Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 0.107 | uM | 12192.158 | 1.0559 | 1.1695 | 0.6680 | |
| HCC2185 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 0.533 | uM | 12192.158 | 1.0246 | 1.0741 | 0.6680 | |
| HCC2185 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 2.67 | uM | 12192.158 | 0.9228 | 0.7733 | 0.6680 | |
| HCC2185 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 13.3 | uM | 12192.158 | 0.9113 | 0.7404 | 0.6680 | |
| HCC2185 | TNBC | Luminal | AS-252424 | PI3K | PI3K | 66.7 | uM | 12192.158 | 0.9638 | 0.8927 | 0.6680 | |
| HCC3153 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.000171 | uM | 10577.141 | 1.0060 | 1.0132 | 0.9203 | |
| HCC3153 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.000853 | uM | 10577.141 | 0.8704 | 0.7200 | 0.9203 | |
| HCC3153 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.00427 | uM | 10577.141 | 0.9743 | 0.9443 | 0.9203 | |
| HCC3153 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.0213 | uM | 10577.141 | 0.9450 | 0.8809 | 0.9203 | |
| HCC3153 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.107 | uM | 10577.141 | 1.0154 | 1.0334 | 0.9203 | |
| HCC3153 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.533 | uM | 10577.141 | 0.9511 | 0.8939 | 0.9203 | |
| HCC3153 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 2.67 | uM | 10577.141 | 0.9282 | 0.8444 | 0.9203 | |
| HCC3153 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 13.3 | uM | 10577.141 | 0.8384 | 0.6513 | 0.9203 | |
| HCC3153 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 66.7 | uM | 10577.141 | 0.8867 | 0.7551 | 0.9203 | |
| HCC3153 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 10937.153 | 0.9765 | 0.9689 | 1.5187 | |
| HCC3153 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.000427 | uM | 10937.153 | 1.0129 | 1.0170 | 1.5187 | |
| HCC3153 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.00213 | uM | 10937.153 | 0.9453 | 0.9272 | 1.5187 | |
| HCC3153 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.0107 | uM | 10937.153 | 0.9946 | 0.9928 | 1.5187 | |
| HCC3153 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.0533 | uM | 10937.153 | 0.9764 | 0.9688 | 1.5187 | |
| HCC3153 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 0.267 | uM | 10937.153 | 1.0491 | 1.0641 | 1.5187 | |
| HCC3153 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 1.33 | uM | 10937.153 | 0.9331 | 0.9109 | 1.5187 | |
| HCC3153 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 6.67 | uM | 10937.153 | 0.7965 | 0.7217 | 1.5187 | |
| HCC3153 | TNBC | Basal A | AS-252424 | PI3K | PI3K | 33.3 | uM | 10937.153 | 0.8235 | 0.7600 | 1.5187 | |
| HCC38 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 0.000171 | uM | 10578.141 | 1.0133 | 1.0170 | 1.5679 | |
| HCC38 | TNBC | Basal B | AS-252424 | PI3K | PI3K | 0.000853 | uM | 10578.141 | 0.8657 | 0.8243 | 1.5679 |