Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1569 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 33.3 | uM | 10872.153 | 0.8671 | 0.8250 | 1.5576 | |
| HCC1569 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 12523.165 | 0.9732 | 0.9476 | 1.0249 | |
| HCC1569 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.000427 | uM | 12523.165 | 0.9901 | 0.9806 | 1.0249 | |
| HCC1569 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.00213 | uM | 12523.165 | 1.0099 | 1.0194 | 1.0249 | |
| HCC1569 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.0107 | uM | 12523.165 | 0.9943 | 0.9888 | 1.0249 | |
| HCC1569 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.0533 | uM | 12523.165 | 0.9509 | 0.9041 | 1.0249 | |
| HCC1569 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.267 | uM | 12523.165 | 0.9635 | 0.9288 | 1.0249 | |
| HCC1569 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 1.33 | uM | 12523.165 | 0.9527 | 0.9076 | 1.0249 | |
| HCC1569 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 6.67 | uM | 12523.165 | 0.9325 | 0.8682 | 1.0249 | |
| HCC1569 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 33.3 | uM | 12523.165 | 0.6726 | 0.3581 | 1.0249 | |
| HCC1806 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 12239.165 | 0.9710 | 0.9718 | 2.0705 | |
| HCC1806 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.000427 | uM | 12239.165 | 1.0188 | 1.0181 | 2.0705 | |
| HCC1806 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.00213 | uM | 12239.165 | 0.9833 | 0.9838 | 2.0705 | |
| HCC1806 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.0107 | uM | 12239.165 | 1.0016 | 1.0015 | 2.0705 | |
| HCC1806 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.0533 | uM | 12239.165 | 0.9819 | 0.9824 | 2.0705 | |
| HCC1806 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.267 | uM | 12239.165 | 0.9678 | 0.9686 | 2.0705 | |
| HCC1806 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 1.33 | uM | 12239.165 | 0.9137 | 0.9147 | 2.0705 | |
| HCC1806 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 6.67 | uM | 12239.165 | 0.5608 | 0.5125 | 2.0705 | |
| HCC1806 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 33.3 | uM | 12239.165 | 0.3055 | 0.1280 | 2.0705 | |
| HCC1937 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.000171 | uM | 11849.158 | 0.9367 | 0.9090 | 1.4054 | |
| HCC1937 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.000853 | uM | 11849.158 | 0.9885 | 0.9835 | 1.4054 | |
| HCC1937 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.00427 | uM | 11849.158 | 0.9910 | 0.9871 | 1.4054 | |
| HCC1937 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.0213 | uM | 11849.158 | 1.0077 | 1.0109 | 1.4054 | |
| HCC1937 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.107 | uM | 11849.158 | 0.9330 | 0.9037 | 1.4054 | |
| HCC1937 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.533 | uM | 11849.158 | 0.9688 | 0.9553 | 1.4054 |