Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | TNBC | Luminal | Selumetinib | MEK | MAPK | 2 | uM | 12414.155 | 0.9968 | 0.9948 | 1.2420 | |
| MDA-MB-453 | TNBC | Luminal | Selumetinib | MEK | MAPK | 10 | uM | 12414.155 | 0.8382 | 0.7350 | 1.2420 | |
| MDA-MB-453 | TNBC | Luminal | Selumetinib | MEK | MAPK | 50 | uM | 12414.155 | 0.8428 | 0.7427 | 1.2420 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 0.000128 | uM | 10644.146 | 1.0610 | 1.2087 | 0.5967 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 0.00064 | uM | 10644.146 | 0.9562 | 0.8552 | 0.5967 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 0.0032 | uM | 10644.146 | 1.0001 | 1.0005 | 0.5967 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 0.016 | uM | 10644.146 | 0.9341 | 0.7840 | 0.5967 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 0.08 | uM | 10644.146 | 0.9456 | 0.8211 | 0.5967 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 0.4 | uM | 10644.146 | 0.9133 | 0.7179 | 0.5967 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 2 | uM | 10644.146 | 0.6404 | -0.0524 | 0.5967 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 10 | uM | 10644.146 | 0.3374 | -0.6762 | 0.5967 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 50 | uM | 10644.146 | 0.1440 | -0.9223 | 0.5967 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 0.000128 | uM | 10874.155 | 1.0263 | 1.0651 | 0.8099 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 0.00064 | uM | 10874.155 | 1.0056 | 1.0139 | 0.8099 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 0.0032 | uM | 10874.155 | 1.0131 | 1.0324 | 0.8099 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 0.016 | uM | 10874.155 | 1.0491 | 1.1219 | 0.8099 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 0.08 | uM | 10874.155 | 0.8733 | 0.6919 | 0.8099 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 0.4 | uM | 10874.155 | 0.8135 | 0.5501 | 0.8099 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 2 | uM | 10874.155 | 0.5768 | 0.0139 | 0.8099 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 10 | uM | 10874.155 | 0.5313 | -0.0839 | 0.8099 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 50 | uM | 10874.155 | 0.3671 | -0.4198 | 0.8099 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 0.000128 | uM | 12220.155 | 0.9765 | 0.9044 | 0.4858 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 0.00064 | uM | 12220.155 | 0.9440 | 0.7763 | 0.4858 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 0.0032 | uM | 12220.155 | 0.9043 | 0.6260 | 0.4858 | |
| MX1 | Unknown | Unknown | Selumetinib | MEK | MAPK | 0.016 | uM | 12220.155 | 0.9038 | 0.6242 | 0.4858 |