Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 600MPE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 6.67 | uM | 5899.067 | 0.9181 | 0.8346 | 0.9897 | |
| 600MPE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 33.3 | uM | 5899.067 | 0.7285 | 0.4522 | 0.9897 | |
| 600MPE | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 167 | uM | 5899.067 | 0.4177 | -0.1721 | 0.9897 | |
| AU565 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 5900.067 | 1.0339 | 1.0276 | 2.4324 | |
| AU565 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 5900.067 | 1.0450 | 1.0365 | 2.4324 | |
| AU565 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 5900.067 | 1.0045 | 1.0037 | 2.4324 | |
| AU565 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 5900.067 | 1.0257 | 1.0210 | 2.4324 | |
| AU565 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 0.267 | uM | 5900.067 | 1.0665 | 1.0537 | 2.4324 | |
| AU565 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 1.33 | uM | 5900.067 | 1.0043 | 1.0035 | 2.4324 | |
| AU565 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 6.67 | uM | 5900.067 | 1.0809 | 1.0650 | 2.4324 | |
| AU565 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 33.3 | uM | 5900.067 | 0.9750 | 0.9793 | 2.4324 | |
| AU565 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 167 | uM | 5900.067 | 0.9845 | 0.9872 | 2.4324 | |
| AU565 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 5901.067 | 0.9925 | 0.9920 | 1.8762 | |
| AU565 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 5901.067 | 0.9646 | 0.9620 | 1.8762 | |
| AU565 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 5901.067 | 0.9717 | 0.9696 | 1.8762 | |
| AU565 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 5901.067 | 0.9708 | 0.9686 | 1.8762 | |
| AU565 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 0.267 | uM | 5901.067 | 1.0384 | 1.0406 | 1.8762 | |
| AU565 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 1.33 | uM | 5901.067 | 1.0451 | 1.0476 | 1.8762 | |
| AU565 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 6.67 | uM | 5901.067 | 0.8633 | 0.8493 | 1.8762 | |
| AU565 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 33.3 | uM | 5901.067 | 0.5842 | 0.5017 | 1.8762 | |
| AU565 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 167 | uM | 5901.067 | 0.6831 | 0.6324 | 1.8762 | |
| BT-20 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 5902.067 | 1.0196 | 1.0334 | 1.1750 | |
| BT-20 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 5902.067 | 1.0393 | 1.0668 | 1.1750 | |
| BT-20 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 5902.067 | 0.9993 | 0.9988 | 1.1750 | |
| BT-20 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 5902.067 | 1.0080 | 1.0136 | 1.1750 |