Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.000427 | uM | 10693.153 | 0.9127 | 0.7876 | 0.8137 | |
| HCC1428 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.00213 | uM | 10693.153 | 0.9644 | 0.9129 | 0.8137 | |
| HCC1428 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0107 | uM | 10693.153 | 0.9595 | 0.9009 | 0.8137 | |
| HCC1428 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0533 | uM | 10693.153 | 0.9980 | 0.9950 | 0.8137 | |
| HCC1428 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.267 | uM | 10693.153 | 0.9950 | 0.9876 | 0.8137 | |
| HCC1428 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 1.33 | uM | 10693.153 | 0.9454 | 0.8667 | 0.8137 | |
| HCC1428 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 6.67 | uM | 10693.153 | 0.7864 | 0.4886 | 0.8137 | |
| HCC1428 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 33.3 | uM | 10693.153 | 0.5821 | 0.0285 | 0.8137 | |
| HCC1428 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.000171 | uM | 11936.158 | 0.9764 | 0.9367 | 0.7417 | |
| HCC1428 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.000853 | uM | 11936.158 | 0.9142 | 0.7721 | 0.7417 | |
| HCC1428 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.00427 | uM | 11936.158 | 0.9840 | 0.9569 | 0.7417 | |
| HCC1428 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0213 | uM | 11936.158 | 0.9779 | 0.9407 | 0.7417 | |
| HCC1428 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.107 | uM | 11936.158 | 0.9477 | 0.8602 | 0.7417 | |
| HCC1428 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.533 | uM | 11936.158 | 0.9940 | 0.9839 | 0.7417 | |
| HCC1428 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 2.67 | uM | 11936.158 | 0.8930 | 0.7170 | 0.7417 | |
| HCC1428 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 13.3 | uM | 11936.158 | 0.6779 | 0.1841 | 0.7417 | |
| HCC1428 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 66.7 | uM | 11936.158 | 0.6825 | 0.1949 | 0.7417 | |
| HCC1569 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 10872.153 | 0.9602 | 0.9485 | 1.5576 | |
| HCC1569 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.000427 | uM | 10872.153 | 1.0147 | 1.0189 | 1.5576 | |
| HCC1569 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.00213 | uM | 10872.153 | 1.0326 | 1.0416 | 1.5576 | |
| HCC1569 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.0107 | uM | 10872.153 | 1.0775 | 1.0982 | 1.5576 | |
| HCC1569 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.0533 | uM | 10872.153 | 0.9750 | 0.9678 | 1.5576 | |
| HCC1569 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.267 | uM | 10872.153 | 0.9962 | 0.9951 | 1.5576 | |
| HCC1569 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 1.33 | uM | 10872.153 | 0.9280 | 0.9063 | 1.5576 | |
| HCC1569 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 6.67 | uM | 10872.153 | 1.0351 | 1.0447 | 1.5576 |