Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.267 | uM | 5902.067 | 1.0345 | 1.0585 | 1.1750 | |
| BT-20 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 1.33 | uM | 5902.067 | 1.0504 | 1.0855 | 1.1750 | |
| BT-20 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 6.67 | uM | 5902.067 | 1.0216 | 1.0367 | 1.1750 | |
| BT-20 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 33.3 | uM | 5902.067 | 0.3796 | -0.1230 | 1.1750 | |
| BT-20 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 167 | uM | 5902.067 | 0.2481 | -0.3894 | 1.1750 | |
| BT-20 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 5903.067 | 0.9467 | 0.9149 | 1.2584 | |
| BT-20 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 5903.067 | 1.0113 | 1.0180 | 1.2584 | |
| BT-20 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 5903.067 | 0.9740 | 0.9585 | 1.2584 | |
| BT-20 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 5903.067 | 0.9465 | 0.9145 | 1.2584 | |
| BT-20 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.267 | uM | 5903.067 | 0.9873 | 0.9798 | 1.2584 | |
| BT-20 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 1.33 | uM | 5903.067 | 0.9523 | 0.9237 | 1.2584 | |
| BT-20 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 6.67 | uM | 5903.067 | 0.9637 | 0.9421 | 1.2584 | |
| BT-20 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 33.3 | uM | 5903.067 | 0.6183 | 0.3649 | 1.2584 | |
| BT-20 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 167 | uM | 5903.067 | 0.4781 | 0.1126 | 1.2584 | |
| BT-20 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 5904.067 | 1.1459 | 1.2799 | 1.0398 | |
| BT-20 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 5904.067 | 1.0301 | 1.0578 | 1.0398 | |
| BT-20 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 5904.067 | 1.0192 | 1.0368 | 1.0398 | |
| BT-20 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 5904.067 | 0.9979 | 0.9959 | 1.0398 | |
| BT-20 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 0.267 | uM | 5904.067 | 1.0572 | 1.1099 | 1.0398 | |
| BT-20 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 1.33 | uM | 5904.067 | 1.0709 | 1.1362 | 1.0398 | |
| BT-20 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 6.67 | uM | 5904.067 | 1.0372 | 1.0715 | 1.0398 | |
| BT-20 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 33.3 | uM | 5904.067 | 0.9589 | 0.9209 | 1.0398 | |
| BT-20 | TNBC | Basal A | Purvalanol A | CDK1 | CDK | 167 | uM | 5904.067 | 0.7723 | 0.5599 | 1.0398 | |
| BT-474 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 5905.067 | 1.0529 | 1.1333 | 0.7991 | |
| BT-474 | HER2amp | Luminal | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 5905.067 | 0.9818 | 0.9546 | 0.7991 |