Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | Selumetinib | MEK | MAPK | 50 | uM | 12379.155 | 0.9777 | 0.8847 | 0.3793 | |
| MDA-MB-415 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.000128 | uM | 10938.155 | 1.2682 | 2.1217 | 0.5336 | |
| MDA-MB-415 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.00064 | uM | 10938.155 | 1.1574 | 1.6303 | 0.5336 | |
| MDA-MB-415 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.0032 | uM | 10938.155 | 1.3573 | 2.5456 | 0.5336 | |
| MDA-MB-415 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.016 | uM | 10938.155 | 1.3151 | 2.3415 | 0.5336 | |
| MDA-MB-415 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.08 | uM | 10938.155 | 1.3194 | 2.3620 | 0.5336 | |
| MDA-MB-415 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.4 | uM | 10938.155 | 1.3757 | 2.6359 | 0.5336 | |
| MDA-MB-415 | HR+ | Luminal | Selumetinib | MEK | MAPK | 2 | uM | 10938.155 | 1.2158 | 1.8842 | 0.5336 | |
| MDA-MB-415 | HR+ | Luminal | Selumetinib | MEK | MAPK | 10 | uM | 10938.155 | 1.2506 | 2.0410 | 0.5336 | |
| MDA-MB-415 | HR+ | Luminal | Selumetinib | MEK | MAPK | 50 | uM | 10938.155 | 1.1798 | 1.7266 | 0.5336 | |
| MDA-MB-415 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.000128 | uM | 12333.155 | 0.9959 | 0.9858 | 0.5790 | |
| MDA-MB-415 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.00064 | uM | 12333.155 | 0.9755 | 0.9162 | 0.5790 | |
| MDA-MB-415 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.0032 | uM | 12333.155 | 0.9863 | 0.9529 | 0.5790 | |
| MDA-MB-415 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.016 | uM | 12333.155 | 0.9864 | 0.9532 | 0.5790 | |
| MDA-MB-415 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.08 | uM | 12333.155 | 0.9630 | 0.8738 | 0.5790 | |
| MDA-MB-415 | HR+ | Luminal | Selumetinib | MEK | MAPK | 0.4 | uM | 12333.155 | 0.9064 | 0.6878 | 0.5790 | |
| MDA-MB-415 | HR+ | Luminal | Selumetinib | MEK | MAPK | 2 | uM | 12333.155 | 0.8383 | 0.4747 | 0.5790 | |
| MDA-MB-415 | HR+ | Luminal | Selumetinib | MEK | MAPK | 10 | uM | 12333.155 | 0.7387 | 0.1853 | 0.5790 | |
| MDA-MB-415 | HR+ | Luminal | Selumetinib | MEK | MAPK | 50 | uM | 12333.155 | 0.5771 | -0.2260 | 0.5790 | |
| MDA-MB-453 | TNBC | Luminal | Selumetinib | MEK | MAPK | 0.000128 | uM | 12414.155 | 1.0138 | 1.0222 | 1.2420 | |
| MDA-MB-453 | TNBC | Luminal | Selumetinib | MEK | MAPK | 0.00064 | uM | 12414.155 | 0.9559 | 0.9288 | 1.2420 | |
| MDA-MB-453 | TNBC | Luminal | Selumetinib | MEK | MAPK | 0.0032 | uM | 12414.155 | 1.0250 | 1.0402 | 1.2420 | |
| MDA-MB-453 | TNBC | Luminal | Selumetinib | MEK | MAPK | 0.016 | uM | 12414.155 | 0.9600 | 0.9354 | 1.2420 | |
| MDA-MB-453 | TNBC | Luminal | Selumetinib | MEK | MAPK | 0.08 | uM | 12414.155 | 1.0291 | 1.0468 | 1.2420 | |
| MDA-MB-453 | TNBC | Luminal | Selumetinib | MEK | MAPK | 0.4 | uM | 12414.155 | 1.0446 | 1.0714 | 1.2420 |