Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 20 | uM | 9294.037 | 0.3795 | -0.3997 | 0.8050 | |
| HCC1428 | HR+ | Luminal | 17-AAG | HSP90 | HSP90 | 100 | uM | 9294.037 | 0.0109 | -0.9927 | 0.8050 | |
| HCC1569 | HER2amp | Basal A | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7825.05 | 0.9915 | 0.9907 | 1.8354 | |
| HCC1569 | HER2amp | Basal A | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7825.05 | 1.0546 | 1.0587 | 1.8354 | |
| HCC1569 | HER2amp | Basal A | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7825.05 | 0.9795 | 0.9776 | 1.8354 | |
| HCC1569 | HER2amp | Basal A | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7825.05 | 1.0441 | 1.0476 | 1.8354 | |
| HCC1569 | HER2amp | Basal A | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7825.05 | 0.5549 | 0.4510 | 1.8354 | |
| HCC1569 | HER2amp | Basal A | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 7825.05 | 0.3204 | 0.0758 | 1.8354 | |
| HCC1569 | HER2amp | Basal A | 17-AAG | HSP90 | HSP90 | 4 | uM | 7825.05 | 0.3025 | 0.0425 | 1.8354 | |
| HCC1569 | HER2amp | Basal A | 17-AAG | HSP90 | HSP90 | 20 | uM | 7825.05 | 0.2158 | -0.1328 | 1.8354 | |
| HCC1569 | HER2amp | Basal A | 17-AAG | HSP90 | HSP90 | 100 | uM | 7825.05 | 0.1008 | -0.4272 | 1.8354 | |
| HCC1569 | HER2amp | Basal A | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 9347.037 | 0.9822 | 0.9776 | 1.5927 | |
| HCC1569 | HER2amp | Basal A | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 9347.037 | 0.9768 | 0.9708 | 1.5927 | |
| HCC1569 | HER2amp | Basal A | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 9347.037 | 1.0216 | 1.0270 | 1.5927 | |
| HCC1569 | HER2amp | Basal A | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 9347.037 | 0.8959 | 0.8666 | 1.5927 | |
| HCC1569 | HER2amp | Basal A | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 9347.037 | 0.5937 | 0.4416 | 1.5927 | |
| HCC1569 | HER2amp | Basal A | 17-AAG | HSP90 | HSP90 | 0.8 | uM | 9347.037 | 0.3255 | -0.0115 | 1.5927 | |
| HCC1569 | HER2amp | Basal A | 17-AAG | HSP90 | HSP90 | 4 | uM | 9347.037 | 0.3034 | -0.0542 | 1.5927 | |
| HCC1569 | HER2amp | Basal A | 17-AAG | HSP90 | HSP90 | 20 | uM | 9347.037 | 0.1908 | -0.2931 | 1.5927 | |
| HCC1569 | HER2amp | Basal A | 17-AAG | HSP90 | HSP90 | 100 | uM | 9347.037 | 0.1411 | -0.4151 | 1.5927 | |
| HCC1806 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.000256 | uM | 7829.04 | 1.0294 | 1.0300 | 1.9437 | |
| HCC1806 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.00128 | uM | 7829.04 | 0.9619 | 0.9604 | 1.9437 | |
| HCC1806 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.0064 | uM | 7829.04 | 1.0051 | 1.0053 | 1.9437 | |
| HCC1806 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.032 | uM | 7829.04 | 0.9659 | 0.9646 | 1.9437 | |
| HCC1806 | TNBC | Basal A | 17-AAG | HSP90 | HSP90 | 0.16 | uM | 7829.04 | 0.4184 | 0.2775 | 1.9437 |