Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1143 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.533 | uM | 12112.158 | 0.9580 | 0.9540 | 1.8430 | |
| HCC1143 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 2.67 | uM | 12112.158 | 0.8198 | 0.7956 | 1.8430 | |
| HCC1143 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 13.3 | uM | 12112.158 | 0.9229 | 0.9148 | 1.8430 | |
| HCC1143 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 66.7 | uM | 12112.158 | 0.8876 | 0.8747 | 1.8430 | |
| HCC1187 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.000171 | uM | 10518.141 | 1.0575 | 1.0870 | 1.3122 | |
| HCC1187 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.000853 | uM | 10518.141 | 1.0122 | 1.0186 | 1.3122 | |
| HCC1187 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.00427 | uM | 10518.141 | 0.9836 | 0.9750 | 1.3122 | |
| HCC1187 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.0213 | uM | 10518.141 | 1.0378 | 1.0573 | 1.3122 | |
| HCC1187 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.107 | uM | 10518.141 | 0.9560 | 0.9326 | 1.3122 | |
| HCC1187 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.533 | uM | 10518.141 | 0.6974 | 0.5197 | 1.3122 | |
| HCC1187 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 2.67 | uM | 10518.141 | 0.7461 | 0.5998 | 1.3122 | |
| HCC1187 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 13.3 | uM | 10518.141 | 0.4905 | 0.1622 | 1.3122 | |
| HCC1187 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 66.7 | uM | 10518.141 | 0.5028 | 0.1843 | 1.3122 | |
| HCC1187 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 10753.153 | 1.0063 | 1.0091 | 1.3879 | |
| HCC1187 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.000427 | uM | 10753.153 | 0.9545 | 0.9340 | 1.3879 | |
| HCC1187 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.00213 | uM | 10753.153 | 1.0187 | 1.0269 | 1.3879 | |
| HCC1187 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.0107 | uM | 10753.153 | 1.0655 | 1.0935 | 1.3879 | |
| HCC1187 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.0533 | uM | 10753.153 | 0.9859 | 0.9796 | 1.3879 | |
| HCC1187 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.267 | uM | 10753.153 | 0.7635 | 0.6466 | 1.3879 | |
| HCC1187 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 1.33 | uM | 10753.153 | 0.7398 | 0.6097 | 1.3879 | |
| HCC1187 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 6.67 | uM | 10753.153 | 0.5475 | 0.2958 | 1.3879 | |
| HCC1187 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 33.3 | uM | 10753.153 | 0.4274 | 0.0840 | 1.3879 | |
| HCC1395 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 12000.165 | 0.9864 | 0.9612 | 0.6978 | |
| HCC1395 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 0.000427 | uM | 12000.165 | 0.9588 | 0.8830 | 0.6978 | |
| HCC1395 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 0.00213 | uM | 12000.165 | 1.0725 | 1.2111 | 0.6978 |