Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ZR-75-1 | HR+ | Luminal | AG1478 | EGFR | ErbB | 167 | uM | 7932.016 | 0.8526 | 0.5616 | 0.6446 | |
| ZR75B | HR+ | Luminal | AG1478 | EGFR | ErbB | 0.000427 | uM | 9972.019 | 1.0685 | 1.1283 | 1.0654 | |
| ZR75B | HR+ | Luminal | AG1478 | EGFR | ErbB | 0.00213 | uM | 9972.019 | 1.0458 | 1.0858 | 1.0654 | |
| ZR75B | HR+ | Luminal | AG1478 | EGFR | ErbB | 0.0107 | uM | 9972.019 | 1.0546 | 1.1024 | 1.0654 | |
| ZR75B | HR+ | Luminal | AG1478 | EGFR | ErbB | 0.0533 | uM | 9972.019 | 0.9560 | 0.9173 | 1.0654 | |
| ZR75B | HR+ | Luminal | AG1478 | EGFR | ErbB | 0.267 | uM | 9972.019 | 0.9842 | 0.9704 | 1.0654 | |
| ZR75B | HR+ | Luminal | AG1478 | EGFR | ErbB | 1.33 | uM | 9972.019 | 0.9143 | 0.8387 | 1.0654 | |
| ZR75B | HR+ | Luminal | AG1478 | EGFR | ErbB | 6.67 | uM | 9972.019 | 0.9222 | 0.8536 | 1.0654 | |
| ZR75B | HR+ | Luminal | AG1478 | EGFR | ErbB | 33.3 | uM | 9972.019 | 0.9593 | 0.9235 | 1.0654 | |
| ZR75B | HR+ | Luminal | AG1478 | EGFR | ErbB | 167 | uM | 9972.019 | 0.8810 | 0.7757 | 1.0654 | |
| 184A1 | NM | Basal | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 12509.165 | 1.0144 | 1.0191 | 1.5022 | |
| 184A1 | NM | Basal | AS-252424 | PI3K | PI3K | 0.000427 | uM | 12509.165 | 1.0151 | 1.0201 | 1.5022 | |
| 184A1 | NM | Basal | AS-252424 | PI3K | PI3K | 0.00213 | uM | 12509.165 | 1.0009 | 1.0012 | 1.5022 | |
| 184A1 | NM | Basal | AS-252424 | PI3K | PI3K | 0.0107 | uM | 12509.165 | 0.9308 | 0.9067 | 1.5022 | |
| 184A1 | NM | Basal | AS-252424 | PI3K | PI3K | 0.0533 | uM | 12509.165 | 1.0019 | 1.0025 | 1.5022 | |
| 184A1 | NM | Basal | AS-252424 | PI3K | PI3K | 0.267 | uM | 12509.165 | 0.8921 | 0.8536 | 1.5022 | |
| 184A1 | NM | Basal | AS-252424 | PI3K | PI3K | 1.33 | uM | 12509.165 | 0.8659 | 0.8172 | 1.5022 | |
| 184A1 | NM | Basal | AS-252424 | PI3K | PI3K | 6.67 | uM | 12509.165 | 0.5506 | 0.3443 | 1.5022 | |
| 184A1 | NM | Basal | AS-252424 | PI3K | PI3K | 33.3 | uM | 12509.165 | 0.3063 | -0.0901 | 1.5022 | |
| 184B5 | NM | Basal | AS-252424 | PI3K | PI3K | 0.0000853 | uM | 12566.165 | 0.9718 | 0.9671 | 1.7248 | |
| 184B5 | NM | Basal | AS-252424 | PI3K | PI3K | 0.000427 | uM | 12566.165 | 0.9833 | 0.9806 | 1.7248 | |
| 184B5 | NM | Basal | AS-252424 | PI3K | PI3K | 0.00213 | uM | 12566.165 | 0.9691 | 0.9639 | 1.7248 | |
| 184B5 | NM | Basal | AS-252424 | PI3K | PI3K | 0.0107 | uM | 12566.165 | 1.0915 | 1.1041 | 1.7248 | |
| 184B5 | NM | Basal | AS-252424 | PI3K | PI3K | 0.0533 | uM | 12566.165 | 0.8985 | 0.8796 | 1.7248 | |
| 184B5 | NM | Basal | AS-252424 | PI3K | PI3K | 0.267 | uM | 12566.165 | 0.9391 | 0.9284 | 1.7248 |