Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1937 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 2.67 | uM | 11849.158 | 0.8069 | 0.7169 | 1.4054 | |
| HCC1937 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 13.3 | uM | 11849.158 | 0.8429 | 0.7709 | 1.4054 | |
| HCC1937 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 66.7 | uM | 11849.158 | 0.9367 | 0.9090 | 1.4054 | |
| HCC1954 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.000171 | uM | 11055.158 | 0.9502 | 0.9406 | 1.6948 | |
| HCC1954 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.000853 | uM | 11055.158 | 1.0257 | 1.0302 | 1.6948 | |
| HCC1954 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.00427 | uM | 11055.158 | 1.0123 | 1.0144 | 1.6948 | |
| HCC1954 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.0213 | uM | 11055.158 | 1.0701 | 1.0816 | 1.6948 | |
| HCC1954 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.107 | uM | 11055.158 | 0.9676 | 0.9615 | 1.6948 | |
| HCC1954 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 0.533 | uM | 11055.158 | 0.9203 | 0.9043 | 1.6948 | |
| HCC1954 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 2.67 | uM | 11055.158 | 0.7057 | 0.6281 | 1.6948 | |
| HCC1954 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 13.3 | uM | 11055.158 | 0.5028 | 0.3331 | 1.6948 | |
| HCC1954 | HER2amp | Basal A | AS-252424 | PI3K | PI3K | 66.7 | uM | 11055.158 | 0.5558 | 0.4142 | 1.6948 | |
| HCC2185 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 10996.153 | 0.9870 | 0.9194 | 0.3186 | |
| HCC2185 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 0.000427 | uM | 10996.153 | 1.0006 | 1.0035 | 0.3186 | |
| HCC2185 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 0.00213 | uM | 10996.153 | 1.0132 | 1.0837 | 0.3186 | |
| HCC2185 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 0.0107 | uM | 10996.153 | 0.9906 | 0.9418 | 0.3186 | |
| HCC2185 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 0.0533 | uM | 10996.153 | 0.9707 | 0.8215 | 0.3186 | |
| HCC2185 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 0.267 | uM | 10996.153 | 0.9928 | 0.9550 | 0.3186 | |
| HCC2185 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 1.33 | uM | 10996.153 | 0.9358 | 0.6240 | 0.3186 | |
| HCC2185 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 6.67 | uM | 10996.153 | 0.7773 | -0.0931 | 0.3186 | |
| HCC2185 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 33.3 | uM | 10996.153 | 0.6547 | -0.4709 | 0.3186 | |
| HCC2185 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 0.000171 | uM | 12192.158 | 0.9740 | 0.9226 | 0.6680 | |
| HCC2185 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 0.000853 | uM | 12192.158 | 0.9769 | 0.9312 | 0.6680 | |
| HCC2185 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 0.00427 | uM | 12192.158 | 1.0824 | 1.2518 | 0.6680 | |
| HCC2185 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 0.0213 | uM | 12192.158 | 1.1554 | 1.4828 | 0.6680 |