Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1937 | TNBC | Basal A | Selumetinib | MEK | MAPK | 50 | uM | 11849.155 | 0.8735 | 0.8273 | 1.4975 | |
| HCC1954 | HER2amp | Basal A | Selumetinib | MEK | MAPK | 0.000128 | uM | 11055.155 | 0.9851 | 0.9829 | 1.7439 | |
| HCC1954 | HER2amp | Basal A | Selumetinib | MEK | MAPK | 0.00064 | uM | 11055.155 | 1.0129 | 1.0147 | 1.7439 | |
| HCC1954 | HER2amp | Basal A | Selumetinib | MEK | MAPK | 0.0032 | uM | 11055.155 | 0.9875 | 0.9856 | 1.7439 | |
| HCC1954 | HER2amp | Basal A | Selumetinib | MEK | MAPK | 0.016 | uM | 11055.155 | 0.9911 | 0.9898 | 1.7439 | |
| HCC1954 | HER2amp | Basal A | Selumetinib | MEK | MAPK | 0.08 | uM | 11055.155 | 0.8014 | 0.7615 | 1.7439 | |
| HCC1954 | HER2amp | Basal A | Selumetinib | MEK | MAPK | 0.4 | uM | 11055.155 | 0.7788 | 0.7328 | 1.7439 | |
| HCC1954 | HER2amp | Basal A | Selumetinib | MEK | MAPK | 2 | uM | 11055.155 | 0.6153 | 0.5138 | 1.7439 | |
| HCC1954 | HER2amp | Basal A | Selumetinib | MEK | MAPK | 10 | uM | 11055.155 | 0.6010 | 0.4936 | 1.7439 | |
| HCC1954 | HER2amp | Basal A | Selumetinib | MEK | MAPK | 50 | uM | 11055.155 | 0.5372 | 0.4005 | 1.7439 | |
| HCC2185 | TNBC | Luminal | Selumetinib | MEK | MAPK | 0.000128 | uM | 10996.155 | 0.9948 | 0.9850 | 0.6934 | |
| HCC2185 | TNBC | Luminal | Selumetinib | MEK | MAPK | 0.00064 | uM | 10996.155 | 0.9418 | 0.8343 | 0.6934 | |
| HCC2185 | TNBC | Luminal | Selumetinib | MEK | MAPK | 0.0032 | uM | 10996.155 | 0.9568 | 0.8767 | 0.6934 | |
| HCC2185 | TNBC | Luminal | Selumetinib | MEK | MAPK | 0.016 | uM | 10996.155 | 1.0263 | 1.0763 | 0.6934 | |
| HCC2185 | TNBC | Luminal | Selumetinib | MEK | MAPK | 0.08 | uM | 10996.155 | 1.0197 | 1.0571 | 0.6934 | |
| HCC2185 | TNBC | Luminal | Selumetinib | MEK | MAPK | 0.4 | uM | 10996.155 | 0.8804 | 0.6644 | 0.6934 | |
| HCC2185 | TNBC | Luminal | Selumetinib | MEK | MAPK | 2 | uM | 10996.155 | 0.9510 | 0.8603 | 0.6934 | |
| HCC2185 | TNBC | Luminal | Selumetinib | MEK | MAPK | 10 | uM | 10996.155 | 0.9949 | 0.9852 | 0.6934 | |
| HCC2185 | TNBC | Luminal | Selumetinib | MEK | MAPK | 50 | uM | 10996.155 | 0.9906 | 0.9728 | 0.6934 | |
| HCC2185 | TNBC | Luminal | Selumetinib | MEK | MAPK | 0.000128 | uM | 12192.155 | 0.8670 | 0.6513 | 0.7451 | |
| HCC2185 | TNBC | Luminal | Selumetinib | MEK | MAPK | 0.00064 | uM | 12192.155 | 0.9715 | 0.9238 | 0.7451 | |
| HCC2185 | TNBC | Luminal | Selumetinib | MEK | MAPK | 0.0032 | uM | 12192.155 | 1.0212 | 1.0570 | 0.7451 | |
| HCC2185 | TNBC | Luminal | Selumetinib | MEK | MAPK | 0.016 | uM | 12192.155 | 1.0588 | 1.1595 | 0.7451 | |
| HCC2185 | TNBC | Luminal | Selumetinib | MEK | MAPK | 0.08 | uM | 12192.155 | 0.9063 | 0.7526 | 0.7451 | |
| HCC2185 | TNBC | Luminal | Selumetinib | MEK | MAPK | 0.4 | uM | 12192.155 | 0.9503 | 0.8679 | 0.7451 |