Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 0.0128 | uM | 7825.018 | 0.9615 | 0.9606 | 1.9741 | ||
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 0.064 | uM | 7825.018 | 0.9439 | 0.9423 | 1.9741 | ||
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 0.32 | uM | 7825.018 | 0.8832 | 0.8780 | 1.9741 | ||
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 1.6 | uM | 7825.018 | 0.5755 | 0.5117 | 1.9741 | ||
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 8 | uM | 7825.018 | 0.6396 | 0.5948 | 1.9741 | ||
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 40 | uM | 7825.018 | 0.6444 | 0.6008 | 1.9741 | ||
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 200 | uM | 7825.018 | 0.6183 | 0.5677 | 1.9741 | ||
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 1000 | uM | 7825.018 | 0.4673 | 0.3604 | 1.9741 | ||
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 5000 | uM | 7825.018 | 0.1419 | -0.2561 | 1.9741 | ||
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 0.0128 | uM | 9347.026 | 1.0995 | 1.1519 | 1.2965 | ||
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 0.064 | uM | 9347.026 | 0.9688 | 0.9517 | 1.2965 | ||
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 0.32 | uM | 9347.026 | 1.0063 | 1.0097 | 1.2965 | ||
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 1.6 | uM | 9347.026 | 0.8198 | 0.7158 | 1.2965 | ||
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 8 | uM | 9347.026 | 0.8646 | 0.7878 | 1.2965 | ||
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 40 | uM | 9347.026 | 0.7975 | 0.6797 | 1.2965 | ||
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 200 | uM | 9347.026 | 0.7173 | 0.5479 | 1.2965 | ||
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 1000 | uM | 9347.026 | 0.6559 | 0.4446 | 1.2965 | ||
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 5000 | uM | 9347.026 | 0.2509 | -0.3117 | 1.2965 | ||
| HCC1806 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 0.0128 | uM | 7830.018 | 1.1969 | 1.2489 | 1.5320 | ||
| HCC1806 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 0.064 | uM | 7830.018 | 1.3476 | 1.4300 | 1.5320 | ||
| HCC1806 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 0.32 | uM | 7830.018 | 1.0481 | 1.0623 | 1.5320 | ||
| HCC1806 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 1.6 | uM | 7830.018 | 0.9316 | 0.9096 | 1.5320 | ||
| HCC1806 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 8 | uM | 7830.018 | 0.9278 | 0.9045 | 1.5320 | ||
| HCC1806 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 40 | uM | 7830.018 | 0.8380 | 0.7821 | 1.5320 | ||
| HCC1806 | TNBC | Basal A | CGC-11047 | Polyamine analogue | 200 | uM | 7830.018 | 0.7079 | 0.5962 | 1.5320 |