Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184B5 | NM | Basal | Purvalanol A | CDK1 | CDK | 167 | uM | 5896.067 | 0.4964 | 0.2353 | 1.4536 | |
| 184B5 | NM | Basal | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 5897.067 | 1.0470 | 1.0787 | 1.1908 | |
| 184B5 | NM | Basal | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 5897.067 | 1.0024 | 1.0041 | 1.1908 | |
| 184B5 | NM | Basal | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 5897.067 | 1.0111 | 1.0186 | 1.1908 | |
| 184B5 | NM | Basal | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 5897.067 | 1.0273 | 1.0457 | 1.1908 | |
| 184B5 | NM | Basal | Purvalanol A | CDK1 | CDK | 0.267 | uM | 5897.067 | 1.0131 | 1.0220 | 1.1908 | |
| 184B5 | NM | Basal | Purvalanol A | CDK1 | CDK | 1.33 | uM | 5897.067 | 1.0404 | 1.0676 | 1.1908 | |
| 184B5 | NM | Basal | Purvalanol A | CDK1 | CDK | 6.67 | uM | 5897.067 | 1.0273 | 1.0458 | 1.1908 | |
| 184B5 | NM | Basal | Purvalanol A | CDK1 | CDK | 33.3 | uM | 5897.067 | 0.2534 | -0.3686 | 1.1908 | |
| 184B5 | NM | Basal | Purvalanol A | CDK1 | CDK | 167 | uM | 5897.067 | 0.3893 | -0.0944 | 1.1908 | |
| 600MPE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 5898.067 | 0.9586 | 0.8747 | 0.6532 | |
| 600MPE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 5898.067 | 0.9860 | 0.9572 | 0.6532 | |
| 600MPE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 5898.067 | 0.9861 | 0.9576 | 0.6532 | |
| 600MPE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 5898.067 | 0.9764 | 0.9281 | 0.6532 | |
| 600MPE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.267 | uM | 5898.067 | 0.9736 | 0.9196 | 0.6532 | |
| 600MPE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 1.33 | uM | 5898.067 | 0.9524 | 0.8562 | 0.6532 | |
| 600MPE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 6.67 | uM | 5898.067 | 0.9654 | 0.8949 | 0.6532 | |
| 600MPE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 33.3 | uM | 5898.067 | 0.9717 | 0.9139 | 0.6532 | |
| 600MPE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 167 | uM | 5898.067 | 0.9616 | 0.8837 | 0.6532 | |
| 600MPE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 5899.067 | 0.9402 | 0.8792 | 0.9897 | |
| 600MPE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 5899.067 | 0.9357 | 0.8701 | 0.9897 | |
| 600MPE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 5899.067 | 0.9205 | 0.8395 | 0.9897 | |
| 600MPE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 5899.067 | 0.8971 | 0.7921 | 0.9897 | |
| 600MPE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.267 | uM | 5899.067 | 0.9628 | 0.9249 | 0.9897 | |
| 600MPE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 1.33 | uM | 5899.067 | 0.9633 | 0.9259 | 0.9897 |