Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 167 | uM | 7442.067 | 0.7522 | 0.4640 | 0.9126 | |
| HCC1428 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7443.067 | 0.9651 | 0.9324 | 1.0344 | |
| HCC1428 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7443.067 | 0.9862 | 0.9733 | 1.0344 | |
| HCC1428 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7443.067 | 0.9855 | 0.9719 | 1.0344 | |
| HCC1428 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7443.067 | 1.0057 | 1.0109 | 1.0344 | |
| HCC1428 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7443.067 | 0.9710 | 0.9439 | 1.0344 | |
| HCC1428 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7443.067 | 0.9738 | 0.9494 | 1.0344 | |
| HCC1428 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7443.067 | 0.9843 | 0.9697 | 1.0344 | |
| HCC1428 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7443.067 | 0.8178 | 0.6466 | 1.0344 | |
| HCC1428 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 167 | uM | 7443.067 | 0.5794 | 0.1800 | 1.0344 | |
| HCC1428 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7444.067 | 1.0784 | 1.2153 | 0.7382 | |
| HCC1428 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7444.067 | 1.0218 | 1.0594 | 0.7382 | |
| HCC1428 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7444.067 | 1.0327 | 1.0891 | 0.7382 | |
| HCC1428 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7444.067 | 1.0252 | 1.0685 | 0.7382 | |
| HCC1428 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7444.067 | 1.0532 | 1.1455 | 0.7382 | |
| HCC1428 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7444.067 | 1.0380 | 1.1037 | 0.7382 | |
| HCC1428 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 6.67 | uM | 7444.067 | 1.0285 | 1.0776 | 0.7382 | |
| HCC1428 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 33.3 | uM | 7444.067 | 1.0104 | 1.0282 | 0.7382 | |
| HCC1428 | HR+ | Luminal | Purvalanol A | CDK1 | CDK | 167 | uM | 7444.067 | 0.9402 | 0.8396 | 0.7382 | |
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 0.000427 | uM | 7447.067 | 1.0260 | 1.0331 | 1.5637 | |
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 0.00213 | uM | 7447.067 | 1.0274 | 1.0349 | 1.5637 | |
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 0.0107 | uM | 7447.067 | 0.9933 | 0.9915 | 1.5637 | |
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 0.0533 | uM | 7447.067 | 0.9995 | 0.9994 | 1.5637 | |
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 0.267 | uM | 7447.067 | 0.9639 | 0.9535 | 1.5637 | |
| HCC1569 | HER2amp | Basal A | Purvalanol A | CDK1 | CDK | 1.33 | uM | 7447.067 | 0.9570 | 0.9445 | 1.5637 |