Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7447.067 | 0.9636 | 0.9531 | 1.5637 | |
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7447.067 | 0.3466 | 0.0157 | 1.5637 | |
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 167 | uM | 7447.067 | 0.1935 | -0.3005 | 1.5637 | |
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7448.067 | 0.9433 | 0.9594 | 2.8462 | |
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7448.067 | 0.9766 | 0.9834 | 2.8462 | |
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7448.067 | 1.0199 | 1.0139 | 2.8462 | |
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7448.067 | 0.9969 | 0.9978 | 2.8462 | |
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7448.067 | 0.9848 | 0.9893 | 2.8462 | |
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7448.067 | 1.0172 | 1.0120 | 2.8462 | |
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7448.067 | 0.8781 | 0.9107 | 2.8462 | |
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7448.067 | 0.5136 | 0.5825 | 2.8462 | |
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 167 | uM | 7448.067 | 0.6052 | 0.6765 | 2.8462 | |
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7449.067 | 1.0680 | 1.0677 | 1.9771 | |
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7449.067 | 1.0297 | 1.0298 | 1.9771 | |
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7449.067 | 0.9981 | 0.9981 | 1.9771 | |
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7449.067 | 0.9850 | 0.9848 | 1.9771 | |
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7449.067 | 1.0312 | 1.0313 | 1.9771 | |
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7449.067 | 1.0358 | 1.0359 | 1.9771 | |
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7449.067 | 1.0299 | 1.0301 | 1.9771 | |
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7449.067 | 0.8592 | 0.8522 | 1.9771 | |
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 167 | uM | 7449.067 | 1.0048 | 1.0048 | 1.9771 | |
| HCC1806 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7450.067 | 0.9699 | 0.9729 | 2.2419 | |
| HCC1806 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7450.067 | 1.0184 | 1.0163 | 2.2419 | |
| HCC1806 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7450.067 | 1.0556 | 1.0489 | 2.2419 | |
| HCC1806 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7450.067 | 1.0178 | 1.0158 | 2.2419 |