Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 0.08 | uM | 12220.155 | 0.8602 | 0.4670 | 0.4858 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 0.4 | uM | 12220.155 | 0.7620 | 0.1430 | 0.4858 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 2 | uM | 12220.155 | 0.5690 | -0.3736 | 0.4858 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 10 | uM | 12220.155 | 0.4863 | -0.5467 | 0.4858 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 50 | uM | 12220.155 | 0.4484 | -0.6163 | 0.4858 | |
| SK-BR-3 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 0.000128 | uM | 11851.155 | 0.9813 | 0.9760 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 0.00064 | uM | 11851.155 | 0.9312 | 0.9105 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 0.0032 | uM | 11851.155 | 0.9495 | 0.9346 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 0.016 | uM | 11851.155 | 0.9715 | 0.9633 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 0.08 | uM | 11851.155 | 0.9733 | 0.9656 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 0.4 | uM | 11851.155 | 0.9340 | 0.9143 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 2 | uM | 11851.155 | 0.9216 | 0.8980 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 10 | uM | 11851.155 | 1.0563 | 1.0715 | 1.5585 | |
| SK-BR-3 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 50 | uM | 11851.155 | 0.9507 | 0.9361 | 1.5585 | |
| SUM1315MO2 | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.000128 | uM | 10875.155 | 1.0129 | 1.0347 | 0.7421 | |
| SUM1315MO2 | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.00064 | uM | 10875.155 | 1.0883 | 1.2415 | 0.7421 | |
| SUM1315MO2 | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.0032 | uM | 10875.155 | 1.0093 | 1.0251 | 0.7421 | |
| SUM1315MO2 | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.016 | uM | 10875.155 | 1.0804 | 1.2198 | 0.7421 | |
| SUM1315MO2 | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.08 | uM | 10875.155 | 0.9563 | 0.8830 | 0.7421 | |
| SUM1315MO2 | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.4 | uM | 10875.155 | 0.9284 | 0.8094 | 0.7421 | |
| SUM1315MO2 | TNBC | Basal B | Selumetinib | MEK | MAPK | 2 | uM | 10875.155 | 0.8584 | 0.6280 | 0.7421 | |
| SUM1315MO2 | TNBC | Basal B | Selumetinib | MEK | MAPK | 10 | uM | 10875.155 | 0.8445 | 0.5927 | 0.7421 | |
| SUM1315MO2 | TNBC | Basal B | Selumetinib | MEK | MAPK | 50 | uM | 10875.155 | 0.6689 | 0.1633 | 0.7421 | |
| SUM1315MO2 | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.000128 | uM | 12428.155 | 1.0091 | 1.0239 | 0.7654 | |
| SUM1315MO2 | TNBC | Basal B | Selumetinib | MEK | MAPK | 0.00064 | uM | 12428.155 | 0.9532 | 0.8785 | 0.7654 |