Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.32 | uM | 9294.125 | 0.8990 | 0.7178 | 0.6999 | ||
| HCC1428 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 1.6 | uM | 9294.125 | 0.7709 | 0.3792 | 0.6999 | ||
| HCC1428 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 8 | uM | 9294.125 | 0.7609 | 0.3536 | 0.6999 | ||
| HCC1428 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 40 | uM | 9294.125 | 0.7529 | 0.3333 | 0.6999 | ||
| HCC1428 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 200 | uM | 9294.125 | 0.8140 | 0.4905 | 0.6999 | ||
| HCC1428 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 1000 | uM | 9294.125 | 0.5244 | -0.2047 | 0.6999 | ||
| HCC1428 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 5000 | uM | 9294.125 | 0.0077 | -0.9981 | 0.6999 | ||
| HCC1428 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.0128 | uM | 10031.034 | 1.0764 | 1.1912 | 0.8064 | ||
| HCC1428 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.064 | uM | 10031.034 | 0.9350 | 0.8401 | 0.8064 | ||
| HCC1428 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 0.32 | uM | 10031.034 | 1.0111 | 1.0275 | 0.8064 | ||
| HCC1428 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 1.6 | uM | 10031.034 | 0.8374 | 0.6050 | 0.8064 | ||
| HCC1428 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 8 | uM | 10031.034 | 0.8719 | 0.6875 | 0.8064 | ||
| HCC1428 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 40 | uM | 10031.034 | 0.8704 | 0.6837 | 0.8064 | ||
| HCC1428 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 200 | uM | 10031.034 | 0.8255 | 0.5768 | 0.8064 | ||
| HCC1428 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 1000 | uM | 10031.034 | 0.4588 | -0.2389 | 0.8064 | ||
| HCC1428 | HR+ | Luminal | CGC-11047 | Polyamine analogue | 5000 | uM | 10031.034 | 0.0102 | -0.9933 | 0.8064 | ||
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 0.0128 | uM | 7824.018 | 1.1360 | 1.2042 | 1.3115 | ||
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 0.064 | uM | 7824.018 | 1.0890 | 1.1344 | 1.3115 | ||
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 0.32 | uM | 7824.018 | 1.0514 | 1.0780 | 1.3115 | ||
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 1.6 | uM | 7824.018 | 0.9036 | 0.8512 | 1.3115 | ||
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 8 | uM | 7824.018 | 0.8890 | 0.8284 | 1.3115 | ||
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 40 | uM | 7824.018 | 0.8112 | 0.7050 | 1.3115 | ||
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 200 | uM | 7824.018 | 0.8019 | 0.6901 | 1.3115 | ||
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 1000 | uM | 7824.018 | 0.5672 | 0.2979 | 1.3115 | ||
| HCC1569 | HER2amp | Basal A | CGC-11047 | Polyamine analogue | 5000 | uM | 7824.018 | 0.3097 | -0.1818 | 1.3115 |