Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.32 | uM | 9035.018 | 0.7876 | 0.7903 | 2.1555 | ||
| AU565 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 1.6 | uM | 9035.018 | 0.7175 | 0.7145 | 2.1555 | ||
| AU565 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 8 | uM | 9035.018 | 0.7211 | 0.7184 | 2.1555 | ||
| AU565 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 40 | uM | 9035.018 | 0.7701 | 0.7717 | 2.1555 | ||
| AU565 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 200 | uM | 9035.018 | 0.6952 | 0.6895 | 2.1555 | ||
| AU565 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 1000 | uM | 9035.018 | 0.5815 | 0.5553 | 2.1555 | ||
| AU565 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 5000 | uM | 9035.018 | 0.3249 | 0.1872 | 2.1555 | ||
| AU565 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.0000853 | uM | 9146.122 | 0.9271 | 0.8902 | 1.3408 | ||
| AU565 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.000427 | uM | 9146.122 | 0.9846 | 0.9770 | 1.3408 | ||
| AU565 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.00213 | uM | 9146.122 | 1.0822 | 1.1214 | 1.3408 | ||
| AU565 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.0107 | uM | 9146.122 | 0.9983 | 0.9975 | 1.3408 | ||
| AU565 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.0533 | uM | 9146.122 | 1.0815 | 1.1203 | 1.3408 | ||
| AU565 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.267 | uM | 9146.122 | 0.8856 | 0.8267 | 1.3408 | ||
| AU565 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 1.33 | uM | 9146.122 | 0.7999 | 0.6933 | 1.3408 | ||
| AU565 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 6.67 | uM | 9146.122 | 0.7425 | 0.6018 | 1.3408 | ||
| AU565 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 33.3 | uM | 9146.122 | 0.7122 | 0.5528 | 1.3408 | ||
| BT-474 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.0128 | uM | 7798.018 | 1.0242 | 1.0334 | 1.4461 | ||
| BT-474 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.064 | uM | 7798.018 | 0.9997 | 0.9996 | 1.4461 | ||
| BT-474 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 0.32 | uM | 7798.018 | 1.0272 | 1.0374 | 1.4461 | ||
| BT-474 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 1.6 | uM | 7798.018 | 0.8699 | 0.8162 | 1.4461 | ||
| BT-474 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 8 | uM | 7798.018 | 0.8635 | 0.8070 | 1.4461 | ||
| BT-474 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 40 | uM | 7798.018 | 0.7952 | 0.7069 | 1.4461 | ||
| BT-474 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 200 | uM | 7798.018 | 0.8457 | 0.7811 | 1.4461 | ||
| BT-474 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 1000 | uM | 7798.018 | 0.5626 | 0.3437 | 1.4461 | ||
| BT-474 | HER2amp | Luminal | CGC-11047 | Polyamine analogue | 5000 | uM | 7798.018 | 0.0257 | -0.8409 | 1.4461 |