184A1	NM	Basal	Pemetrexed	TYMS/DHFR/GARFT	TYMS	5895.095	uM	0.40767	0.41810	-0.0165	-0.0219	1.6956	0.7104	0.9924	1.4629
184A1	NM	Basal	PS-1145	IKK	NFKB	5895.065	uM	inf	inf	1.0031	1.0031	0.0000	-0.0389	-4.6402	1.3748
184A1	NM	Basal	PS-1145	IKK	NFKB	5894.065	uM	inf	416.61250	0.8384	0.8383	4.9997	-0.0087	0.7490	1.6064
184A1	NM	Basal	Purvalanol A	CDK1	CDK	5895.067	uM	51.18430	39.92310	0.3558	0.3553	4.9894	0.0457	0.9764	1.4053
184A1	NM	Basal	Purvalanol A	CDK1	CDK	5894.067	uM	6.00880	4.73440	0.1064	0.1488	1.4817	0.2344	0.9798	1.5647
184A1	NM	Basal	QNZ	NFkB	NFKB	5895.096	uM	97.09330	12.46050	0.5808	0.2658	0.3693	0.1340	0.8974	1.4232

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HMS LINCS Project

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)