Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC70 | TNBC | Basal A | Selumetinib | MEK | MAPK | 0.08 | uM | 10873.155 | 0.7975 | 0.6757 | 1.2787 | |
| HCC70 | TNBC | Basal A | Selumetinib | MEK | MAPK | 0.4 | uM | 10873.155 | 0.6332 | 0.3990 | 1.2787 | |
| HCC70 | TNBC | Basal A | Selumetinib | MEK | MAPK | 2 | uM | 10873.155 | 0.6480 | 0.4246 | 1.2787 | |
| HCC70 | TNBC | Basal A | Selumetinib | MEK | MAPK | 10 | uM | 10873.155 | 0.7094 | 0.5290 | 1.2787 | |
| HCC70 | TNBC | Basal A | Selumetinib | MEK | MAPK | 50 | uM | 10873.155 | 0.3791 | -0.0634 | 1.2787 | |
| HCC70 | TNBC | Basal A | Selumetinib | MEK | MAPK | 0.000128 | uM | 12400.155 | 1.0006 | 1.0009 | 1.2558 | |
| HCC70 | TNBC | Basal A | Selumetinib | MEK | MAPK | 0.00064 | uM | 12400.155 | 0.9573 | 0.9316 | 1.2558 | |
| HCC70 | TNBC | Basal A | Selumetinib | MEK | MAPK | 0.0032 | uM | 12400.155 | 0.9476 | 0.9161 | 1.2558 | |
| HCC70 | TNBC | Basal A | Selumetinib | MEK | MAPK | 0.016 | uM | 12400.155 | 0.9059 | 0.8486 | 1.2558 | |
| HCC70 | TNBC | Basal A | Selumetinib | MEK | MAPK | 0.08 | uM | 12400.155 | 0.8615 | 0.7761 | 1.2558 | |
| HCC70 | TNBC | Basal A | Selumetinib | MEK | MAPK | 0.4 | uM | 12400.155 | 0.8013 | 0.6765 | 1.2558 | |
| HCC70 | TNBC | Basal A | Selumetinib | MEK | MAPK | 2 | uM | 12400.155 | 0.7298 | 0.5563 | 1.2558 | |
| HCC70 | TNBC | Basal A | Selumetinib | MEK | MAPK | 10 | uM | 12400.155 | 0.6941 | 0.4954 | 1.2558 | |
| HCC70 | TNBC | Basal A | Selumetinib | MEK | MAPK | 50 | uM | 12400.155 | 0.6826 | 0.4757 | 1.2558 | |
| Hs 578T | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.000128 | uM | 10694.146 | 1.0555 | 1.0479 | 2.2821 | |
| Hs 578T | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.00064 | uM | 10694.146 | 1.0072 | 1.0063 | 2.2821 | |
| Hs 578T | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.0032 | uM | 10694.146 | 0.9848 | 0.9866 | 2.2821 | |
| Hs 578T | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.016 | uM | 10694.146 | 1.0143 | 1.0125 | 2.2821 | |
| Hs 578T | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.08 | uM | 10694.146 | 0.9802 | 0.9826 | 2.2821 | |
| Hs 578T | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.4 | uM | 10694.146 | 0.8690 | 0.8806 | 2.2821 | |
| Hs 578T | TNBC | Basal B | Selumetinib | MEK | MAPK | 2 | uM | 10694.146 | 0.7773 | 0.7910 | 2.2821 | |
| Hs 578T | TNBC | Basal B | Selumetinib | MEK | MAPK | 10 | uM | 10694.146 | 0.6797 | 0.6887 | 2.2821 | |
| Hs 578T | TNBC | Basal B | Selumetinib | MEK | MAPK | 50 | uM | 10694.146 | 0.4944 | 0.4689 | 2.2821 | |
| LY2 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.000128 | uM | 10816.155 | 1.0869 | 1.2097 | 0.8353 | |
| LY2 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.00064 | uM | 10816.155 | 1.1136 | 1.2750 | 0.8353 |