Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1395 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 0.0107 | uM | 12000.165 | 1.0083 | 1.0239 | 0.6978 | |
| HCC1395 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 0.0533 | uM | 12000.165 | 1.0224 | 1.0644 | 0.6978 | |
| HCC1395 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 0.267 | uM | 12000.165 | 1.0189 | 1.0544 | 0.6978 | |
| HCC1395 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 1.33 | uM | 12000.165 | 0.9951 | 0.9859 | 0.6978 | |
| HCC1395 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 6.67 | uM | 12000.165 | 0.9446 | 0.8432 | 0.6978 | |
| HCC1395 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 33.3 | uM | 12000.165 | 0.8326 | 0.5381 | 0.6978 | |
| HCC1395 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 0.000171 | uM | 12084.158 | 1.0289 | 1.0443 | 1.2976 | |
| HCC1395 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 0.000853 | uM | 12084.158 | 1.0652 | 1.0998 | 1.2976 | |
| HCC1395 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 0.00427 | uM | 12084.158 | 0.9400 | 0.9069 | 1.2976 | |
| HCC1395 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 0.0213 | uM | 12084.158 | 1.0444 | 1.0681 | 1.2976 | |
| HCC1395 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 0.107 | uM | 12084.158 | 0.9879 | 0.9813 | 1.2976 | |
| HCC1395 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 0.533 | uM | 12084.158 | 0.9169 | 0.8707 | 1.2976 | |
| HCC1395 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 2.67 | uM | 12084.158 | 0.9637 | 0.9437 | 1.2976 | |
| HCC1395 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 13.3 | uM | 12084.158 | 0.8788 | 0.8105 | 1.2976 | |
| HCC1395 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 66.7 | uM | 12084.158 | 0.6803 | 0.4863 | 1.2976 | |
| HCC1419 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 12001.165 | 0.9668 | 0.8786 | 0.5382 | |
| HCC1419 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.000427 | uM | 12001.165 | 0.9625 | 0.8630 | 0.5382 | |
| HCC1419 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.00213 | uM | 12001.165 | 0.9618 | 0.8604 | 0.5382 | |
| HCC1419 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.0107 | uM | 12001.165 | 0.9837 | 0.9397 | 0.5382 | |
| HCC1419 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.0533 | uM | 12001.165 | 0.9662 | 0.8761 | 0.5382 | |
| HCC1419 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 0.267 | uM | 12001.165 | 1.0267 | 1.1002 | 0.5382 | |
| HCC1419 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 1.33 | uM | 12001.165 | 0.9406 | 0.7848 | 0.5382 | |
| HCC1419 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 6.67 | uM | 12001.165 | 0.9138 | 0.6915 | 0.5382 | |
| HCC1419 | HER2amp | Luminal | AS-252424 | PI3K | PI3K | 33.3 | uM | 12001.165 | 0.8211 | 0.3866 | 0.5382 | |
| HCC1428 | HR+ | Luminal | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 10693.153 | 1.0057 | 1.0141 | 0.8137 |