Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset - HMS LINCS Database

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)

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Small molecules	Cells	Antibodies

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Cell	Clinical Subtype	Transcriptional Subtype	Small Molecule	Antibody	Perturbagen Target	Perturbagen Class	Biological Replicate ID	Conc Unit	GR50	GEC50	GRmax	GRinf	GR Hill Coefficient	GR_AOC	GR r2	Nominal Division Rate
184A1	NM	Basal	SB-3CT		MMP2/9	MMP	12509.168	uM	433.25760	1000.00000	0.6180	-0.2672	0.5118	0.0585	0.8869	1.3516
184A1	NM	Basal	Selumetinib		MEK	MAPK	12509.155	uM	0.33719	0.32458	0.0422	0.0182	0.9722	0.3745	0.9924	1.3444
184A1	NM	Basal	Sigma A6730		AKT	AKT	12509.165	uM	3.14240	13.05610	-0.6553	-1.0000	0.7714	0.3161	0.9885	1.5022
184A1	NM	Basal	Sirolimus		MTOR	MTOR	7787.068	uM	inf	inf	-0.2794	-0.2794	0.0000	0.5821	0.4995	0.9562
184A1	NM	Basal	Sorafenib		PDGFR/VEGFR/KIT/FLT3	RTK	5895.085	uM	1.60350	2.04080	-0.6352	-0.4548	2.6820	0.5481	0.9684	1.4396
184A1	NM	Basal	Sorafenib		PDGFR/VEGFR/KIT/FLT3	RTK	5894.084	uM	3.93680	6.19440	-0.5995	-0.4573	1.4330	0.5586	0.9851	1.5903
184A1	NM	Basal	Sunitinib		PDGFR/VEGFR/KIT/FLT3	RTK	5894.067	uM	4.440	8.19730	-0.9413	-0.9957	1.7870	0.4582	0.9949	1.5647
184A1	NM	Basal	Sunitinib		PDGFR/VEGFR/KIT/FLT3	RTK	5895.067	uM	5.42490	7.97390	-0.9135	-0.9079	2.6878	0.4188	0.9982	1.4053
184A1	NM	Basal	TAPI-0		TACE/Collagenase		5895.096	uM	inf	6.62580	0.8804	0.8803	5.0000	-0.0065	0.5959	1.4232
184A1	NM	Basal	Taxol		TUBB	TUBB	9047.002	uM	0.05134	0.13706	-0.1958	-0.2758	0.4473	0.5388	0.9220	0.5243
184A1	NM	Basal	Taxol		TUBB	TUBB	12684.002	uM	inf	0.01616	0.4397	0.5237	1.5161	0.2820	0.9561	1.5245
184A1	NM	Basal	Taxol		TUBB	TUBB	10002.002	uM	0.03993	0.01744	0.3992	0.4147	2.1347	0.3380	0.9787	0.9502
184A1	NM	Basal	TCS 2312		CHK1	CHK	12509.152	uM	0.52576	0.68654	-0.6028	-0.3929	2.1732	0.3972	0.9705	1.3755
184A1	NM	Basal	TCS PIM-1 1		Pim kinase	PIM	12509.135	uM	11.05020	2.4860	0.3652	0.3169	0.6733	0.2265	0.9787	1.3717
184A1	NM	Basal	Temsirolimus		MTOR	MTOR	12509.168	uM	0.69862	4.34640	-0.9247	-1.0000	0.6010	0.6200	0.8824	1.3516
184A1	NM	Basal	Topotecan		TOP1	TOP	9047.121	uM	0.06571	0.20129	-0.5195	-0.5794	0.6874	0.8137	0.9412	0.7949
184A1	NM	Basal	Tozasertib		AURK/FLT3/ABL/JAK2	AURK	12509.169	uM	2.47570	23.78060	-0.3199	-1.0000	0.4856	0.3696	0.9823	1.5064
184A1	NM	Basal	TPCA-1		IKK	NFKB	5895.093	uM	4.52640	2.6040	0.3659	0.3912	2.7579	0.1290	0.9836	1.3259
184A1	NM	Basal	Trametinib		MEK	MAPK	9047.012	uM	0.00121	0.00198	-0.2658	-0.2622	0.8548	0.8904	0.9728	0.7549
184A1	NM	Basal	Trametinib		MEK	MAPK	10002.012	uM	0.00246	0.00373	-0.3319	-0.3425	1.2572	0.8816	0.9950	0.5807
184A1	NM	Basal		Trastuzumab	HER2	ErbB	9047.026	uM	inf	inf	0.2837	0.2837	0.0000	0.2170	0.0804	0.5972
184A1	NM	Basal	Trichostatin A		HDAC	HDAC	5895.065	uM	18.79790	50.3060	-0.9456	-0.9673	1.0936	0.6799	0.9969	1.3748
184A1	NM	Basal	Trichostatin A		HDAC	HDAC	5894.065	uM	21.390	58.12760	-0.8469	-0.8364	0.9834	0.6280	0.9974	1.6064
184A1	NM	Basal	Triciribine		AKT	AKT	5894.074	uM	0.10268	0.28489	-0.6622	-0.6112	0.7825	0.5807	0.9866	1.4541
184A1	NM	Basal	Triciribine		AKT	AKT	5895.074	uM	0.08792	0.23992	-0.7686	-0.7129	0.8827	0.6419	0.9956	1.1218

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HMS LINCS Project

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 2 of 4: Calculated dose-response metrics. - Dataset (ID:20269)